Greenblatt Research

Area of interest

Classify genetic variants in cancer susceptibility genes 

Refining methods to classify all genetic variants through membership in the ClinGen Sequence Variant Interpretation (SVI) Working Group.  The SVI is improving criteria for interpreting and integrating multiple lines of evidence (epidemiology, statistics, tumor pathology, evolution, structure, and function, computational algorithms). 

Chair of the InSiGHT-ClinGen Polyposis-Colorectal Cancer Variant Curation Expert Panel, which is assessing variants in the APC, MUTYH, SMAD4, BMPR1, STK11, POLD1, and POLE genes.  

Position Description

 

Title: Post Doctoral Associate

Location:  Department of Medicine (Hematology/Oncology Unit), University of Vermont Larner College of Medicine

Date Available:  October 1, 2021

 

Responsibilities: The candidate will perform the duties of this position under the supervision of Dr. Marc Greenblatt. The University of Vermont, Department of Medicine, is seeking a Postdoctoral Associate who will support ongoing efforts, under the direction of Marc S. Greenblatt, M.D., to expand the curation of genetic variants in cancer susceptibility genes for the newly formed InSiGHT-ClinGen Polyposis/Colon Cancer Variant Curation Expert Panel (VCEP).  The successful candidate will join a team of experts from the International Society for Gastrointestinal Hereditary Tumors (InSiGHT, an international multidisciplinary, scientific organization) and the Clinical Genome Resource, known as ClinGen, a multi-institutional effort funded by the NIH to build a central resource that defines the clinical relevance of genes and variants for use in precision medicine and research.

The Post Doctoral Biocurator will support ClinGen curation activities by assisting with literature curation, data collection, and analysis to assess the relationships among genes, variants, and clinical diagnoses associated with colon polyposis and cancer.  Successful job performance will require learning and implementing the curation framework and protocols developed by ClinGen.  

The ideal candidate will be well versed in the scientific principles of genetics, genomic medicine, carcinogenesis, and cancer biology.  The candidate must have the ability to 1) comprehend and apply complex curation processes in analysis of genomic variation and cancer biology; 2)  read and critically evaluate the research literature to assess the state of knowledge about a genetic relationship, and to evaluate the strength of evidence provided; 3) work independently while maintaining strong communication with local and external collaborators.  

The position requires basic application of computational tools and information technology to gather, analyze and visualize data in biology and biomedical research, and basic Excel and database usage. Knowledge of online genetic databases such as ClinVar, OMIM, and LOVD and familiarity with basic excel and database usage is expected.

 

Approximately 75% of activities of the Postdoctoral Associate- Biocurator will involve curation and other scientific activities.

Approximately 25% will involve assisting in coordination of VCEP activities. The Post Doctoral Associate-Biocurator will participate in local meetings with the PI and conference calls with national and international experts.

 

The candidate will develop a focused area of research as a basis for development of an independent career through support of interdisciplinary research projects that require curation of genomic knowledge, bioinformatics and statistical methods, and interaction with researchers studying colorectal cancer genetics. Additional areas of focus will include grant and manuscript writing, presentation skills, and budgeting.

 

Qualifications:  

 

Ph.D. in genetics, molecular biology, biochemistry, bioinformatics, or a related field. 

Administrative experience required, sufficient to coordinate activities of an international research team.  

 

EOE/AA Statement:  The University of Vermont is an Equal Opportunity/Affirmative Action Employer. Applications from women, veterans, individuals with disabilities and people from diverse racial, ethnic, and cultural backgrounds are encouraged.

 

Application Procedure:  Send letter of application and curriculum vitae to Dr. Marc Greenblatt at marc.greenblatt@uvmhealth.org  

 

Application Deadline: Review of applications will begin immediately. Applications will be accepted until the position is filled.