University of Vermont Cancer Center Research Programs

UVM Cancer Center programs are organized to facilitate translation of discoveries from innovative basic science and translational investigation to clinical trials. The ultimate goal is to introduce innovative improvements to cancer patient care. Through partnerships of researchers in our UVM Cancer Center programs with physician-investigators in our transdisciplinary teams (TDTs), our programs focus on the biological continuum of cancer control, initiation, progression, and population dynamics with emphasis on translating laboratory discovery to patient care.

To view the Program Meeting Calendar click here.

Cancer Control and Population Health Sciences (CCPHS)

Addresses timely questions that are relevant to cancer prevention, early detection and survivorship with a focus in the areas of breast cancer screening, tobacco control and survivorship; additional focus on these in the context of our rural catchment area.

Sprague, Brian & Villanti, Andrea

Program Leaders

Brian Sprague, PhD, Director of the Vermont Breast Cancer Surveillance System & Associate Professor Surgery

Maija Reblin, PhD, Associate Professor and member of the Vermont Conversation Lab.

Scientific Program Themes

  1. Ascertainment and evaluation of risk factors contributing to development of cancer; specifically, behavioral risk factors and biomarkers of risk.
  2. Evaluation and development of cancer screening strategies with emphasis on harm reduction.
  3. Investigation and improvement of health-related outcomes and quality of life for cancer survivors.
  4. Ascertainment and improvement of access to high-quality cancer care and cancer prevention for rural populations.


Host Factors and Tumor Progression (HFTP)

Encompasses chronic inflammation, obesity, diet, exercise, nutrition, coagulation, immune surveillance and modulation, vaccines, tumor cell niches, metastasis, and symptom management. This program focuses on parameters in the host that promote or impede progression or recurrence, with an emphasis on host conditions that may influence progression to clinically significant disease.

Kaufman, Peter & Lian, Jane

Program Leaders

Peter Kaufman, MD, Professor of Medicine

Jane B. Lian, PhD, Professor of Biochemistry

Scientific Program Themes

  1. Mechanisms of cancer contributed by host factors from initiation to metastasis in order to develop clinically relevant solutions.
  2. Influence of the tumor tissue microenvironment from various cell types (CSCs, stromal, hematopoietic and immune cells) on migration, angiogenesis, EMT and metastasis.
  3. Translation of findings to patient care.

Molecular Mechanisms of Malignancy (MMM)

Basic research in cancer stem cells, DNA damage and repair, genome instability, cell cycle defects, corruption of signaling pathways, redox homeostasis, changes in cell differentiation and cell metabolism, cell motility, and environmental carcinogens. Discovery in this program is directed toward identifying cellular biomarkers with prognostic value and new therapeutic targets.

MMM Program Leaders: Marc Greenblatt and Seth Freitze (left to right)

Program Leaders

Marc Greenblatt, MD, Professor of Medicine

Seth Frietze, PhD, Assistant Professor of Biomedical and Health Sciences, UVM College of Nursing and Health Sciences

Scientific Program Themes

  1. Epigenetics.
  2. Molecular mechanisms of hematological malignancies.
  3. Mechanisms of breast cancer progression and breast cancer treatment response.
  4. DNA damage and repair and its role in carcinogenesis.
  5. Redox signaling in the pathology and therapy of disease.


Monthly Program Meeting Details

CCPHS Program Meetings: First Wednesday of every month, noon - 1 p.m. 

MMM Program Meetings: Fourth Friday of every month, 3 p.m. - 4 p.m.