Cancer Translational Research Laboratory

The University of Vermont Cancer Center – Cancer Translational Research Laboratory (CTRL) was established in January of 2014 to support a component of the UVM Cancer Center mission; to improve the development of collaborative transdisciplinary partnerships between scientists and physician investigators.

The CTRL is a shared resource that provides services to members of the University of Vermont Cancer Center (UVMCC) to support the initiation and development of translational research projects in early phases of the cancer translational research continuum; projects that encompass basic, clinical, and population health science research.

Purpose

It is the duty of the CTRL to minimize the barriers that have traditionally impeded translation. We provide a mentored laboratory research environment complete with highly trained personnel and needed research resources otherwise unavailable to clinicians eager to participate in early phase studies, and the delivery of human subject resources to basic scientists interested in determining the clinical relevance of their laboratory findings. 

Typical transdisciplinary translational research projects supported by the CTRL include:

  • Biomarker, target discovery and detection assay development
  • Preclinical treatment testing & development
  • Personalized medicine & clinical tumor response
  • Population and behavior health science

Services

The services provided by the CTRL are completely customized to meet the needs of each clinical investigator. We provide:

  • A BSL-2 certified laboratory equipped to perform:
    • Specimen processing
    • Cryopreservation & sample management
  • Equipment & materials for customized molecular biology/biochemical evaluation
    • Immunohistochemisty
    • Gene expression analysis
    • In vitro/in vivo drug candidate testing
  • A contemporary tissue culture suite
    • Cell-based studies
    • Virus-based vector production
    • A Collection of ATCC, and annotated, patient-derived tumor cell lines available upon request

Additional services can be tailored and provided based on individual need. The CTRL strives to maximize the cost benefit of each project by partnering with the other shared resources on campus so as to avoid service redundancies within the shared resource network.

Access

Access to the CTRL is gained through competitive award opportunities available through the UVM Cancer Center termed the Collaborative Cancer Translational Research Grant (UVMCC-CCTRG) that fund early-stage collaborative translational research projects that require CTRL involvement.

Features of the UVMCC-CTRG:

  • Rolling application deadlines
  • Application process involves:
    • consultation with the CTRL Director and Directors of UVMCC/VGN core facilities
    • Identify/refine testable hypotheses
    • Draft appropriate aims
    • Pinpoint resources, limitations, budget
    • Identify suitable collaborators
  • Applications are reviewed by an independent advisory board
  • Additional details available on the Collaborative Cancer Translational Research Grant Program page.

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Location: Given E-213
Phone: (802) 656-3776

Personnel

Jon Ramsey, PhD, Director
Zhihua Peng, PhD, Technical