Vision
A premier research center on brain blood vessels, the Totman Medical Research Trust supports an interdepartmental, highly interactive research group focused on key aspects of brain artery function from molecules to clinical applications.
Participants
Trustees
Ms. Arlene Howard - Malone, NY
Mr. Donald Stone Jr. - Vienna, VA
Mr. Jeffrey Stone - Waterford, NY
Advisory Board
W. Jonathan Lederer, M.D., Ph.D. Professor and Director, Medical Biotechnology Center, University of Maryland; Visiting Professor, Department of Pharmacology, University of Vermont
Institutional Leadership
Richard L. Page, M.D.
Dean, College of Medicine
Gordon Jensen, M.D., Ph.D. Senior Associate Dean for Research
Brian Cote
Associate Dean for Finance and Administration, College of Medicine
Faculty
Mark T. Nelson, Ph.D., Professor and Chair, Department of Pharmacology; Professor, Department of Molecular Physiology & Biophysics
George C. Wellman, Ph.D., Professor, Departments of Pharmacology and Surgery (Division of Neurosurgery)
Marilyn J. Cipolla, Ph.D., Professor, Departments of Neurology, Obstetrics & Gynecology, and Pharmacology
Wolfgang R. Dostmann, Ph.D., Professor, Departments of Pharmacology and Molecular Physiology & Biophysics
Kalev Freeman, M.D., Ph.D., Assistant Professor, Department of Surgery, Assistant Professor, Pharmacology
Albert L. Gonzales, Ph.D., Research Assistant Professor, Department of Pharmacology
Osama Harraz, Ph.D., Research Assistant Professor, Department of Pharmacology
Grant W. Hennig, Ph.D. Research Assistant Professor, Department of Pharmacology
Thomas Heppner, Ph.D., Research Assistant Professor, Department of Pharmacology
Gerald Herrera, Ph.D., Research Assistant Professor, Department of Pharmacology
David Hill-Eubanks, Ph.D., Research Assistant Professor, Department of Pharmacology
Masayo Koide, Ph.D., Research Assistant Professor, Department of Pharmacology
Maria Sancho Gonzales, Ph.D., Research Assistant Professor, Department of Pharmacology
Research Technical Support
Joseph Charles, M.S.
Research Technician, Dostmann Laboratory
Daniel Enders
Research Technician, Nelson Laboratory
Hannah Ferris
Research Technician, Wellman Laboratory
Nicholas Grubinger
Research Technician, Freeman Laboratory
Olivia Siroonian
Research Technician, Cipolla Laboratory
Adrian Sakheim
Research Technician, Freeman Laboratory
Sarah Tremble
Senior Research Technician, Cipolla Laboratory
Theresa Wellman
Senior Research Technician, Nelson Laboratory
Post-Doctoral Trainees
Nicholas Klug, Ph.D.
Postdoctoral Fellow, Nelson Laboratory
Amreen Mughal, Ph.D.
Postdoctoral Fellow, Nelson Laboratories
Student Trainees
Connor Cronin
Graduate Student, Dostmann Lab
Nathalie Labinger
Undergraduate Student, Nelson Lab
Zhaojin Li
Graduate Student, Cipolla Lab
Elizabeth Pendlebury
Graduate Student, Dostmann Lab
Perin Patel
Undergraduate Student, Nelson Lab
2019 Totman Lecturer
Serge Charpak, M.D., Ph.D.
Research Director - INSERM (the French National Institute of Health and Medical Research)
University of Paris
7-Denis Diderot
Paris, France
Publications
Mark T. Nelson, Ph.D.
1. *Moshkforoush A, Ashenagar B, Harraz OF, Dabertrand F, Longden TA, Nelson MT, Tsoukias NM. The capillary Kir channel as sensor and amplifier of neuronal signals: modeling insights on K+-mediated neurovascular communication. Accepted for publication May 22, 2020. Proc Natl Acad Sci USA 2020 June 29: 202000151. doi: 10.1073/pnas.2000151117. PMID: 32601236
2. *Ratelade J, Klug NR, Lombardi D, Cruz Angelim MKS, Dabertrand F, Domenga-Denier V, Salam RA, et al. Reducing Hypermuscularization of the Transitional Segment between Arterioles and Capillaries Protects Against Spontaneous Intracerebral Hemorrhage. Circulation, Epub. 2020 Mar 18. doi: org/10.1161/CIRCULATIONAHA.119.040963, PMID: 32183562
3. *Zhao G, Joca HC, Nelson MT, Lederer WJ. ATP-and voltage-dependent electro metabolic signaling regulates blood flow in heart. Proc Natl Acad Sci USA. 2020 Mar 13. doi: 10.1073/pnas.1922095117. PMID: 32170008
4. *Dow N, Coleman JR, Moore H, Osborn ZT, Sackheim AM, Hennig G, Butenas S, Nelson MT, Moore EE, Freeman F. Dense and dangerous: The tissue plasminogen activator-resistant fibrinolysis shutdown phenotype is due to abnormal fibrin polymerization: J Trauma Acute Care Surg. 2020 Feb; 88(2): 258-264. doi: 10.1097/TA.0000000000002554. PMID: 31999655
5. *Csato V, Kadir SZSA, Khavandi K, Bennett H, Sugden S, Gurney AM, Pritchard HT, Hill-Eubanks D, Eaton P, Nelson MT, Greenstein AS. “A Step and a Ceiling”: mechanical properties of Ca2+ spark vasoregulation in resistance arteries by pressure-induced oxidative activation of PKG. Physiol Rep. 2019 Nov; 7(22): e14260. doi: 10.14814/phy2.14260. PMID: 31782255, PMCID: PMC6883097
George C. Wellman, Ph.D.
1. *Syed AU, Koide M, Brayden JE, Wellman GC. Tonic regulation of middle meningeal artery (MMA) diameter by ATP-sensitive potassium channels. J. Cereb Blood Flow Metab. 2019 Apr; 39(4): 670-679. doi: 10.117/0271678X17749392. PMID: 29260608, PMCID: PMC6446425
2. *Koide M, Collier DM, Ferris HR, Brayden JE, Nelson MT, Wellman GC (2019). Activation of smooth muscle TRPV1 channels in non-brain arteries contributes to cerebral blood flow maintenance during acute decreases in blood pressure. Brain & Brain PET 2019, Yokohama, Japan, July 4-7, 2019. J. Cerebral Blood Flow and Metabolism 39: 293-294 (meeting abstract).
Marilyn J. Cipolla, Ph.D.
1. *Li Z, Lindner D, Bishop N, and Cipolla MJ (2020): Angiotensin converting enzyme inhibition reverses vasoconstriction and impaired dilation of pial collaterals in chronic hypertension. Hypertension (In press).
Book Chapter
1. *Whittaker E and Cipolla MJ. Perinatal Stroke Handbook of Clinical Neurology: Neurology and Pregnancy. Elsevier. Editors: Steegers EAP, Cipolla MJ and Miller E.
Wolfgang R. Dostmann, Ph.D.
1. *Averill AM, Rehman HT, Charles JW, Dinh TA, Danyal K, Verschraegen CF, Stein GS, Dostmann WR, Ramsey JE. Inhibition of the chimeric DnaJ-PKAc enzyme by endogenous inhibitor proteins. J Cell Biochem. 2019 Aug; 120(8): 13783-13791. doi: 10.1002/jcb.28651. PMID: 30938854
Kalev Freeman, M.D.
1. *Villalba N, Osborn Z, Derickson P, Manning C, Herrington R, Kaminsky D, Freeman K. Diagnostic Performance of Pulse Cooximetry in the Emergency Department. Respiratory Care. 2019 Nov; 64(11):1351-1357. PMID: 31040204.
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Adam S. Greenstein, M.D., Ph.D.
1. *Pritchard HAT, Griffin CS, Yamasaki E, Thakore P, Lane C, Greenstein AS, Earley S. Nanoscale Coupling of Junctophilin-2 and Ryanodine Receptors Regulates Vascular Smooth Muscle Cell Contractility. PNAS (2019); 116(43): 21874-21881
2. *Greenstein AS, Kadir S, Csato V, Baylie R, Sugden S, Eisner DA, Nelson MT. Disruption of pressure - induced Ca2+ spark vasoregulation of resistance arteries, rather than endothelial dysfunction, underlies obesity - related hypertension. Hypertension (2020);75(2):539-548
*Totman Medical Research Fund Acknowledged