Key Publications

Ruggles, E. L.; Deker, P. B.; Hondal, R. J. Conformational analysis of oxidized peptide fragments of the C-terminal redox center in thioredoxin reductases by NMR spectroscopy, J. Pept. Sci. DOI: 10.1002/psc.2620.

Lothrop, A. P.; Snider, G. W.; Flemer, S. Jr.; Ruggles, E. L.; Davidson, R. S.; Lamb, A.; Hondal, R. J. Compensating for the absence of selenocysteine in high Mr thioredoxin reductases: The electrophilic activation hypothesis, Biochemistry 2014, 53, 664-674.

Lothrop, A. P.; Snider, G. W.; Ruggles, E. L.; Patel, A. S.; Lees, W. J.; Hondal, R. J. Selenium as an electron acceptor during the catalytic mechanism of thioredoxin reductase, Biochemistry 2014, 53, 654-663.

Snider, G. W.; Dustin, C. M.; Ruggles, E. L.; Hondal, R. J. A mechanistic investigation of the C-terminal redox motif of thioredoxin reductase from Plasmodium falciparum, Biochemistry 2014, 53, 601-609.

Lothrop, A. P.; Snider, G. W.; Ruggles, E. L.; Hondal, R. J. Why is mammalian thioredoxin reductase-1 so dependent upon the use of selenium, Biochemistry 2014, 53, 554-565.

Snider, G. W.; Ruggles, E. L.; Khan, N.; Hondal, R. J. Selenocysteine Confers Resistance to Inactivation by Oxidation in Thioredoxin Reductase: Comparison of Selenium and Sulfur Enzymes, Biochemistry 2013, 52, 5472-5481.

Ruggles, E. L.; Snider, G.; Hondal, R. J. Chapter Six, Chemical Basis for the Use of Selenocysteine, In Selenium: Its Molecular Biology and Role in Human Health; Hatfield, D. L., Berry, M. J., Gladyshev, V. N., Eds.; Springer: New York, 2012, 73-83.

Hondal, R., and Ruggles, E. Differing views of the role of selenium in thioredoxin reductase. Amino Acids. 2011 Jun;41(1):73-89. Epub 2010 Feb 21. PMID: 20397034

Snider, G.; Grout, L.; Ruggles, E. L.; Hondal, R. J. Methaneseleninic Acid is a Substrate for Truncated Mammalian Thioredoxin Reductase: Implications for the Catalytic Mechanism and Redox Signaling, Biochemistry 2010, 49, 10329-10338.

Lothrop, A. P.; Ruggles, E. L.; Hondal, R. J. “No Selenium Required: Reactions Catalyzed by Mammalian Thioredoxin Reductase That Are Independent of a Selenocyteine Residue.” Biochemistry 2009, 48, 6213-6223.

Ruggles, E. L.; Deker, P. B.; Hondal. R. J. “Synthesis, Redox Properteis, and Conformational Analysis of Vicinal Disulfide Ring Mimics.” Tetrahedron 2009, 65, 1257-1267

Ruggles, E. L.; Flemer Jr., S.; Hondal, R. J. “Viable Synthesis of N-Methyl Cysteine.” Biopolymers 2008, 90, 61-68.

All Publications

Dr. Erik Ruggles