ROS production by mitochondria: function or dysfunction?

Palma FR, Gantner BN, Sakiyama MJ, Kayzuka C, Shukla S, Lacchini R, Cunniff B, Bonini MG. Frontiers in Oncology 2023

WR1065 conjugated to thiol-PEG polymers as novel anticancer prodrugs: broad spectrum efficacy, synergism, and drug resistance reversal.

Walker DM, Lazarova TI, Riesinger SW, Poirier MC, Messier T, Cunniff B, Walker VE. Frontiers in Oncology 2023

Deletion of Miro1 in airway club cells potentiates allergic asthma phenotyoes.

Bruno S, Lamberty A, McCoy M, Mark Z, Aliyeva M, Butnor K, Poynter ME, Anathy V, Cunniff B. Frontiers in Allergy 2023

The subcellular architecture of mitochondria in driving cellular processes.

        Cunniff B, Jaiswal JK. Frontiers in Cell and Developmental Biology 2022

Local recruitment and feuling of the cellular powerplant to support cell invasion.

        Shannon N, Cunniff B. Developmental Cell 2022

Correction to: Lung organoids: advances in generation and 3D-visualization.

        Cunniff B, Druso JE, van der Velden JL. Histochemistry and Cell Biology 2021

Unique Cellular and Biochemical Features of Human Mitochondrial Peroxiredoxin 3 Establish the Molecular Basis for Its Specific Reaction with Thiostrepton.

Nelson KJ, Messier T, Milczarek S, Saaman A, Beuschel S, Gandhi U, Heintz N, Smalley TL, Lowther WT, Cunniff B. Antioxidants (Basel) 2021

Lung organoids: advances in generation and 3D-visualization.

Cunniff B, Druso JE, van der Velden JL. Histochemistry and Cell Biology 2021

Miro1-mediated mitochondrial positioning supports subcellular redox status

        Alshaabi H, Shannon N, Gravelle R, Milczarek S, Messier T, Cunniff B. Redox Biology 2020

Dynamic regulation of subcellular mitochondrial position for localized metabolite levels.

Alshaabi H, Heininger M, Cunniff B. J Biochem. 2019 Jul 29.

Peroxiredoxins and Beyond; Redox Systems Regulating Lung Physiology and Disease.

Elko EA, Cunniff B, Seward DJ, Chia SB, Aboushousha R, van de Wetering C, van der Velden J, Manuel A, Shukla A, Heintz NH, Anathy V, van der Vliet A, Janssen-Heininger YMW. Antioxid Redox Signal. 2019

Observing the cell in its native state: Imaging subcellular dynamics in multicellular organisms.

Liu TL, Upadhyayula S, Milkie DE, Singh V, Wang K, Swinburne IA, Mosaliganti KR, Collins ZM, Hiscock TW, Shea J, Kohrman AQ, Medwig TN, Dambournet D, Forster R, Cunniff B, Ruan Y, Yashiro H, Scholpp S, Meyerowitz EM, Hockemeyer D, Drubin DG, Martin BL, Matus DQ, Koyama M, Megason SG, Kirchhausen T, Betzig E. Science. 2018

Miro1-mediated mitochondrial positioning shapes intracellular energy gradients required for cell migration.

Schuler MH, Lewandowska A, Caprio GD, Skillern W, Upadhyayula S, Kirchhausen T, Shaw JM, Cunniff B. Mol Biol Cell. 2017

AMPK activity regulates trafficking of mitochondria to the leading edge during cell migration and matrix invasion.

Cunniff B, McKenzie AJ, Heintz NH, Howe AK. Mol Biol Cell. 2016

Disabling Mitochondrial Peroxide Metabolism via Combinatorial Targeting of Peroxiredoxin 3 as an Effective Therapeutic Approach for Malignant Mesothelioma.

Cunniff B, Newick K, Nelson KJ, Wozniak AN, Beuschel S, Leavitt B, Bhave A, Butnor K, Koenig A, Chouchani ET, James AM, Haynes AC, Lowther WT, Murphy MP, Shukla A, Heintz NH. PLoS One. 2015

Peroxiredoxin 3 levels regulate a mitochondrial redox setpoint in malignant mesothelioma cells.

Cunniff B, Wozniak AN, Sweeney P, DeCosta K, Heintz NH. Redox Biol. 2014

Resolution of oxidative stress by thioredoxin reductase: Cysteine versus selenocysteine.

Cunniff B, Snider GW, Fredette N, Stumpff J, Hondal RJ, Heintz NH. Redox Biol. 2014


Graphical AbstractBCMolecular Biology of the Cell

Mitochondrial Redox Status



Cellular Physiology Cover