Area of Interest
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Cerebrovascular disease and stroke
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Hypertension in pregnancy as it relates to cerebrovascular function and eclampsia
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Education
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1997: Ph.D. Cell and Molecular Biology, University of Vermont College of Medicine, Burlington, Vermont. Dissertation: The actin cytoskeleton in vascular smooth muscle mechanotransduction.
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1994: M.S. Cell and Molecular Biology, University of Vermont College of Medicine, Burlington, Vermont. Dissertation: Cellular growth and remodeling of the uterine circulation during pregnancy
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1988: B.S. Electrical Engineering, Minor: Biomedical Engineering, University of Vermont College of Engineering and Math, Burlington, Vermont
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Appointments
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2008-present: Professor of Neurology, University of Vermont College of Medicine
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2005-2008: Associate Professor of Neurology, University of Vermont College of Medicine
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2002-present: Member, Graduate College - University of Vermont
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2002-2005: Assistant Professor of Neurology, Department of Neurology, University of Vermont College of Medicine
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1999-2002: Assistant Professor of Obstetrics and Gynecology, Department of Obstetrics and Gynecology, University of Vermont College of Medicine
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1999-present: Joint appointments in Ob/Gyn & Reproductive Science and Pharmacology, University of Vermont College of Medicine
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1997-1999: Assistant Professor of Surgery, Department of Surgery, Division of Vascular Surgery, Oregon Health Sciences University, Portland, OR
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Professional Activities
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2007-present: Editorial Board, Stroke
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2006-present: Editorial Board for Journal Cerebral Blood Flow Metabolism
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2001-present: Member, Microcirculatory Society
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2000-present: Member, Perinatal Research Society
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2000-present: Member, International Society of Cerebral Blood Flow and Metabolism
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2000-present: Member, Society for Gynecologic Investigation
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1999-present: Member, Society for Neuroscience, National and Local Affiliate
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1997-present: Member, American Physiological Society
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1997-present: Member, American Society for Cell Biology
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1994-present: Member and Fellow, American Heart Association Council on High Blood Pressure Research, Basic Science, Circulation and Stroke Council
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Ad Hoc Reviewer:
American Journal of Physiology
Autonomic Neuroscience
Biology of the Neonate
Cardiovascular Diabetology
Cardiovascular Research
Clinical Endocrinology
Circulation
European Journal of Physiology
Journal of Applied Physiology
Journal of Cerebral Blood Flow and Metabolism
Journal of Laboratory and Clinical Medicine
Journal of Vascular Surgery
Metabolism Hypertension
Neurology
Pediatric Research
Stroke
Journal of Neurology
Experimental Physiology
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Awards and Honors
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2009: President elect, Perinatal Research Society
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2008: Research Committee, AHA Founder’s Affiliate
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2007: Fellow, Cardiovascular Section of American Physiological Society
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2006: Society for Gynecologic Investigation President’s Presentation Award
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2004: Established Investigator for the American Heart Association
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2001: Fellow of the American Heart Association Council on High Blood Pressure Research
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1999-present: Fellow for the Totman Center for Cerebrovascular Research
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1999: Young Investigator Award for the Perinatal Research Society
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Research
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Project Period: February 1, 2009 - March 31, 2014
Type: RO1 (NS045940)
Title: Cerebrovascular Function during Pregnancy and Hypertension
PI: Marilyn J. Cipolla, Ph.D.
Agency: National Institute of Neurologic Disorders and Stroke
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Project Period: July 1, 2005 - June 30, 2010
Type: RO1 (NS043316)
Title: Cerebral Arteriole Function during Hyperglycemic Stroke
PI: Marilyn J. Cipolla, Ph.D.
Agency: National Institute of Neurologic Disorders and Stroke
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Project Period: Jan.1, 2005 - Dec. 31, 2009
Type: Established Investigator Award (0540081N)
Title: Cerebrovascular Function During Pregnancy and Acute Hypertension
PI: Marilyn J. Cipolla, Ph.D.
Agency: American Heart Association
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Project Period: Jan. 1, 2009 - Dec. 31, 2010
Type: Vision Grant
PI: Laurie Amburgey, MD
Role: Sponsor
Agency: Preclampsia Foundation
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Publications
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Cipolla MJ, Smith J, Kohlmeyer MM, Godfrey JA: SKCa and IKCa channels, myogenic tone and vasodilator responses in middle cerebral arteries and parenchymal arterioles: Effect of ischemia and reperfusion. Stroke 40:1451-1457, 2009
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Euser AG and Cipolla MJ: Magnesium sulfate for treatment of eclampsia: A brief review. Stroke 40:1169-1175, 2009
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Cipolla MJ and Bullinger, LV: Reactivity of penetrating brain parenchymal arterioles during ischemia and reperfusion. Microcirculation 15:495-501. 2008
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Euser AG, Bulinger LV and Cipolla MJ: Magnesium sulfate decreases blood-brain barrier permeability furing acute hypertension in pregnant rats. Exp Physiol 93(2):2:54-61. 2008
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Cipolla MJ, Jeremiah Smith, Nicole Bishop, Lisa V. Bullinger and Julie Godfrey: Pregnancy reverses hypertensive remodeling of cerebral arteries. Hypertension 51(4):1052-1057, 2008
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Aukes AM, Vitullo L, Zeeman G, Cipolla MJ: Pregnancy prevents hypertension-induced remodeling and diminishes myogenic reactivity of posterior cerebral arteries in Dahl Salt Sensitive rats: Role in eclampsia? AM J Physiol 292(2): H1071-H1076, 2007
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Maneen MJ and Cipolla MJ: Peroxynitrite and myogenic tone of ceregral arteries: Effect of nitrosylation and F-actin. AM J Physiol 292(2): H1042-H1050, 2007
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Euser AG and Cipolla M: Cerebral blood flow autoregulation and edema formation during pregnancy in anesthetized rates. Hypertension 29(2):334-40, 2007
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Cipolla MJ: Brief review: Cerebrovascular funtion during pregnancy and eclampsia. Hypertension 50(1):14-24. 2007
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Maneen M, Hannah R, Vitullo L, Hoyniak N and Cipolla M: Peroxynitrite diminishes myogenic tone and promotes loss of reactivity in rat posterior cerebral arteries. Stroke, 37(3):894-899, 2006
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Cipolla MJ, DeLance N and Vitullo L: Pregnancy prevents hypertensive remodeling of cerebral arteries: a potential role in the development of eclampsia. Hypertension 47(3):619-626, 2006
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Euser A and Cipolla MJ: Resistance artery vasodilation to magnesium sulfate during pregnancy and the postpartum state. Am J Physiol 288:H1521-H1525, 2005
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Cipolla MJ, Vitullo L, DeLance N, and Hammer E: The cerebral endothelium during pregnancy: A potential role in the development of eclampsia. Endothelium 12:1-5, 2005
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Goodrow G, Vitullo L and Cipolla MJ: The effect of estrogen replacement therapy on middle cerebral artery function during stroke. Menopause 12(1):99-109, 2005
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Quick AM and Cipolla MJ: Pregnancy-induced upregulation of aquaporin-4 protein in brain and its role in eclampsia. FASEB J 19(2):170-175, 2005
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