Pilot Projects Program

Round 2 Pilot Project Awardees

Jessica Heath, MD
Jessica Heath, MD

"Targeting Leukemia: A Sticky Situation"

Targeting Cell Adhesion in CALM-AF10 Leukemias

How sticky is a cell, and how does that influence how a cancer cell might spread? Dr. Jessica Heath was awarded a pilot project to investigate cell adhesion in CALM-AF10 leukemias, a specific type of leukemia seen in children and adolescents. Cell adhesion is how cells stick to each other or things in their environment, such as blood vessels. This process has the potential to change the properties of the cell itself, including how they survive or how they can move around the body. Dr. Heath and her team noticed that cancer cells containing the CALM-AF10 fusion protein seemed to be a little stickier than others, so they wanted to see if that changes how they interact with the tumor microenvironment. Indeed, CALM-AF10 leukemia cells were moving more than others, and they were able to decrease that migration by inhibiting a specific protein, CXCR4. However, inhibiting CXCR4 during chemotherapy was not enough to increase the effectiveness of treatment, and Dr. Heath says this was a critical discovery because it highlighted the importance of carefully selecting the right targets for treatment and drug development. This project led to publication and helped advance the research careers of trainees.

“For cancer cells, what we’ve been finding is that those changes [from cell adhesion] can sometimes influence how cancer cells move, how they metastasize, how they get access to blood vessels to move around the body, and it can even change how they divide, how they grow, and how they respond to chemotherapy. So that process of cell adhesion can be really important for understanding how to better treat cancer."

 

  1. Fertal SA, Zaidi SK, Stein JL, Stein GS, Heath JL. CXCR4 Mediates Enhanced Cell Migration in CALM-AF10 Leukemia. Front Oncol. 2022 Jan 5;11:708915. doi: 10.3389/fonc.2021.708915. PMID: 35070954; PMCID: PMC8767107.
  2. Heath JL, Cohn GM, Zaidi SK, Stein GS. The role of cell adhesion in hematopoiesis and leukemogenesis. J Cell Physiol. 2019 Nov;234(11):19189-19198. doi: 10.1002/jcp.28636. Epub 2019 Apr 13. PMID: 30980400.
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An Atlas of Rural and Urban Variation in Cardiac Arrest Processes of Care and Outcomes in Northern New England: Toward Improved Outcomes After Rural Cardiac Arrest

As a tertiary care center, MaineHealth receives transfers of cardiac arrest patients from all over the state. Dr. Teresa May’s project focused on answering a seemingly simple question: How are they doing at treating these patients? Finding that answer, however, requires analyzing and understanding a wide variety of data. Using Emergency Medical Services registry data and vital health records from the government, they began to explore the different factors influencing health outcomes for these patients. They noted disparities between rural and urban patients, but Dr. May says there are a lot of details that need to be considered. The patients themselves are different, the response times to emergency calls are different, and the types of treatment provided are often different. The project team is digging through a vast treasure of data to isolate the key factors impacting health outcomes across rural and urban areas with the hopes of one day standardizing care in Intensive Care Units across the region so no matter where a patient is, they will get the same and the best care. Since being awarded, Dr. May and her team have already begun to identify useful metrics that may help lead them to better care practices. The pilot has grown into a larger project under the Acute Care COBRE at MaineHealth and is being developed into an R01 application that will include many of the rural states not just across the region, but across the country.

“The thing I learned is there’s still a lot to learn. And what was really surprising was the amount of cardiac arrests that were happening across the state. I only see the patients who arrive in my ED or my ICU, but the number of patients that don’t make it to this hospital is high. And we knew that based on national data, but it’s different when you’re looking at your state and your community."

Teresa May, DO

Teresa May, DO

"The Pirate's Heart: Digging for Data"

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Kinna Thakarar, DO

Kinna Thakarar, DO

"Injections & Infections: Using Research to Advocate for Change"

Rural Harm Reduction Access and Regional Trends

Over the past ten years, northern New England has seen a surge of infections related to injection drug use that occur as a result of unsafe injection practices. In addition to programs aimed at reducing opioid and injection drug use, many programs have been launched to mitigate the hazards of injection and provide safer options. In other words, their goal is harm reduction, and it is this programming that Dr. Kinna Thakarar of MaineHealth received her pilot award to study. One of the most common harm reduction programs are syringe services, which provide clean syringes for people who use drugs so they do not have to risk infection, but according to Dr. Thakarar, many still aren’t able to access these programs. Her pilot work found that the biggest barrier to accessing syringe service programs is distance. People living more than 10 miles from such a center are significantly less likely to use the service, but in such a rural state as Maine, that is the reality for a lot of people. Once the main barriers to harm reduction services were identified, Dr. Thakarar continued to use those lessons learned to enact programmatic change. Her philosophy is to use research as an advocacy tool, leveraging results to advocate for change that will help others. To achieve that goal, Dr. Thakarar and her team shared the results of this pilot to provide testimony for legislative bills, updates at the Governor’s Opioid Summit and the Governor’s Seminar Series, and to educate colleagues in what we as a region need to do to ensure harm reduction programs are accessible to all, especially rural communities.

“[The Pilot Project Program] gave me the experience and data to apply for additional funding. Based on the work we did for the program, I also connected with other people in the field and am forming some exciting collaborations, and so it’s also opened a lot of doors in terms of connections."

 

  1. Thakarar K, Sankar N, Murray K, Lucas FL, Burris D, Smith RP. Injections and infections: understanding syringe service program utilization in a rural state. Harm Reduct J. 2021 Jul 17;18(1):74. doi: 10.1186/s12954-021-00524-1. PMID: 34273986; PMCID: PMC8285696.
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Feasibility and Preliminary Effectiveness of a Community Health Worker-Delivered Intervention to Slow Progression of Functional Decline among At-Risk Rural Older Adults

Michael LaMantia, MD, MPH (University of Vermont)

 

Direct and Indirect Mechanisms of Opioid-Induced Bone Loss

Katherine Motyl, PhD (MaineHealth)

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