Department of Neurological Sciences

Calcium and Other Intracellular Messengers

David D. Friel, Hillel J. Chiel, Calcium dynamics: analyzing the Ca2+ regulatory network in intact cells, Trends in Neurosciences, Volume 31, Issue 1, January 2008, Pages 8-19, ISSN 0166-2236, 10.1016/j.tins.2007.11.004.

Beavo JA, Brunton LL., Cyclic nucleotide research -- still expanding after half a century. Nat Rev Mol Cell Biol. 2002 Sep;3(9):710-8.

Student led discussion

Imaging Calcium in Neurons Grienberger and Konnerth 2012 Neuron 73: 862-885

Live Cell Imaging of cAMP Dynamics Willoughby and Cooper 2008 Nature Methods 5: 29-36

Berridge et al, 2003. Calcium signalling: dynamics, homeostasis and remodelling. Nature Rev Molec Cell Biol 4:817

Sensory transduction through TRP Channels

Moran MM, McAlexander MA, Bíró T, Szallasi A. Transient receptor potential channels as therapeutic targets. Nat Rev Drug Discov. 2011 Aug 1;10(8):601-20.

Student led discussion

Wu, X et al. TRPC channels are necessary mediators of pathologic cardiac hypertrophy. PNAS 107:7000-7005, 2010

Bautista, DM et al. The menthol receptor TRPM8 is the principal detector of environmental cold. Nature 448:204-209, 2007.

Acetylcholine

"Cholinergic systems mediate action from movement to higher consciousness"
 Woolf NJ and Butcher LL. 2011. Brah Brain Res. 22: 488-498.

Student led discussion

Jason, Hal, Dave, Brendan:

Parikh et al 2010. Prefrontal beta2 subunit containing and alpha7 nicotinic acetylcholine receptors differentially control glutamatergic and cholinergic signaling. J. Neurosci. 30:3518-3530.

Meghan, Elliot, Nick, Eric:

Tian et al 2011. Plasticity of prefrontal attention circuitry: upregulated muscarinic excitability in response to decreased nicotinic signaling following deletion of α5 or β2 subunits. J Neurosci. 31:16458-63.

Glutamate

Glutamate, Rae Nishi, ANNB 323, September 20, 2012

Two review articles by Sarter are below. You may want to focus on the circuit diagrams to help solve some confusion from today's discussion.

Martin Sarter, Cindy Lustig, Stephan F. Taylor. Cholinergic contributions to the cognitive symptoms of schizophrenia and the viability of cholinergic treatments. Neuropharmacology, Volume 62, Issue 3, March 2012, Pages 1544–1553

Martin Sarter, Vinay Parikh, W. Matthew Howe. Phasic acetylcholine release and the volume transmission hypothesis: time to move on. Nat Rev Neurosci. 2009 May; 10(5): 383–390.

Review for Thursday's lecture:

Niciu et al, 2012. Overview of glutamatergic neurotransmission in the nervous system. Pharmacol Biochem Behav 100:656-664.

**Please Note: Class will be held in HSRF 200.**

Student led discussion

Papers for discussion

Elliot Marks, Eric Gonzalez, Brendan Hare:

Govindaiah G, Wang T,Gillette MU, Cox CL. Activity-Dependent Regulation of Retinogeniculate Signaling by Metabotropic Glutamate Receptors. The Journal of Neuroscience, 12 September 2012, 32(37):12820-12831.

Jason Fuchs, Hal Bauerle, Nick Ortiz:

Wang CC, Held RG, Chang SC, Yang L, Delpire E, Ghosh A, Hall BJ. A Critical Role for GluN2B-Containing NMDA Receptors in Cortical Development and Function. Neuron, Volume 72, Issue 5, 8 December 2011, Pages 789-805.

Dave Harris, Meghan Eddy:

Choi KH, Edwards S, Graham DL, Larson EB, Whisler KN, Simmons D, Friedman AK, Walsh JJ, Rahman Z, Monteggia LM, Eisch AJ, Neve RL, Nestler EJ, Han MH, Self DW. Reinforcement-Related Regulation of AMPA Glutamate Receptor Subunits in the Ventral Tegmental Area Enhances Motivation for Cocaine. The Journal of Neuroscience, 25 May 2011, 31(21): 7927-7937.

Sept. 27 -

HSRF 200

GABA

Gassman M and Bettler B. 2012. Regulation of neuronal GABA-B receptor functions by subunit composition. Nat Neurosci Rev 13: 380-394

Luscher et al. 2011. GABA-A receptor trafficking-mediated plasticity of inhibitory synapses. Neuron 70: 385-409.

*Please note class will be held in HSRF 200*

Student led discussion

Papers for discussion

Elliot Marks:

Wu X., Fu Y., Knott G., Lu J., Di Cristo G., and Huang Z.J. (2012).GABA Signaling Promotes Synapse Elimination and Axon Pruning in Developing Cortical Inhibitory Interneurons. J Neurosci., 32(1):331-343.

Brendan Hare:

Ren, Q., Li, H., Wu, Y., Ren, J., & Guo, A. (2012). A GABAergic inhibitory neural circuit regulates visual reversal learning in Drosophila. The Journal of neuroscience: the official journal of the Society for Neuroscience, 32(34), 11524–11538. doi:10.1523/JNEUROSCI.0827-12.2012

Eric Gonzalez:

Leil TA, Chein ZW, Chang CSS, Olsen RW (2006) GABAa receptor-associated protein traffics GABAa receptors to the plasma membrane in neurons, The Journal of Neuroscience, 24(50): 11429-11438.

Meghan Eddy:

Differential effects of GABAB receptor subtypes, γ-hydroxybutyric acid, and baclofen on EEG activity and sleep regulation. Vienne, J. et al. (2010). J. Neurosci. 30:14194-14204.

Dave Harris:

"5GABAA Receptor Activity Sets the Threshold for Long-Term Potentiation and
 Constrains Hippocampus-Dependent Memory" by Martin, et al., 2010. Journal of Neuroscience

Hal Bauerle:

Tretter, V., Jacob, T.C., Mukherjee, J., Fritschy, J.M., Pangalos, M.N., and Moss, S.J. (2008). The clustering of GABA(A) receptor subtypes at inhibitory synapses is facilitated via the direct binding of receptor alpha 2 subunits to gephyrin. J. Neurosci. 28, 1356–1365.

Nick Ortiz:

Ariwodola, O. J., & Weiner, J. L. (2004). Ethanol potentiation of GABAergic synaptic transmission may be self-limiting: role of presynaptic GABA(B) receptors. The Journal of Neuroscience, 24(47), 10679–86.

Jason Fuchs:

Kawaguchi,Shin-ya, & Hirano, Tomoo. Sustained Structural Change of GABAA Receptor-Associated Protein Underlies Long-Term Potentiation at Inhibitory Synapses on a Cerebellar Purkinje Neuron. The Journal of Neuroscience, 20 June 2007, 27(25): 6788-6799

Biogenic amines

Lemos, J.C. et al (2012) Severe stress switches CRF action in the nucleus accumbens from appetitive to aversive. Nature, doi:10.1038/nature11436

Threlfell S, et al (2012) Striatal Dopamine Release Is Triggered by Synchronized Activity in Cholinergic Interneurons. Neuron 75, 58–64

Adenosine, ATP, and Purinergic Signaling

Burnstock, G., Krügel, U., Abbracchio, MP., Illes,  P. Purinergic signalling: from normal behaviour to pathological brain function. Prog Neurobiol. 2011 Oct; 95(2):229-74. Epub 2011 Sep 1.

Student led discussion

Goldman N, Chen M, Fujita T, Xu Q, Peng W, Liu W, Jensen TK, Pei Y, Wang F, Han X, Chen JF, Schnermann J, Takano T, Bekar L, Tieu K, Nedergaard M. Adenosine A1 receptors mediate local anti-nociceptive effects of acupuncture. Nat Neurosci. 2010 Jul;13(7):883-8.

Serrano A, Mo G, Grant R, Paré M, O'Donnell D, Yu XH, Tomaszewski MJ, Perkins MN, Séguéla P, Cao CQ. Differential expression and pharmacology of native P2X receptors in rat and primate sensory neurons. J Neurosci. 2012 Aug 22;32(34):11890-6.

Inflammatory mediators

Rivest S. Regulation of innate immune responses in the brain. Nat Rev Immunol. 2009 Jun;9(6):429-39

Student led discussion

Hal Bauerle:

Richard K, Filali M, Préfontaine P, Rivest S. Toll-Like Receptor 2 Acts as a Natural Innate Immune Receptor to Clear Amyloid β1–42 and Delay the Cognitive Decline in a Mouse Model of Alzheimer's Disease. (2008) J Neurosci. 28(22): 5784-5793

Meghan Eddy:

Chen GQ, Chen YY, Wang XS, Wu SZ, Yang HM, Xu HQ, He JC, Wang XT, Chen JF, Zheng RY (2010) Chronic caffeine treatment attenuates experimental autoimmune encephalomyelitis induced by guinea pig spinal cord homogenates in Wistar rats. Brain Res. 1309:116-25

Eric Gonzalez:

Scholtzova H, Kascsak RJ, Bates KA, Boutajangout A, Kerr DJ, Meeker HC, Mehta PD, Spinner DS & Wisniewski DS. (2009) Induction of toll-like receptor 9 signaling as a method for ameliorating Alzheimer's Disease-related pathology. The Journal of Neuroscience, 29: 1846-1854.

Dave Harris:

Brendan Hare:

Tsai VWW, Mohammad MG, Tolhurst O, Breit SN, Sawchenko PE, Brown DA. (2011) CCAAT/enhancer binding protein-δ expression by dendritic cells regulates CNS autoimmune inflammatory disease. J Neurosci. 31(48), 17612–17621

Jason Fuchs:

Zozulya, A. L., Ortler, S., Lee, J., Weidenfeller, C., Sandor, Wiendl, H., & Fabry, Z. (2009). Intracerebral dendritic cells critically modulate encephalitogenic versus regulatory immune responses in the CNS. The Journal of Neuroscience, 29(1), 140-152.

Elliot Marks:

Cramer P. et al (2012) ApoE-Directed Therapeutics Rapidly Clear β-Amyloid and Reverse Deficits in AD Mouse Models. Science. 335:1503-1506

Nick Ortiz:

Simard AR, Soulet D, Gowing G, Julien JP, Rivest S (2006) Bone marrow-derived microglia play a critical role in restricting senile plaque formation in Alzheimer’s disease. Neuron, 49(4), 489–502.

Neurotrophic factors

da Silva S, Wang F. (2011) Retrograde neural circuit specification by target-derived neurotrophins and growth factors. Curr Opin Neurobiol. 21(1):61-7. Epub 2010 Aug 31.

Student led discussion

Barak S, Ahmadiantehrani S, Kharazia V, Ron D. (2011) Positive autoregulation of GDNF levels in the ventral tegmental area mediates long-lasting inhibition of excessive alcohol consumption. Transl Psychiatry. 2011;1. pii: e60

Ling Ma, Dong-Dong Wang, Tian-Yi Zhang, Hui Yu, Yue Wang, Shu-Hong Huang, Francis S. Lee, and Zhe-Yu Chen (2011) Region-Specific Involvement of BDNF Secretion and Synthesis in Conditioned Taste Aversion Memory Formation. The Journal of Neuroscience. 31(6): 2079-2090

Park K, Luo JM, Hisheh S, Harvey AR, Cui Q (2004) Cellular Mechanisms Associated with Spontaneous and Ciliary Neurotrophic Factor-cAMP-Induced Survival and Axonal Regeneration of Adult Retinal Ganglion Cells. J Neurosci. 24(48):10806-15

Nov. 15-

HSRF 200

Drugs of Abuse: Nicotine, Opiates, Alcohol

*Please note class will be held in HSRF 200*

Kenny PJ (2011) Common cellular and molecular mechanisms in obesity and drug addiction. Nat Rev Neurosci. 12(11):638-51

Mandyam CD, Koob GF (2012) The addicted brain craves new neurons: putative role for adult-born progenitors in promoting recovery. Trends Neurosci. 35(4):250-60.

Student led discussion

Meghan & Brendan:

Schwarz et al. (2011) Early-life experience decreases drug-induced reinstatement of morphine CPP in adulthood via microglial-specific epigenetic programming of anti-inflammatory IL-10 expression. J. Neurosci. 31(49): 17835-17847

Dave & Jason:

Romieu P, Host L, Gobaille S, Sandner G, Aunis D, Zwiller J. (2008). Histone deacetylase inhibitors decrease cocaine but not sucrose self-administration in rats. The Journal of Neuroscience, 28(38), 9342-9348.

Nick & Hal:

Fowler et al. (2011) Habenular α5* nicotinic receptor signaling controls nicotine intake. Nature. 471(7340): 597–601.

Eric & Elliot:

Oliva JM, Manzanares J. (2007) Gene Transcription Alterations Associated with Decrease of Ethanol Intake Induced by Naltrexone in the Brain of Wistar Rats. Neuropsyhopharmacology, 32: 1358-1369.

Student led discussion

Brendan Hare:

Zagrebelsky M, Schweigreiter R, Bandtlow CE, Schwab ME, Korte M. (2010) Nogo-A Stabilizes the Architecture of Hippocampal Neurons. The Journal of Neuroscience. 30(40): 13220-13234

Jason Fuchs:

Dickson H, Zurawski J, Zhang H, Turner D, Vojtek A. (2010) POSH is an Intracellular Signal Transducer for the Axon Outgrowth Inhibitor Nogo66. The Journal of Neuroscience. 30(40): 13319-13325

Dave Harris:

Cafferty WBJ, Duffy P, Huebner E, Strittmatter S. (2010) MAG and OMgp Synergize with Nogo-A to Restrict Axonal Growth and Neurological Recovery after Spinal Cord Trauma. The Journal of Neuroscience.30(20): 6825-6837

Meghan Eddy:

Omoto S, Ueno M, Mochio S, Takai T, Yamashita T. (2010) Genetic Deletion of Paired Immunoglobulin-Like Receptor B Does Not Promote Axonal Plasticity or Functional Recovery after Traumatic Brain Injury. The Journal of Neuroscience.30(39): 13045-13052

Eric Gonzalez:

Zai et al. (2011) Inosine Augments the Effects of a Nogo Receptor Blocker and of Environmental Enrichment to Restore Skilled Forelimb Use after Stroke. The Journal of Neuroscience.31(16): 5977-5988

Nick Ortiz:

Raiker SJ, Lee H, Baldwin KT, Duan Y, Shrager P, Giger RJ. (2010) Oligodendrocyte-myelin glycoprotein and Nogo negatively regulate activity-dependent synaptic plasticity. J Neurosci.30(37):12432-45

Elliot Marks:

Dickendesher TL et al. (2012) NgR1 and NgR3 are receptors for chondroitin sulfate proteoglycans. Nat Neurosci.15(5):703-12

Hal Bauerle:

Lu, P. et al. (2012). Long-Distance Growth and Connectivity of Neural Stem Cells after Severe Spinal Cord Injury. Cell, 150(6), 1264–1273. doi:10.1016/j.cell.2012.08.020