Education
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MS - University of Vermont, Physiology & Biophysics, 1970
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PhD - University of Vermont, Cell Biology, 1977
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Expertise
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Environmental toxicology, epithelial cell differentiation, chemical and physical carcinogenesis and cell injury, pulmonary fibrosis, oxygen free radicals, molecular biology of antioxidant enzymes in lung, cell signaling
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Academic Appointments
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1995 - Director, Environmental Pathology Program, University of Vermont
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1995 - 1998 Program Leader, Cell Signaling and Growth Control Research Program, Vermont Cancer Center
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1992 - Professor, Department of Pathology, University of Vermont
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1989 - Adjunct Faculty Member, In Vitro Cell Biology and Biotechnology Program, State University of New York, Plattsburgh, NY
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1984 - 1992 Associate Professor, Department of Pathology, University of Vermont
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1984 - 1988 Chair, Cell and Molecular Biology Program, University of Vermont
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1980 - 1983 Assistant Professor, Department of Pathology, University of Vermont
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1978 - 1980 Research Assistant Professor, Department of Pathology, University of Vermont
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1975 - 1977 Research Associate, Department of Pathology, University of Vermont
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1973 - 1974 Research Assistant, Department of Pathology, University of Vermont
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1970 - 1973 Research Assistant, Institute of Environmental Medicine, New York Univ, Sterling Forest, NY
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1968 - 1970 Research Assistant, Department of Obstetrics & Gynecology, University of Vermont
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1968 - 1970 Graduate Student, Physiology and Biophysics, University of Vermont
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Publications
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Ramos-Nino ME, Blumen SR, Sabo-Attwood T, Gell J, Pass H, Carbone M, Testa J, Altomare DA, Heintz N, and Mossman BT: HGF mediates cell proliferation on human mesothelioma cells through a PI3K/MEK5/ Fra-1 pathway. Am J Respir Cell Mol Biol 38:209-217, 2008.
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Blumen SR, Cheng K, MacPherson MB, Ramos-Nino ME, James TA, Taatjes DJ, Landry CC, and Mossman BT: Acid-prepared mesoporous spheres (APMS) increase efficacy of doxorubicin transfer and toxicity in human mesothelioma cells. (Submitted).
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Levis J, Loi R, Butnor KJ, Vacek P, Steele C, Mossman BT, and Weiss DJ: Decreased asbestos-induced lung inflammation and fibrosis following irradiation and bone marrow transplantation. Am J Respir Cell Mol Biol 38:16-25, 2008.
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Haegens A, Vernooy JHJ, Heeringa P, van Suylen R-J, Steele C, Mossman BT, and Wouters EFM: Myeloperoxidase deficiency attenuates LPS induced acute lung inflammation and injury. Eur Respir J 31:252-260, 2008.
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Mossman BT: Fiber and Particle Carcinogenesis. In: The Molecular Basis of Human Cancer (WB Coleman and GJ Tsongalis eds.), Humana Press, Inc., Totowa, NJ, 2nd Ed., (In progress).
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Buder-Hoffmann SA, Shukla A, Barrett TF, Lounsbury KM, and Mossman BT: A PKCd-dependent PKD pathway modulates ERK1/2 and JNK1/2 phosphorylation and Bim-induced apoptosis by asbestos. Am J Pathol (In preparation).
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Swain WA, Barrett TF, MacPherson MB, Gell JJ, O’Byrne KJ, Houghton CE, Ramos-Nino ME, Testa JR, Faux SP, and Mossman BT: Asbestos activates EGFR-dependent PI3K/AKT and ERK1/2 survival pathways in human mesothelial cells that trigger a JNK-mediated death pathway. Cancer Res (Submitted).
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Fukagawa NK, Li M, Sabo-Attwood T, Timblin CR, Butnor KJ, Gagne J, Steele C, Taatjes DJ, Huber S, and Mossman BT: Airborne pathogenic particulates exacerbate atherosclerosis in ApoE-deficient mice via CD4+ T cells (Submitted).
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Dostert C, Pétrilli V, Van Bruggen R, Steele C, Mossman BT, and Tschopp J: Innate immune activation through Nalp3 inflammasome sensing of asbestos and silica. Science Apr 10 [Epub ahead of print], 2008.
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Haegens A, Vernooy JHJ, Cloots RHE, Kelders MCJM, Drummen NEA, Xanthoulea S, Bast A, Fehrenbach H, Poynter ME, Mossman BT, and Wouters EFM: Myeloperoxidase attenuates LPS-induced airspace enlargement. Am J Respir Cell Mol Biol (Submitted).
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Heintz NH and Mossman BT: Molecular responses to asbestos: induction of cell proliferation and apoptosis via modulation of redox-dependent signaling pathways. In: Asbestos and Its Diseases, JE Craighead and A Gibbs, eds.), Oxford University Press, Oxford, UK (In Press).
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Blumen SR, Cheng K, Hillegass J, MacPherson MB, Alexeeva V, Ramos-Nino ME, Shukla A, James TA, Weiss DJ, Taatjes DJ, Landry CC, and Mossman BT: Delivery of doxorubicin by acid-prepared mespoprous spheres increases expression of DNA damage and response genes and human mesothelioma cell death. Mol Cancer Ther (Submitted).
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Ramos-Nino ME, Blumen SR, Sabo-Attwood T, Gell J, Pass H, Carbone M, Testa J, Altomare DA, Heintz N, and Mossman BT: HGF mediates cell proliferation on human mesothelioma cells through a PI3K/MEK5/ Fra-1 pathway. Am J Respir Cell Mol Biol 38:209-217, 2008.
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Barlow CA, Kitiphongspattana K, Siddiqui N, Roe MW, Mossman, BT, and Lounsbury KM: Protein kinase A-mediated CREB phosphorylation is an oxidant-induced survival pathway in alveolar type II cells. Apoptosis 13:681-692, 2008.
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O’Hara KA, MacPherson MB, Manning NA, Klei LR, Mossman BT, and Barchowsky A: Persistent co-localization of activates Src family kinases and mitogen-activated protein kinases in airway epithelial cells following in vivo exposure to chromium (VI). Toxicol Sci (In revision).
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Mossman BT: Assessing nanotixicity by detecting toxicity to cells. In: Wiley Interdisciplinary Reviews: Nanomedicine (ed.) John Wiley & Sons, Inc., Hoboken NJ, (In progress).
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Mossman BT, Borm PJ, Castranova V, Costa DL, Donaldson K, and Kleeberger SR: Meeting proceedings: mechanisms of action of inhaled fibers, particles, and nanoparticles in lung and cardiovascular diseases. (On-line journal) .
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Janssen-Heininger YMW, Mossman, BT, Heintz NH, Forman H, Kalyanaraman B, Stamler JS, and van der Vliet A: Redox regulation of signal transduction: principles, pitfalls, and promises (Invited Review). Free Radic Biol Med. (In Press), 2008.
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Manning CB, Sabo-Attwood T, Robledo RF, Rincon M, Shukla A, Ramos-Nino M, Vacek P, Hemenway D, Taatjes DJ, and Mossman BT: Transgenic interruption of the extracellular signal-regulated kinase (ERK1/2) cascade in vivo inhibits proliferation and alters differentiation of bronchiolar epithelium after asbestos injury, Am J Pathol (In Revision).
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Stevens JP, Zahardis J, MacPherson M, Mossman BT, and Petrucci GA: A new method for quantifiable and controlled dosage of particulate matter for in vitro studies: the Electrostatic Particulate Dosage and Exposure System (EPDExS). In Vitro Toxicol (In preparation).
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Blumen SR and Mossman BT: Chemical and environmental agents in the pathogenesis of lung cancers and mesothelioma. In: Molecular Pathology of Lung Disease, (P Cagle, DS Zander, J Jagirdar, R Barrios, A Haque, and H Popper, eds.), Springer-Verlag, New York, NY (In Press).
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Cheng K, Blumen SR. MacPherson MB, Weiss DJ, JAme TA, Mossman BT, and Landry CC: Targeted uptake of bifunctionality modified nanoporous particles by malignant mesothelioma cells. Nature Nanomed (In preparation).
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Shukla A, MacPherson MB, Hillegass J, Ramos-Nino ME, Alexeeva V, Vacek PM, Bond JP, and Mossman BT: Increased alterations in gene expression in human mesothelial cells correlate with mineral toxicity and pathogenicity. Am J Respir Cell Mol Biol (Submitted).
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Barlow C, Shukla A, Mossman B, and Lounsbury K: Asbestos-mediated CREB phosphorylation is regulated by protein kinase A and extracellular signal regulated kinases 1/2. Am J Physiol: Lung Cell Mol Physiol 292:L1361-L1369, 2007.
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Mossman, BT, Shukla A, and Fukagawa, NK: A highlight on “Oxidative stress and lipid mediators induced in alveolar macrophages by ultrafine particles” Free Radic Biol Med 43:504–505, 2007
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Blumen SR, Cheng K, Ramos-Nino ME, Taatjes DJ, Weiss DJ, Landry CC, and Mossman BT: Unique uptake of acid-prepared mesoporous spheres by lung epithelial and mesothelioma cells. Am J Respir Cell Mol Biol 36:333-342, 2007.
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Ramos-Nino ME, Blumen SR, and Mossman BT: Fra-1 governs cell migration via modulation of CD44 expression in human mesotheliomas. (On-line journal) http://www.molecular-cancer.com/content/6/1/81 Mol Cancer 6:81, 2007.
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Haegens A, Barrett TF, Gell J, Shukla A, MacPherson M, Vacek P, Poynter ME, Butnor KJ, Janssen-Heininger YM, Steele C, and Mossman BT: Airway epithelial NF-?B activation modulates asbestos-induced inflammation and mucin production in vivo. J Immunol 178:1800-1808, 2007.
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Barlow C, Shukla A, Mossman B, and Lounsbury K: Asbestos-mediated CREB phosphorylation is regulated by protein kinase A and extracellular signal regulated kinases 1/2. Am J Physiol: Lung Cell Mol Physiol 292:L1361-L1369, 2007.
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Shukla A, Lounsbury KM, Barrett TF, Gell J, Rincón M, Butnor KJ, Taatjes DJ, Davis GS, Vacek P, Nakayama KI, Nakayama K, Steele C, and Mossman BT: Asbestos-induced peribronchiolar cell proliferation and cytokine production are attenuated in lungs of protein kinase C-delta knockout mice. Am J Pathol 170:140-151, 2007.
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Blumen SR, Cheng K, Ramos-Nino ME, Taatjes DJ, Weiss DJ, Landry CC, and Mossman BT: Unique uptake of acid-prepared mesoporous spheres by lung epithelial and mesothelioma cells. Am J Respir Cell Mol Biol 36:333-342, 2007.
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Mossman BT: Assessment of the pathogenic potential of asbestiform vs. nonasbestiform particulates (cleavage fragments) in in vitro (cell or organ culture) models and bioassays. Regul Toxicol Pharmacol Oct 11 [Epub ahead of print], 2007.
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Levis JE and Mossman BT: Cell signaling pathways elicited by particulates. In: Particle Toxicology, (K Donaldson and P Borm, eds.), CRC Press, Inc., Boca Raton, FL, 197-209, 2007.
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