Developing a mouse model of morphine treatment for studying the effects of long-term opioid use on fracture risk
Katherine J. Motyl, PhD
Faculty Scientist I, MMCRI │ Assistant Professor, Tufts University School of Medicine │ Full Graduate Faculty, Graduate School of Biomedical Sciences and Engineering, University of Maine
Clinically, opioid prescription is associated with increased fracture risk and pharmacoepidemiological studies indicate that combining opioids with other prescription drugs exacerbates that risk. To test biological mechanisms of these findings, we developed a mouse model for bone loss associated with opioid use that has characteristics of the human condition. This unique interdisciplinary work spans fields of bone biology, pain and endocrinology to test physiologic and molecular mechanisms of this highly relevant problem.
Contact Nick Farina
Program will be livestreamed from Maine Medical Center.
Next Seminar Series program is April 10.