Publications:

Dynamic regulation of subcellular mitochondrial position for localized metabolite levels.

Alshaabi H, Heininger M, Cunniff B. J Biochem. 2019 Jul 29.

Peroxiredoxins and Beyond; Redox Systems Regulating Lung Physiology and Disease.

Elko EA, Cunniff B, Seward DJ, Chia SB, Aboushousha R, van de Wetering C, van der Velden J, Manuel A, Shukla A, Heintz NH, Anathy V, van der Vliet A, Janssen-Heininger YMW. Antioxid Redox Signal. 2019

Observing the cell in its native state: Imaging subcellular dynamics in multicellular organisms.

Liu TL, Upadhyayula S, Milkie DE, Singh V, Wang K, Swinburne IA, Mosaliganti KR, Collins ZM, Hiscock TW, Shea J, Kohrman AQ, Medwig TN, Dambournet D, Forster R, Cunniff B, Ruan Y, Yashiro H, Scholpp S, Meyerowitz EM, Hockemeyer D, Drubin DG, Martin BL, Matus DQ, Koyama M, Megason SG, Kirchhausen T, Betzig E. Science. 2018

Miro1-mediated mitochondrial positioning shapes intracellular energy gradients required for cell migration.

Schuler MH, Lewandowska A, Caprio GD, Skillern W, Upadhyayula S, Kirchhausen T, Shaw JM, Cunniff B. Mol Biol Cell. 2017

AMPK activity regulates trafficking of mitochondria to the leading edge during cell migration and matrix invasion.

Cunniff B, McKenzie AJ, Heintz NH, Howe AK. Mol Biol Cell. 2016

Disabling Mitochondrial Peroxide Metabolism via Combinatorial Targeting of Peroxiredoxin 3 as an Effective Therapeutic Approach for Malignant Mesothelioma.

Cunniff B, Newick K, Nelson KJ, Wozniak AN, Beuschel S, Leavitt B, Bhave A, Butnor K, Koenig A, Chouchani ET, James AM, Haynes AC, Lowther WT, Murphy MP, Shukla A, Heintz NH. PLoS One. 2015

Peroxiredoxin 3 levels regulate a mitochondrial redox setpoint in malignant mesothelioma cells.

Cunniff B, Wozniak AN, Sweeney P, DeCosta K, Heintz NH. Redox Biol. 2014

Resolution of oxidative stress by thioredoxin reductase: Cysteine versus selenocysteine.

Cunniff B, Snider GW, Fredette N, Stumpff J, Hondal RJ, Heintz NH. Redox Biol. 2014

A direct and continuous assay for the determination of thioredoxin reductase activity in cell lysates.

Cunniff B, Snider GW, Fredette N, Hondal RJ, Heintz NH.  Anal Biochem. 2013

Mitochondrial-targeted nitroxides disrupt mitochondrial architecture and inhibit expression of peroxiredoxin 3 and FOXM1 in malignant mesothelioma cells.

Cunniff B, Benson K, Stumpff J, Newick K, Held P, Taatjes D, Joseph J, Kalyanaraman B, Heintz NH. J Cell Physiol. 2013

Peroxiredoxin 3 is a redox-dependent target of thiostrepton in malignant mesothelioma cells.

Newick K, Cunniff B, Preston K, Held P, Arbiser J, Pass H, Mossman B, Shukla A, Heintz N. PLoS One. 2012

Oxidative processing of latent Fas in the endoplasmic reticulum controls the strength of apoptosis.

Anathy V, Roberson E, Cunniff B, Nolin JD, Hoffman S, Spiess P, Guala AS, Lahue KG, Goldman D, Flemer S, van der Vliet A, Heintz NH, Budd RC, Tew KD, Janssen-Heininger YM. Mol Cell Biol. 2012

 

Molecular Biology of the Cell

Mitochondrial Redox Status

Graphs

Redox

Cellular Physiology Cover