From the Mann Laboratory
Our laboratory is interested in the superamolecular organization of protein-ligand complex assemblies and the functional expression of these assemblies. The principal physiologic model we examine is the process of blood coagulation. Studies extend from biophysical analyses of the assembly of the multi-protein complexes involved in the formation of blood coagulation catalysts to physiologic studies of congenital and acquired thrombotic and hemorragic diseases. These latter studies extend from computer models to human physiology in the expression and regulation of coagulation reactions. Studies of normal and pathologic human blood coagulation make use of a multifaceted array of analytical procedures to evaluate product precursor relationships during the coagulation process. Ultimately our research is aimed at developing better procedures for the diagnosis and therapeutic intervention in hemorragic and thrombotic diseases which are based upon mechanistically sound chemical descriptions of these processes.