Publications - Epilepsy, Cognition, and Development Group | College of Medicine

ECD Group Selected Publications

2019

Pujar S, Scott RC. Long-term outcomes after childhood convulsive status epilepticus. Curr Opin Pediatr. 2019 Sep 2.

Hinchcliff M, Mahoney JM. Towards a new classification of systemic sclerosis. Nature Rev Rheumatol. 2019 Aug;15(8):456-457. doi: 10.1038/s41584-019-0257-z.

Mahoney JM, Mills JD, Muhlebner A, Noebels J, Potschka H, Simonato M, Kobow K. 2017 WONOEP appraisal: Studying epilepsy as a network disease using systems biology approaches. Epilepsia. 2019 Jun;60(6):1045-1053. doi: 10.1111/epi.15216. Epub 2019 May 14.

Reilly C, Atkinson P, Memon A, Jones C, Dabydeen L, Das KB, Gillberg C, Neville BGR, Mahoney JM, Scott RC. Global development and adaptive behaviour in children with early-onset epilepsy: a population-based case-control study. Dev Med Child Neurol. 2019 Feb;61(2):145-151. doi: 10.1111/dmcn.13926.

Baram TZ, Donato F, Holmes GL. Construction and disruption of spatial memory networks during development. Learn Mem. 2019 Jun 17;26(7):206-218. doi: 10.1101/lm.049239.118. Print 2019 Jul.

Sánchez Fernández I, Goodkin HP, Scott RC. Pathophysiology of convulsive status epilepticus. Seizure. 2019 May;68:16-21. doi: 10.1016/j.seizure.2018.08.002.

Mouchati PR, Barry JM, Holmes GL. Functional brain connectivity in a rodent seizure model of autistic-like behavior. Epilepsy Behav. 2019 Jun;95:87-94. doi: 10.1016/j.yebeh.2019.03.046. Epub 2019 Apr 24.

Mott SH, Morse RP, Burroughs SA, Buckley AW, Farmer CA, Thurm AE, Swedo SE, Krag AL, Holmes GL. Functional brain connectivity in electrical status epilepticus in sleep. Epileptic Disord. 2019 Feb 1;21(1):55-64. doi: 10.1684/epd.2019.1027.

Valeeva G, Janackova S, Nasretdinov A, Rychkova V, Makarov R, Holmes GL, Khazipov R, Lenck-Santini PP. Emergence of Coordinated Activity in the Developing Entorhinal-Hippocampal Network. Cereb Cortex. 2019 Feb 1;29(2):906-920. doi: 10.1093/cercor/bhy309

Reilly C, Atkinson P, Memon A, Jones C, Dabydeen L, Helen Cross J, Das KB, Gillberg C, Neville BGR, Scott RC. Autism, ADHD and parent-reported behavioural difficulties in young children with epilepsy. Seizure. 2019 Oct;71:233-239. doi: 10.1016/j.seizure.2019.08.003.

2018

Hernan AE, Mahoney JM, Curry W, Richard G, Lucas MM, Massey A, Holmes GL, Scott RC. Environmental enrichment normalizes hippocampal timing coding in a malformed hippocampus. PLoS One. 2018 Feb 2;13(2):e0191488. doi: 10.1371/journal.pone.0191488. eCollection 2018.

Scott RC, Menendez de la Prida L, Mahoney JM, Kobow K, Sankar R, de Curtis M. WONOEP APPRAISAL: The many facets of epilepsy networks. Epilepsia. 2018 Aug;59(8):1475-1483. doi: 10.1111/epi.14503. Epub 2018 Jul 15.

Reilly C, Atkinson P, Memon A, Jones C, Dabydeen L, Das KB, Cross JH, Neville BGR, Gillberg C, Scott RC. Parenting stress and perceived stigma in mothers of young children with epilepsy: A case-control study. Epilepsy Behav. 2018 Dec;89:112-117. doi: 10.1016/j.yebeh.2018.10.016.

Reilly C, Atkinson P, Memon A, Jones C, Dabydeen L, Das KB, Gillberg C, Neville BGR, Scott RC. Symptoms of depression, anxiety, and stress in parents of young children with epilepsy: A case controlled population-based study. Epilepsy Behav. 2018 Mar;80:177-183. doi: 10.1016/j.yebeh.2017.12.020.

Pujar SS, Martinos MM, Cortina-Borja M, Chong WKK, De Haan M, Gillberg C, Neville BG, Scott RC, Chin RF; North London Epilepsy Research Network. Long-term prognosis after childhood convulsive status epilepticus: a prospective cohort study. Lancet Child Adolesc Health. 2018 Feb;2(2):103-111. doi: 10.1016/S2352-4642(17)30174-8.

2017

Hernan AE, Schevon CA, Worrell GA, Galanopoulou AS, Kahane P, de Curtis M, Ikeda A, Quilichini P, Williamson A, Garcia-Cairasco N, Scott RC, Timofeev I. Methodological standards and functional correlates of depth in vivo electrophysiological recordings in control rodents. A TASK1-WG3 report of the AES/ILAE Translational Task Force of the ILAE. Epilepsia. 2017 Nov;58 Suppl 4:28-39. doi: 10.1111/epi.13905

Barrows CM, McCabe MP, Chen H, Swann JW, Weston MC. PTEN Loss Increases the Connectivity of Fast Synaptic Motifs and Functional Connectivity in a Developing Hippocampal Network.J Neurosci. 2017 Sep 6;37(36):8595-8611. doi: 10.1523/JNEUROSCI.0878-17.2017. Epub 2017 Jul 27.

AE Hernan, GL Holmes. Antiepileptic drug treatment strategies in neonatal epilepsy. Progress in brain research 226, 179-193

Weston MC. The Role of PRRT2 in Synaptic Transmission May Not Be So Benign. Epilepsy Curr. 2017 May-Jun;17(3):165-166. doi: 10.5698/1535-7511.17.3.165.

Mahoney, JM. Imaging Techniques and Indications. Clin Podiatr Med Surg. 2017 Apr;34(2):115-128. doi: 10.1016/j.cpm.2016.10.014. Epub 2017 Jan 19. Review

2016

Massey AT, Lerner DK, Holmes GL, Scott RC, Hernan AE. ACTH Prevents Deficits in Fear Extinction Associated with Early Life Seizures. Frontiers in Neurology. 2016 April; 7(65). doi: 10.3389/fneur.2016.00065

Mahoney JM, Titiz AS, Hernan AE, Scott RC. Short-Range Temporal Interactions in Sleep; Hippocampal Spike Avalanches Support a Large Milieu of Sequential Activity Including Replay.PLoS One. 2016 Feb 11;11(2):e0147708. doi: 10.1371/journal.pone.0147708. eCollection 2016.

Bender AC, Luikart BW, Lenck-Santini PP. Cognitive Deficits Associated with Nav1.1 Alterations: Involvement of Neuronal Firing Dynamics and Oscillations. 2016 Mar 15;11(3):e0151538. doi: 10.1371/journal.pone.0151538. eCollection 2016.

Barry JM, Sakkaki S, Barriere SJ, Dube C, Lenck-Santini PP, Scott RC, Baram TZ, Holmes GL, Temporal coordination of hippocampal neurons reflects cognitive outcome post febrile status epilepticus. Ebiomedicine. In Press.

Barry JM, Spinella AJ, Page M, Jarvis P, Holmes GL. Spatial Cognition Following Early-Life Seizures: Performance Deficits are Dependent on Task Demands. Epilepsy and Behavior. In Press.

2015

Buckley AW, Scott R, Tyler A, Mahoney JM, Thurm A, Farmer C, Swedo S, Burroughs SA, Holmes GL. State-Dependent Differences in Functional Connectivity in Young Children With Autism Spectrum Disorder. EBioMedicine. 2015 Nov 5;2(12):1905-15. doi: 10.1016/j.ebiom.2015.11.004. eCollection 2015 Dec.

Lenck-Santini PP, Scott RC. Mechanisms Responsible for Cognitive Impairment in Epilepsy.Cold Spring Harb Perspect Med. 2015 Sep 3;5(10). pii: a022772. doi: 10.1101/cshperspect.a022772. Review.

Isaev D, Lushnikova I, Lunko O, Zapukhliak O, Maximyuk O, Romanov A, Skibo GG, Tian C, Holmes GL, Isaeva E. Contribution of protease-activated receptor 1 in status epilepticus-induced epileptogenesis. Neurobiol Dis. 2015 Jun;78:68-76. doi: 10.1016/j.nbd.2015.03.026. Epub 2015 Apr 2.

Holmes GL. Cognitive impairment in epilepsy: the role of network abnormalities.Epileptic Disord. 2015 Jun;17(2):101-16. doi: 10.1684/epd.2015.0739. Review.

Barry JM, Choy M, Dube C, Robbins A, Obenaus A, Lenck-Santini PP, Scott RC, Baram TZ, Holmes GL. T2 relaxation time post febrile status epilepticus predicts cognitive outcome.Exp Neurol. 2015 Jul;269:242-52. doi: 10.1016/j.expneurol.2015.04.015. Epub 2015 May 1.

Barry, JM. Axonal activity in vivo: technical considerations and implications for the exploration of neural circuits in freely moving animals. Fronteirs in Neuroscience. 06 May 2015. DOIL: http://dx.doi.org/10.3389/fnins.2015.00153

Flynn SP, Barriere S, Scott RC, Lenck-Santini PP, Holmes GL. Status Epilepticus Induced Spontaneous Dentate Gyrus Spikes: In Vivo Current Source Density Analysis. Plos One. 2015 July. DOI: 10.1371/journal.pone.0132630

Holmes GL, Tian C, Camp D, Hernan AE, Flynn S, Barry J. Alterations in Sociability and Functional Brain Connectivity Caused by Early-Life Seizures is Reversed by Bumetanide. Neurobiology of Disease. In press.

Jellett AP, Jenks K, Lucas M, Scott RC. Standard dose valproic acid does not cause additional cognitive impact in a rodent model of intractable epilepsy.Epilepsy Res. 2015 Feb;110:88-94. doi: 10.1016/j.eplepsyres.2014.11.005.

2014

Khan OI, Azevedo CJ, Hartshorn AL, Montanye JT, Gonzalez JC, Natola MA, Surgenor SD, Morse RP, Nordgren RE, Bujarski KA, Holmes GL, Jobst BC, Scott RC, Thadani VM. A comparison of continuous video-EEG monitoring and 30-minute EEG in an ICU. Epileptic Disord. 2014 Dec;16(4):439-48. doi: 10.1684/epd.2014.0715.

Holmes, GL. What is more harmful, seizures or epileptic EEG abnormalities? Is there any clinical data? Epileptic Disord. 2014 Oct;16 Suppl 1:12-22. doi: 10.1684/epd.2014.0686

Hernan AE, Alexander A, Jenks KR, Barry J, Lenck-Santini PP, Isaeva E, Holmes GL, Scott RC. Focal epileptiform activity in the prefrontal cortex is associated with long-term attention and sociability deficits. Neurobiol Dis. 2014 Mar;63:25-34. doi: 10.1016/j.nbd.2013.11.012. Epub 2013 Nov 19. PMID: 24269.

Hernan AE, Alexander A, Lenck-Santini PP, Scott RC, Holmes GL. Attention deficit associated with early life interictal spikes in a rat model is improved with ACTH.PLoS One. 2014 Feb 24;9(2):e89812. doi: 10.1371/journal.pone.0089812. eCollection 2014. PMID:24587054

Titiz AS, Mahoney JM, Testorf ME, Holmes GL, Scott RC. Cognitive impairment in temporal lobe epilepsy: Role of online and offline processing of single cell information. Hippocampus. 2014 May 2. doi: 10.1002/hipo.22297

Reilly C, Atkinson P, Das KB, Chin RF, Aylett SE, Burch V, Gillberg C, Scott RC, Neville BG. Neurobehavioral Comorbidities in Children With Active Epilepsy: A Population-Based Study. Pediatrics. 2014 May 26. pii: peds.2013-3787. PMID: 24864167

Duffy BA, Chun KP, Ma D, Lythgoe MF, Scott RC. Dexamethasone exacerbates cerebral edema and brain injury following lithium-pilocarpine induced status epilepticus. Neurobiol Dis. 2014 Mar;63:229-36. doi: 10.1016/j.nbd.2013.12.001. Epub 2013 Dec 12. PMID: 24333865

Burroughs SA, Morse RP, Mott SH, Holmes GL. Brain connectivity in West syndrome. Seizure. 2014 Apr 4. pii: S1059-1311(14)00098-3. doi: 10.1016/j.seizure.2014.03.016. PMID: 24794162

2013

Robbins AA, Fox SE, Holmes GL, Scott RC, Barry JM. Short duration waveforms recorded extracellularly from freely moving rats are representative of axonal activity. Front Neural Circuits. 2013 Nov 18;7:181. doi: 10.3389/fncir.2013.00181. eCollection 2013.

Richard GR, Titiz A, Tyler A, Holmes GL, Scott RC, Lenck-Santini PP. Speed modulation of hippocampal theta frequency correlates with spatial memory performance. Hippocampus. 2013 Jul 6. doi: 10.1002/hipo.22164.

Kleen JK, Scott RC, Holmes GL, Roberts DW, Rundle MM, Testorf M, Lenck-Santini PP, Jobst BC. Hippocampal interictal epileptiform activity disrupts cognition in humans. Neurology. 2013 Jul 2;81(1):18-24. doi: 10.1212/WNL.0b013e318297ee50.

Isaeva E, Isaev D, Holmes GL. Alteration of synaptic plasticity by neonatal seizures in rat somatosensory cortex. Epilepsy Res. 2013 Apr 25. doi:pii: S0920-1211(13)00096-X. 10.1016/j.eplepsyres.2013.03.011.

Bender AC, Natola H, Ndong C, Holmes GL, Scott RC, Lenck-Santini PP.Focal Scn1a knockdown induces cognitive impairment without seizures. Neurobiol Dis. 2013 Jun;54:297-307. doi: 10.1016/j.nbd.2012.12.021. Epub 2013 Jan 11.

Noam Y, Raol YH, Holmes GL. Searching for new targets for treatment of pediatric epilepsy. Epilepsy Behav. 2013 Apr;27(1):148-53. doi: 10.1016/j.yebeh.2012.12.030. Epub 2013 Feb 15.

Yoong M, Martinos MM, Chin RF, Clark CA, Scott RC. Hippocampal volume loss following childhood convulsive status epilepticus is not limited to prolonged febrile seizures. Epilepsia. 2013 Dec;54(12):2108-15. doi: 10.1111/epi.12426. Epub 2013 Oct 28. PMID: 24304434

Yoong M, Seunarine K, Martinos M, Chin RF, Clark CA, Scott RC. Prolonged febrile seizures cause reversible reductions in white matter integrity. Neuroimage Clin. 2013 Oct 24;3:515-21. doi: 10.1016/j.nicl.2013.10.010. eCollection 2013. PMID: 24273734

2012

Hernan AE, Holmes GL, Isaev D, Scott RC, Isaeva E. Altered short-term plasticity in the prefrontal cortex after early life seizures. Neurobiol Dis. 2012 Oct 12. pii: S0969-9961(12)00335-X. doi: 10.1016/j.nbd.2012.10.007.

Scott RC, Holmes GL.Before epilepsy unfolds: opening up the potassium door in neonatal seizures.Nat Med. 2012 Nov;18(11):1624-5. doi: 10.1038/nm.2987.

Tyler AL, Mahoney JM, Richard GR, Holmes GL, Lenck-Santini PP, Scott RC. Functional network changes in hippocampal CA1 after status epilepticus predict spatial memory deficits in rats. J Neurosci. 2012 Aug 15;32(33):11365-76. doi: 10.1523/JNeurosci.1516-12.2012.

Isaeva E, Hernan A, Isaev D, Holmes GL.Thrombin facilitates seizures through activation of persistent sodium current. Ann Neurol. 2012 Aug;72(2):192-8. doi: 10.1002/ana.23587.

Scott RC, Holmes GL. Febrile seizures and the wandering granule cell. Nat Med. 2012 Aug;18(8):1180-2. doi: 10.1038/nm.2898.

Kleen JK, Scott RC, Lenck-Santini PP, Holmes GL. Cognitive and Behavioral Co-Morbidities of Epilepsy. In: Noebels JL, Avoli M, Rogawski MA, Olsen RW, Delgado-Escueta AV, editors. Jasper's Basic Mechanisms of the Epilepsies [Internet]. 4th edition. Bethesda (MD): National Center for Biotechnology Information (US); 2012.

Bender AC, Morse RP, Scott RC, Holmes GL, Lenck-Santini PP. SCN1A mutations in Dravet syndrome: impact of interneuron dysfunction on neural networks and cognitive outcome. Epilepsy Behav. 2012 Mar;23(3):177-86. Epub 2012 Feb 16. Review.

2011

Stern JM, Labiner DM, Gilliam FG, Penovich PE, Onofrey M, Eagan CA, Holmes GL. More effective assessment of adverse effects and comorbidities in epilepsy: Results of a Phase II communication study. Epilepsy Behav. 2011 Oct 1.

Sahin M, Miller I, Holmes GL, Sheth RD. Pediatric epileptology. Epilepsy Behav. 2011 Sep;22(1):32-7.

Lai JS, Nowinski C, Victorson D, Bode R, Podrabsky T, McKinney N, Straube D, Holmes GL, McDonald CM, Henricson E, Abresch RT, Moy CS, Cella D. Quality-of-Life Measures in Children With Neurological Conditions: Pediatric Neuro-QOL. Neurorehabil Neural Repair. 2011 Jul 25.

Isaeva E, Lushnikova I, Savrasova A, Skibo G, Holmes GL, Isaev D. Effect of neuraminidase treatment on persistent epileptiform activity in the rat hippocampus. Pharmacol Rep.

Kulandaivel K, Holmes GL. Power spectral analysis in infants with seizures: relationship to development. Epilepsy Behav. 2011 Apr;20(4):700-5.

Isaev D, Zhao Q, Kleen JK, Lenck-Santini PP, Adstamongkonkul D, Isaeva E, Holmes GL. Neuroaminidase reduces interictal spikes in a rat temporal lobe epilepsy model. Epilepsia. 2011 Mar;52(3):e12-5. doi: 10.1111/j.1528-1167.2011.02988.x.

Meador KJ, Baker GA, Browning N, Cohen MJ, Clayton-Smith J, Kalayjian LA, Kanner A, Liporace JD, Pennell PB, Privitera M, Loring DW; NEAD Study Group. Foetal antiepileptic drug exposure and verbal versus non-verbal abilities at three years of age. Brain. 2011 Feb;134(Pt 2):396-404.

Yoong M, Martinos MM, Chin RF, Clark CA, Chong WK, Scott RC. The role for MRI in the follow up of children with convulsive status epilepticus. DMCN

Scott RC, Richard GR, Holmes GL, Lenck-Santini PP. Maturational dynamics of hippocampal place cells in rats. Hippocampus; 21(4), 347-353, 2011

Mohamed PB, Scott RC, Desai NA, Gutta P, Patil SG. Seizure outcome in infantile spasms; a retrospective study. Epilepsia; 52(4): 746-52, 2011.

Lucas M, Lenck-Santini PP, Holmes GL, Scott RC. Impaired cognition in rats with cortical dysplasia; additional impact of early life seizures. Brain; 134(6): 1684-1693, 2011

Chin RF, Cumberland PM, Pujar SS, Peckham C, Ross EM, Scott RC. Outcomes of childhood epilepsy at age 33 years: a population based birth cohort study. Epilepsia; 52(8): 1513-1521, 2011

Kleen JK, Sesque A, Wu EX, Miller FA, Hernan AE, Holmes GL, Scott RC. Early life seizures produce lasting alterations in the structure and function of the prefrontal cortex. Epilepsy and Behavior [epub ahead of print], 2011

Pujar SS, Nevile BG, Scott RC, Chin RF. Long term mortality following childhood convulsive status epilepticus. Brain, 134(10): 2819-2827, 2011

Holmes GL, Scott RC, Morse RP, Lenck-Santini PP. Maturation of EEG oscillations in children with sodium channel mutations, Brain and Development, 2011

Kleen JK, Wu, E, Holmes GL, Scott RC, Lenck-Santini PP. Enhanced oscillatory activity in the hippocampal-prefrontal network is related to short-term memory function after early-life seizures. J. Neuroscience, 2011

D'Argenzio L, Colonnelli MC, Harrison S, Jacques TS, Harkness W, Vargha-Khadem F, Scott RC, Cross JH. Cognitive outcome after extra-temporal epilepsy surgery in childhood. Epilepsia, 2011

2010

Isaeva E, Lushnikova I, Savrasova A, Skibo G, Holmes GL, Isaev D. Blockade of endogenous neuraminidase leads to an increase of neuronal excitability and activity-dependent synaptogenesis in the rat hippocampus. Eur J Neurosci. 2010 Dec;32(11):1889-96. doi: 10.1111/j.1460-9568.2010.07468.x.

Meador KJ, Baker GA, Browning N, Clayton-Smith J, Combs-Cantrell DT, Cohen M, Kalayjian LA, Kanner A, Liporace JD, Pennell PB, Privitera M, Loring DW; NEAD Study Group. Effects of breastfeeding in children of women taking antiepileptic drugs. Neurology. 2010 Nov 30;75(22):1954-60.

Jobst BC, Williamson PD, Thadani VM, Gilbert KL, Holmes GL, Morse RP, Darcey TM, Duhaime AC, Bujarski KA, Roberts DW. Intractable occipital lobe epilepsy: clinical characteristics and surgical treatment. Epilepsia. 2010 Nov;51(11):2334-7.

Pellock JM, Hrachovy R, Shinnar S, Baram TZ, Bettis D, Dlugos DJ, Gaillard WD, Gibson PA, Holmes GL, Nordl DR, O'Dell C, Shields WD, Trevathan E, Wheless JW. Infantile spasms: a U.S. consensus report. Epilepsia. 2010 Oct;51(10):2175-89. Review.

Khan OI, Zhao Q, Miller F, Holmes GL. Interictal spikes in developing rats cause long-standing cognitive deficits. Neurobiol Dis. 2010 Sep;39(3):362-71. Epub 2010 May 7.

Isaeva E, Isaev D, Savrasova A, Khazipov R, Holmes GL. Recurrent neonatal seizures result in long-term increases in neuronal network excitability in the rat neocortex. Eur J Neurosci. 2010 Apr;31(8):1446-55.

Kleen JK, Holmes GL. Taming TLR4 may ease seizures. Nat Med. 2010 Apr;16(4):369-70.

Pujar S., Calvert S., Cross J.H., Das K., Pitt M., Scott R.C. Demonstration of natural fluctuation in seizure frequency in young people with severe epilepsies using Statistical Process Control charts. Epilepsy Research, 91, 205-13, 2010

Choy M, Thomas D, Gadian DG, Scott RC, Lythgoe MF. Anatomical differences in cerebral blood flow response to pilocarpine induced status epilepticus may underlie hippocampal injury. Experimental Neurology, 225, 196-201, 2010

Kleen JK, Scott RC, Holmes GL, Lenck-Santini PP. Hippocampal interictal spikes disrupt cognition in rats. Annals of Neurology, 67(2), 250-257, 2010

Choy M, Lythgoe MF, Thomas D, Gadian DG, Scott RC. The timecourse of brain injury following pilocarpine induced status epilepticus in the rat. Epilepsy Research, 88(2-3), 221-230, 2010

Dunkley C, Kung J, Scott RC, Nicolaides P, Neville B, Aylett SE, Harkness W, Cross JH. Epilepsy surgery in children under 3 years. Epilepsy Research; 93(2-3):96-106, 2010.