Matthew E. Poynter, Ph.D.

Associate Professor
University of Vermont, Department of Medicine, Division of Pulmonary Disease and Critical Care

Given E410A
University of Vermont, College of Medicine
149 Beaumont Ave.
Burlington, VT. 05405

Office: 802-656-8045
Lab: 802-656-8046

Email: matthew.poynter@uvm.edu

• B.S. (1993) Microbiology, Montana State University, Bozeman, MT
• Ph.D. (1998) Experimental Pathology, Cell Biology and Immunology, University of Utah, Salt Lake City, UT
• Post-doc. (1998-2002) Department of Pathology, University of Vermont, Burlington, VT
• Research Assistant Professor (2002-Present) Department of Medicine, University of Vermont, Burlington, VT

• Intracellular signaling cascades activated in airway epithelial cells in response to bacterial products, cytokines, allergens, cationic proteins, and the oxidant gas, nitrogen dioxide
• NF-kappaB (NF-kB) and cJun N-terminal kinase (JNK) pathways, leading to transcriptional upregulation of inflammatory cytokines and enzymes, pro- and anti-apoptotic genes, and augmented expression of numerous other immunomodulatory proteins
• Mouse models of Asthma and Cystic Fibrosis
• in vitro manipulation of murine and human cell lines
• It is the lab's objective to elucidate the triggers and consequences of these intracellular signaling cascades in order to provide a better understanding of the roles of the airway epithelium in health and disease

• Measurement of oxidant-induced signal transduction proteins using cell imaging. Free Radical Biology and Medicine, 27(11/12): 1164-1172 (1999).
   
   
• Recent advances towards understanding redox mechanisms in the activation of nuclear factor kappa-B. Free Radical Biology and Medicine, 28(9): 1317-1327 (2000).
   
   
• Molecular mechanisms of nitrogen dioxide induced epithelial injury in the lung. Molecular and Cellular Biochemistry, 234/235: 71-80 (2002).
   
   
• Rapid activation of nuclear factor-kB in airway epithelium in a murine model of allergic airway inflammation. American Journal of Pathology 160(4): 1325-1334 (2002).
   
   
• Reactive nitrogen species and cell signaling: Implications for death or survival of lung epithelium. American Journal of Respiratory and Critical Care Medicine, 166(12 Pt 2): S9-S16 (2002).
   
   
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