The Role of Tumor-associated Mesenchymal Cells in Breast Cancer Progression and Intervention
Jonathan Gordon, PhD, Assistant Professor, Department of Biochemistry, UVM
Many tumors are associated with a surrounding cell layer that while not cancerous, can contribute to progression of cancer to a metastatic state. Using a multipronged RNAseq-based strategy, a distinct population of mesenchymal stromal cells were identified in patients with invasive breast cancer.
The identified tumor-associated mesenchymal stromal cells may provide a therapeutic strategy to prevent metastatic bone disease and identify indicators of progression in primary tumors.
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