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Our research program aims to understand how genetic variants that cause epilepsy, and other neurological diseases, impact synaptic function and intrinsic excitability, and how these neuronal changes lead to aberrant network activity and seizures. Our guiding hypothesis is that changes in synaptic and membrane function are key events in the pathway that leads from a genetic abnormality to disease phenotypes and that identifying these changes and their impact on neural circuit function are essential for a basic understanding of normal and pathological brain function. To achieve this, our lab interrogates functional alterations in genetic mouse models of epilepsy using imaging and electrophysiology techniques, both in vitro and in awake, behaving mice.




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