Department research programs include clinical and basic investigations. A newly consolidated Clinical Neurotrials Unit is actively pursuing the development of experimental neurotherapeutics for a range of neurological disorders including: ALS and Peripheral Neuropathologies, Epilepsy, Migraine and other pain syndromes, Multiple Sclerosis, Neurodegenerative disorders including Alzheimer’s, Huntington’s, & Parkinson’s Disease, and Cerebellar Ataxias and Stroke.

Additional research in humans covers a range of areas: biomechanics of acupuncture; genetics and migraine, metabolic and nutritional aspects of neurodegenerative disorders, visual processing in neurodegenerative disorders and preventative strategies in cerebrovascular disease.

The Neuroscience Cluster has developed three main themes: developmental and molecular neuroscience; system neuroscience and neuroplasticity; and translational neuroscience-focusing on neurodegenerative and vascular brain disease, including animal models of human neurological diseases and disorders.

Neuroscience Center of Biomedical Research Excellence

The Neuroscience Center of Biomedical Research Excellence (COBRE), established in 2001 with funding from the National Institutes of Health, was created to integrate and expand neuroscience research and training at UVM by building a collaborative intellectual infrastructure, developing cutting-edge shared core facilities, and by providing research funding for neuroscience faculty, especially junior faculty, in multiple colleges.

Basic Science Research

Overall goals of the basic science faculty in the Department of Neurological Sciences are to gain an understanding of the fundamental mechanisms of neurological disorders and to facilitate the development of novel therapeutic approaches.

Clinical Trials

The Department of Neurological Sciences is actively conducting clinical research in several diseases. Faculty members are involved in treatment trials in ALS, Alzheimer’s Disease, Epilepsy, Migraine/headache, Multiple Sclerosis, Myasthenia Gravis, Neonatal Conditioning Responses, Pain, Parkinson's Disease, Polyneuropathy, Sleep and Cerebrovascular Disease.

This research involves Phase I, Phase II or Phase III studies under the clinical research activities of the Experimental Therapeutics Unit. The NIH funded General Clinical Research Center serves as an excellent resource for the conduct of some of these clinical trials.

Clinically applied research is also undertaken through the study in the mechanism of acupuncture in pain, use of stable isotope techniques to study metabolism and energy balance, and in establishing databases for several neurological diseases.

Summer Neuroscience Undergraduate Research Fellowship

These fellowships offer an exciting opportunity to join state-of-the-art laboratories and discover the world of neuroscience research. Students participate in investigations of how the nervous system develops, functions and repairs itself after injury; get hands-on training in molecular, cellular, anatomical, physiological approaches; and gain valuable experience before entering graduate or medical school.  Learn more