Key Publications

David JJ, Subramanian SV, Zhang A, Willis WL, Kelm RJ Jr, Leier CV, Strauch AR. Y-box binding protein-1 implicated in translational control of fetal myocardial gene expression after cardiac transplant. Exp Biol Med (Maywood). 2012 May 1;237(5):593-607

Gurha P, Abreu-Goodger C, Wang T, Ramirez MO, Drumond AL, van Dongen S, Chen Y, Bartonicek N, Enright AJ, Lee B, Kelm RJ Jr, Reddy AK, Taffet GE, Bradley A, Wehrens XH, Entman ML, Rodriguez A. Targeted deletion of microRNA-22 promotes stress-induced cardiac dilation and contractile dysfunction. Circulation. 2012 Jun 5;125(22):2751-2761

Rumora AE, Steere AN, Ramsey JE, Knapp AM, Ballif BA, Kelm RJ Jr. Isolation and characterization of the core single-stranded DNA-binding domain of purine-rich element binding protein B (Purβ). Biochem Biophys Res Commun. 2010 Sep 24;400(3):340-345

van Rooij E, Quiat D, Johnson BA, Sutherland LB, Qi X, Richardson JA, Kelm RJ Jr, Olson EN. A family of microRNAs encoded by myosin genes governs myosin expression and muscle performance. Dev Cell. 2009 Nov;17(5):662-673

Ramsey JE, Kelm RJ Jr. Mechanism of strand-specific smooth muscle α-actin enhancer interaction by purine-rich element binding protein B (Purβ). Biochemistry. 2009 Jul 14;48(27):6348-6360

Zhang A, David JJ, Subramanian SV, Liu X, Fuerst MD, Zhao X, Leier CV, Orosz CG, Kelm RJ Jr, Strauch AR. Serum response factor neutralizes Pur alpha- and Pur beta-mediated repression of the fetal vascular smooth muscle alpha-actin gene in stressed adult cardiomyocytes. Am J Physiol Cell Physiol. 2008 Mar;294(3):C702-714

Knapp AM, Ramsey JE, Wang SX., Strauch AR, Kelm RJ Jr. Structure-function analysis of mouse Pur beta II: Conformation altering mutations disrupt single-stranded DNA and protein interactions crucial to smooth muscle alpha-actin gene repression. J Biol Chem. 2007 Dec 7;282(49):35899-35909

Ramsey JE, Daugherty MA, Kelm RJ Jr. Hydronamic studies on the quarternary structure of recombinant mouse Pur beta. J Biol Chem. 2007 Jan 19;282(3):1552-1560