John Salogiannis, Ph.D.

Assistant Professor

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Background


Dr. Salogiannis graduated with a B.S. in Neurobiology and Psychology from the University of Maryland in 2005. He received his Ph.D. in Neuroscience from Harvard University in 2013 and was a postdoctoral fellow at UCSD from 2014-2021. Dr. Salogiannis joined the faculty in the Department of Molecular Physiology and Biophysics as an Assistant Professor in 2021.  

Contact


Office:

HSRF118
802-656-2071

Lab:

HSRF123
802-656-5707

Lab Website

Lab Team


 

Research Description


The Salogiannis lab uses biochemistry, cutting-edge live cell microscopy and genetics in a variety of cell types (mammalian neurons, cancer cell lines, and the filamentous fungus Aspergillus nidulans) to investigate the molecular mechanisms underlying microtubule-based movement in health and disease.

Intracellular cargos (organelles, vesicles, macromolecules) are driven long distances along microtubules by molecular motors (16 cargo-carrying kinesins and one cytoplasmic dynein in interphase). Microtubule-based transport influences a range of functions critical for the survival, maintenance and growth of cells. The importance of this process is emphasized in neurological diseases, where a primary hallmark is defects in microtubule-based transport and distribution of cargos.

Our lab’s goal is to understand (1) the molecular mechanisms of how, when and where these cellular cargos move on microtubules (2) how the spatiotemporal distribution of cargos affects cellular and neuronal function and (3) how microtubule-based transport goes awry in neurological diseases such as Parkinson's disease.

Please see Lab Website for more information.

Highlighted Publications


1. Salogiannis, J.*, J.R. Christensen*, L.D. Songster, A. Aguilar-Maldonado, N. Shukla, and S.L. Reck-Peterson. PxdA interacts with the DipA phosphatase to regulate peroxisome hitchhiking on early endosomes. Mol Biol Cell (2021). 32(6): 492-503. *authors contributed equally to this work

2. Deniston, C.D.*, J. Salogiannis*, S. Mathea*, D.M. Snead, I. Lahiri, M. Matyszewski, O. Donosa, R. Watanabe, J. Böhning, A.K. Shiau, S. Knapp, E. Villa, S.L. Reck-Peterson, and A.E. Leschziner. Structure of LRRK2 in Parkinson’s disease and model for microtubule interaction.  Nature (2020). 588: 344-349. *authors contributed equally to this work

3. Salogiannis, J. and S.L. Reck-Peterson. Hitchhiking: A non-canonical mode of microtubule- based transport. Trends in Cell Biol (2017). 27(2): 141-150.

4. Salogiannis, J., M. J. Egan, and S.L. Reck-Peterson. Peroxisomes move by hitchhiking on early endosomes using the novel linker protein PxdA. J Cell Biol (2016). 212(3):289-296.

 

Complete list of J. Salogiannis publications.