Glass Lab Publications


For latest updates on the lab’s recent papers and citation information, please see the link to My NCBI or the comprehensive Google Scholar Citations.


2021 Parikh SJ, Kamat S, Phillips M, Boyson SP, Yarbrough T, Davie D, Zhang Q, Glass KC, Shah MB. Insights into the Genetic Variations of Human Cytochrome P450 2C9: Structural Analysis, Characterization and Comparison.  Int J Mol Sci. 2021 Sep 22;22(19). doi: 10.3390/ijms221910206. PMID: 34638547


2021 Evans CM, Phillips M, Malone KL, Tonelli M, Cornilescu G, Cornilescu C, Holton SJ, Gorjánácz M, Wang L, Carlson S, Gay JC, Nix JC, Demeler B, Markley JL, Glass KCCoordination of Di-Acetylated Histone Ligands by the ATAD2 Bromodomain. Int J Mol Sci. 2021 Aug 24;22(17). doi: 10.3390/ijms22179128.  PMID: 34502039


2021 Boyson SP, Gao C, Quinn K, Boyd J, Paculova H, Frietze S, Glass KC. Functional Roles of Bromodomain Proteins in Cancer. Cancers (Basel). 2021 Jul 19;13(14). doi: 10.3390/cancers13143606. Review. PMID: 34298819


2020 Parikh SJ, Evans CM, Obi JO, Zhang Q, Maekawa K, Glass KC, Shah MB. Structure of Cytochrome P450 2C9*2 in Complex with Losartan: Insights into the Effect of Genetic Polymorphism. Mol Pharmacol. 2020 Nov;98(5):529-539. doi: 10.1124/molpharm.120.000042. Epub 2020 Sep 16. PMID: 32938720; 


2020 Lloyd JT, McLaughlin K, Lubula MY, Gay JC, Dest A, Gao C, Phillips M, Tonelli M, Cornilescu G, Marunde MR, Evans CM, Boyson SP, Carlson S, Keogh MC, Markley JL, Frietze S, Glass KC. Structural Insights into the Recognition of Mono- and Diacetylated Histones by the ATAD2B Bromodomain. J Med Chem. 2020 Nov 12;63(21):12799-12813. doi: 10.1021/acs.jmedchem.0c01178. Epub 2020 Oct 21. PMID: 33084328.


2020 Obi JO, Lubula MY, Cornilescu G, Henrickson A, McGuire K, Evans CM, Phillips M, Boyson SP, Demeler B, Markley JL, Glass KCThe BRPF1 bromodomain is a molecular reader of di-acetyllysine. Curr Res Struct Biol. 2020;2:104-115. doi: 10.1016/j.crstbi.2020.05.001. Epub 2020 May 12. PMID: 33554132


2019 Gay JC, Eckenroth BE, Evans CM, Langini C, Carlson S, Lloyd JT, Caflisch A, Glass KCDisulfide bridge formation influences ligand recognition by the ATAD2 bromodomain. Proteins. 2019 Feb;87(2):157-167. doi: 10.1002/prot.25636. Epub 2018 Dec 27. PMID: 30520161.


2018 Lloyd JT, Glass KCBiological function and histone recognition of family IV bromodomain-containing proteinsJ Cell Physiol, 233(3):1877-1886, 2018. PMID: 28500727

2016 Hassan HE, Keita JA, Narayan L, Brady SM, Frederick R, Carlson S, Glass KC, Natesan S, Buttolph T, Fandy TE. The combination of dimethoxycurcumin with DNA methylation inhibitor enhances gene re-expression of promoter-methylated genes and antagonizes their cytotoxic effectEpigenetics, 1-10, 2016. PMID: 27588609

2016 Kim S, Natesan S, Cornilescu G, Carlson S, Tonelli M, McClurg UL, Binda O, Robson CN, Markley JL, Balaz S, Glass KC. Mechanism of Histone H3K4me3 Recognition by the Plant Homeodomain of Inhibitor of Growth 3J Biol Chem, 291(35):18326-41, 2016. PMID: 27281824

2015 Hassan HE, Carlson S, Abdallah I, Buttolph T, Glass KC, Fandy TE. Curcumin and dimethoxycurcumin induced epigenetic changes in leukemia cellsPham Research. 32(3):863-75, 2015. PMID: 25186441

2014 Lubula MY, Eckenroth BE, Carlson S, Poplawski A, Chruszcz M, Glass KC. Structural insights into recognition of acetylated histone ligands by the BRPF1 bromodomain. FEBS Letters, 588(21):3844-54, 2014. PMID: 25281266

2014 Lubula M, Poplawski A, Glass KC. Crystallization and preliminary X-ray diffraction analysis of the BRPF1 bromodomain in complex with its H2AK5ac and H4K12ac histone-peptide ligandsActa Crystallogr F Struct Biol Commun. 70(Pt 10):1389-93, 2014. PMID: 25286946

2014 Carlson S, Glass KCThe MOZ histone acetyltransferase in epigenetic signaling and diseaseJ Cel. Physiol. 229(11):1571-4, 2014. PMID: 24633655

2014 Poplawski A, Hu K, Lee W, Natesan S, Peng D, Carlson S, Shi X, Balaz S, Markley JL, Glass KCMolecular insights into the recognition of N-terminal histone modifications by the BRPF1 bromodomainJ Mol Biol. 426: 1661-1676, 2014. PMID: 24333487

2013 Lalonde ME, Glass KC, Avakumov N, Joncas FH, Saksouk N, Paquet E, Holliday M, Tan S, Yang XJ, Kutateladze TG, Côté J. Exchange of associated factors directs a switch in HBO1 acetyltransferase histone tail specificityGenes Dev. 27(18):2009-24, 2013. PMID: 24065767

2013 Lee W, Hu K, Toneli M, Bahrami A, Neuhardt E, Glass KC, Markley JL. Fast automated protein NMR data collection and assignment by ADAPT-NMR on Bruker spectrometersJ Magn Reson. 236:83-8, 2013. PMID: 24091140

2012 Yuan CC, Matthews AG, Jin Y, Chen CF, Chapman BA, Ohsumi TK, Glass KC, Kutateladze TG, Borowsky ML, Struhl K, Oettinger MA. Histone H3R2 symmetric dimethylation and histone H3K4 trimethylation are tightly correlated in eukaryotic genomesCell Reports. 1(2):83-90, 2012. PMID: 22720264

2012 Avvakumov N, Lalonde ME, Saksouk N, Paquet E, Glass KC, Landry AJ, Doyon Y, Cayrou C, Robitaille GA, Richard DE, Yang XJ, Kutateladze TG, Côté J. Conserved molecular interactions within the HBO1 acetyltransferase complexes regulate cell proliferationMol Cell Biol. 32(3):689-703, 2012. PMID: 22144582

2010 Hom, RA, Chang, PY, Roy, S*, Musselman, CA*, Glass, KC*, Selezneva, AI, Gozani, O, Ismagilov, RF, Cleary, MI, Kutateladze, TG. Molecular mechanism of MLL PHD3 and RNA recognition by the Cyp33 RRM domainJ Mol Biol. Jul 9;400(2):145-54, 2010. PMID: 20460131

2010 Roy S, Musselman CA, Kachirskaia I, Hayashi R, Glass KC, Nix JC, Gozani O, Appella E, Kutateladze TG. Structural insight into p53 recognition by the 53BP1 tandem Tudor domainJ Mol Biol. 14;398(4):489-96, 2010. PMID: 20307547

2009 Champagne KS, Kutateladze TG. Structural insight into histone recognition by the ING PHD fingersCurrent Drug Targets. 10:432-41, 2009. PMID: 19442115

2009 Hung T*, Binda O*, Champagne KS*, Kuo AJ, Johnson K, Chang HY, Simon MD, Kutateladze TG, Gozani O. ING4 mediates crosstalk between histone H3 K4 trimethylation and H3 acetylation to attenuate cellular transformationMol Cell. 33:248-256, 2009. PMID: 19187765

2009 Saksouk N, Avvakumov N*, Champagne KS*, Hung T*, Doyon Y, Cayrou C, Paquet E, Ulla M, Landry AJ, Côté V, Yang XJ, Gozani O, Kutateladze TG, Côté J. HBO1 HAT complexes target chromatin throughout gene coding regions via multiple PHD finger interactions with histone H3 tailMol Cell. 33:257-265, 2009. PMID: 19187766

2008 Champagne KS, Saksouk N, Peña PV, Johnson K, Ullah M, Yang XJ, Côté J, Kutateladze TG. The crystal structure of the ING5 PHD finger in complex with an H3K4me3 histone peptideProteins. 72: 1371-6, 2008. PMID: 18623064

2008 Peña PV, Hom RA, Hung T, Lin H, Kuo AJ, Wong RP, Subach OM, Champagne KS, Zhao R, Verkhusha VV, Li G, Gozani O, Kutateladze TG. Histone H3K4me3 binding is required for the DNA repair and apoptotic activities of ING1 tumor suppressorJ Mol Biol. 380: 303-12, 2008. PMID: 18533182

2007 Matthews AG, Kuo AJ, Ramón-Maiques S, Han S, Champagne KS, Ivanov D, Gallardo M, Carney D, Cheung P, Ciccone DN, Walter KL, Utz PJ, Shi Y, Kutateladze TG, Yang W, Gozani O, Oettinger MA. RAG2 PHD finger couples histone H3 lysine 4 trimethylation with V(D)J recombinationNature. 450 (7172): 1106-10, 2007. PMID: 18033247

2006 Champagne KS, Piscitelli E, Francklyn CS. Substrate recognition by the hetero-octameric ATP phosphoribosyltransferase from Lactococcus lactisBiochemistry. 45:14933-43, 2006. PMID:  17154531

2005 Champagne KS, Sissler M, Larrabee Y, Doublié S, Francklyn CS. Activation of the hetero-octameric ATP phosphoribosyl transferase through subunit interface rearrangement by a tRNA synthetase paralogJ Biol Chem. 280: 34096-34104, 2005. PMID: 16051603

2002 Bovee ML, Champagne KS, Demeler B, Francklyn CS. The quaternary structure of the HisZ-HisG N-1-(5'-phosphoribosyl)-ATP transferase from Lactococcus lactisBiochemistry.  41:11838-11846, 2002. PMID: 12269828

*These authors contributed equally to the work.

** Please note name change in 2009 from Champagne KS to Glass KC.



Dr. Karen Glass


Phone: (802)656-5760
Office Location:
Given, Rm C205A









1. Cloud J. (2010).  Why Your DNA Isn't Your Destiny.  Time Magazine 172.

2. Aebersold R, Agar JN, Amster IJ, Baker MS, Bertozzi CR, Boja ES, et al. (2018).  How many human proteoforms are there?  Nat Chem Biol 14, 206-214.

3. Filippakopoulos P, Picaud S, Mangos M, Keates T, Lambert JP, Barsyte-Lovejoy D, et al. (2012).  Histone recognition and large-scale structural analysis of the human bromodomain family.  Cell 149, 214-231.

4. Lubula MY, Eckenroth BE, Carlson S, Poplawski A, Chruszcz M, Glass KC.  (2014).  Structural insighes into recognition of acetylated histone ligands by the BRPF1 bromodomain.  FEBS Lett.  

5. Poplawski A, Hu K, Lee W, Natesan S, Peng D, Carson S, Shi X, Balaz S, Markley JL, Glass KC.  (2014). Molecular insights into the recognition of N-terminal histone modifications by the BRPF1 bromodomain.  J Mol Biol  426, 1661-1676. 

6. Kitabayaski I, Aikawa Y, Yokoyamma A, Hosoda F, Nagi M, Kakazu N, et al. (2001).  Fusion of MOZ and p300 histone acetyltransferases in acute monotytic leukemia with a t(8;22)(p1;q13) chromosome translocation.  Leukemia 15, 89-94

7. Carpapeti M, Agular RC, Goldman JM, Cross NC.  (1998). A novel fusion between MOZ and the nuclear receptor coactivator TIF2 in acute myeloid leukemia.  Blood  91, 3127-3133.

8. Champagne KS, Saksouk N, Pena PV, Johnson K, Ullah M, Yang X, et al.  (2008).  The crystal structure of the ING5 PHD finger in complex with an H3K4me3 histone peptide.  Proteins  72, 1371-1376.

9. Lalonde ME, Avvakumov N, Glass KC, Joncas FH, Saksouk N, Holliday M, et al. (2013).  Exchange of associated factors directs a switch in HBO1 acetyletransferase histone tail specificity.  Genes Dev  27, 2009-2024.

10. Carlson S, Glass KC.  (2014).  The MOZ Histone Acetyltransferase in Epigenetic Signaling and Disease.  J Cell Physiol.

11.  Filippakopoulos P, KnappS.  (2014). Targeting bromodomains:  epigenetic readers of lysine acetylation.  Nat Rev Drug Discov 13, 337-356.