Research

Dr. Tracy’s lab is involved in a number of molecular and genetic epidemiological studies, as well as core laboratory work for many clinical trials, especially trials related to heart disease. Most recently his lab has been participating in large, multi-cohort genomic studies such as CARe (NHLBI’s Candidate gene Association Resource; large-scale candidate genotyping), CHARGE (Cohorts for Heart and Aging Research in Genomic Epidemiology; GWAS), and ESP (NHLBI’s Exome Sequencing Program). His lab houses a large Biological Specimen Repository with ~4,000,000 samples, in >170 -80C or –145C freezers. Dr. Tracy’s research interests include the interrelationships of coagulation, fibrinolysis and inflammation, especially the innate and adaptive immune systems. He explores their roles in the etiology of atherosclerosis and coronary heart disease, insulin resistance and diabetes, HIV-related morbidity and mortality, and other complex disease settings, as well as more broadly in the process of aging. He has a long standing interest in disease risk modeling and risk assessment as well as in developing new biomarkers for clinical and epidemiological research. He also collaborates on studies of murine models of atherosclerosis and non-human primate models of HIV infection and AIDS.