Grants, Abstracts, Publications & Honors

Publications

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Grants - Ongoing Research Support

* Indicates peer-reviewed by panels of national experts (National Institutes of Health, Department of Defense).

* Department of Defense/ The Henry M. Jackson Foundation for the Advancement of Military Medicine (HU001-18-2-0016 PI: Daniel Perl)

Subcontract to the University of Vermont      (Co-PIs Kalev Freeman, Mark Nelson)

9/1/2018-7/30/22 $142,505 (Vermont annual direct costs)

Cardiovascular Consequences of Traumatic Brain Injury

Role: Co-Principal Investigator (10%FTE)

Brief description: The thrust of the overarching research project at the Uniformed Services University for the Health Sciences is to study the pathologic and physiologic consequences of traumatic brain injury with special attention to the pathogenesis and sequalae of chronic traumatic encephalomalacia and interface astroglial scarring induced by concussive, impact and/or blast injury. The goal of this subaward is to study the chronic effects of a traumatic brain injury on small blood vessel function in the brain.

* NIH/NIGMS (RO1 GM123010 PI: Kalev Freeman)                                                

9/30/17-9/29/22 $193,000 (Annual direct costs)

Title: Impact of Trauma and its Factors on Vascular Endothelial Function

Role: Principal Investigator (40%FTE)

Brief description: This project will define functions of the endothelium in detecting and responding to injury and elucidate mechanisms that contribute to maladaptive vascular responses after severe trauma. We will determine the extent to which histone-induced endothelial cell injury alters vasodilatory, barrier and anticoagulation functions, and whether blocking this pathway protects endothelial functions in trauma. 

* NIH/NHLBI (UM1 HL120877 PIs: Kenneth Mann, Charles Esmon)          

Subcontract to the University of Vermont      (7.5%FTE)

9/30/13-6/30/19 $162,847 (Project 12 UVM Annual direct costs)

Title: Analysis and Characterization of Trauma-Induced Coagulopathy

Role: Co-investigator

Brief description: The Trans-Agency Research Consortium for Trauma-Induced Coagulopathy (TACTIC) grant’s global objective is to elucidate the mechanisms driving trauma induced coagulopathy.  Our work within this multi-investigator study focuses on the effects of trauma on endothelial function studied in animal models.

Grants - Completed Research Support

* NIH/NIGMS (K08 GM098795-01 PI: Kalev Freeman)

8/1/11-2/28/17 Annual direct costs $109,239

Title: Endothelial Ca2+ signals and vasodilatory function after traumatic brain injury

Role: Principal Investigator (80%FTE)

Brief description: The goal of this project is to understand fundamental mechanisms and functional consequences of endothelial vasodilatory signal changes that occur in a remote tissue bed – the mesenteric artery circulation – after a brain injury.  We will determine effects of trauma on endothelial calcium and vasodilatory signal in a rodent model of traumatic brain injury.

 

* Department of the Army (W911NF-10-1-0376 PI: Kenneth Mann)

3/1/10-8/31/16 Vermont annual direct costs $685,000

Title: Systems biology for biological responses to severe hemorrhage                       

Role: Co-investigator (5%FTE)

Brief description: We propose to use a multicenter approach to systematically examine and characterize the multiple aspects of the biology of coagulation and coagulopathy after traumatic and burn injury using existing databases, prospective collection and analysis of samples from patients, multiple animal models and in vitro systems. Data from these studies will be used to develop a comprehensive mathematical model of the human coagulation cascade and advanced analysis techniques will be used to interrogate the coagulation model to determine key mechanisms in the coagulation architecture.

 

UVM College of Medicine Internal Grant Program (PI: Kalev Freeman)

1/1/15-12/31/16 Annual direct costs $75,000

Title: Histone-induced endothelial calcium signals and sterile inflammation

Role: Principal Investigator

Brief description: The overall goal of this project is to test the effects of extracellular histones on endothelial calcium signals, inflammatory cytokines, and immune cell activation in a mouse model.

 

Luoxis Corporation (PI: Kalev Freeman)

8/1/14-7/31/16 Annual direct costs $85,151

Title: Measurement of oxidation-reduction potential in trauma and sepsis

Role: Principal Investigator

Brief description: The major goal of this project is to determine the diagnostic performance characteristics of oxidation-reduction potential measurements in patients with severe trauma or infections.

 

Haemonetics Corporation (PI: Kalev Freeman)        

11/1/14-10/31/16 Annual direct costs $41,000

Title: The Role of Factor XIa in Trauma-Induced Coagulopathy

Role: Principal Investigator

Brief description: This project seeks to evaluate the role of factor XIa in trauma-induced coagulopathy using viscoelastic measurements of whole blood clotting in trauma patients. 

 

UVMMG Research and Education Committee Grant (Co-PIs: Isabelle Desjardins, Kalev Freeman)

1/1/2013-12/31/2014 $75,000

Title: Building an expert system to evaluate suicide risk: replicating the expert judgement of experienced psychiatrists to optimize patient safety and resource utilization  

Role: Co-Principal Investigator

Brief description: The major goal of this project is to test the predictive validity of a screening algorithm developed by nationally recognized suicide experts for modeling critical thinking of experienced physicians.

 

UVM College of Medicine Surgical Research Award (PI: Kalev Freeman)  

7/1/09-6/30/11 Total $17,744

Title: Cardiac MRI to determine left ventricular function in a rodent model of traumatic brain injury

Role: Principal Investigator

Brief description: The goal of this project is to determine the acute effects of traumatic brain injury on cardiac function.

 

Masimo Corporation (PI: Kalev Freeman)    

4/1/11-3/31/14 Annual direct costs $100,000

Title: Evaluation of Masimo noninvasive carboxyhemoglobin testing in ED patients with suspected carbon monoxide poisoning.

Role: Principal Investigator

Brief description: The major goal of this project is to determine the accuracy of noninvasive carboxyhemoglobin testing in the emergency department setting.

 

* NIH (P20 RR16435/ P30 GM103498 PI: Rodney Parsons)

Center for Neuroscience Excellence, Pilot Project                                       

7/1/11-6/30/12 Annual direct costs $69,393

Title: Endothelial Ca2+ signals and blood brain barrier permeability following traumatic brain injury

Role: Principal Investigator (Pilot Project)

Brief description: The objective of this proposal is to understand the molecular basis and functional consequences of altered cerebral artery endothelial calcium (Ca2+) signaling and impaired neurovascular coupling after TBI.

 

UVM College of Medicine Surgical Research Award (PI: Kalev Freeman)  

7/1/11-6/30/13 Total $24,950

Title: A randomized controlled trial of cognitive therapy to enhance neural repair and improve outcomes following traumatic brain injury.

Role: Principal Investigator

Brief description: This pilot study evaluated the impact of cognitive therapy in human on outcomes in subjects after a traumatic brain injury.