Recent Publications

Ghule PN, Boyd JR, Kabala F, Fritz AJ, Bouffard NA, Gao C, Bright K, Macfarlane J, Seward DJ, Pegoraro G, Misteli T, Lian JB, Frietze S, Stein JL, van Wijnen AJ, Stein GS. Spatiotemporal higher-order chromatin landscape of human histone gene clusters at histone locus bodies during the cell cycle in breast cancer progression. Gene. 2023 Apr 23;872:147441. doi: 10.1016/j.gene.2023.147441. Epub ahead of print. PMID: 37094694.

Gordon JAR, Evans MF, Ghule PN, Lee K, Vacek P, Sprague BL, Weaver DL, Stein GS, Stein JL. Identification of molecularly unique tumor-associated mesenchymal stromal cells in breast cancer patients. PLoS One. 2023 Mar 20;18(3):e0282473. doi: 10.1371/journal.pone.0282473. PMID: 36940196; PMCID: PMC10027225. 

Fritz AJ, Ghule PN, Toor R, Dillac L, Perelman J, Boyd J, Lian JB, Gordon JAR, Frietze S, Van Wijnen A, Stein JL, Stein GS. Spatiotemporal Epigenetic Control of the Histone Gene Chromatin Landscape during the Cell Cycle. Crit Rev Eukaryot Gene Expr. 2023;33(3):85-97. doi: 10.1615/CritRevEukaryotGeneExpr.2022046190. PMID: 37017672.

Dashti P, van de Peppel J, Thaler R, Paradise CR, Stein GS, Montecino MA, van Leeuwen JPTM, van der Eerden BJ, Dudakovic A, van Wijnen AJ. The lysine methyltransferases SET and MYND domain containing 2 (Smyd2) and Enhancer of Zeste 2 (Ezh2) co-regulate osteoblast proliferation and mineralization. Gene. 2023 Jan 30;851:146928. doi: 10.1016/j.gene.2022.146928. Epub 2022 Sep 30. PMID: 36191822.

Messier TL, Boyd JR, Gordon JAR, Tye CE, Page NA, Toor RH, Zaidi SK, Komm BS, Frietze S, Stein JL, Lian JB, Stein GS. Epigenetic and transcriptome responsiveness to ER modulation by tissue selective estrogen complexes in breast epithelial and breast cancer cells. PLoS One. 2022 Jul 21;17(7):e0271725. doi: 10.1371/journal.pone.0271725. PMID: 35862394; PMCID: PMC9302754.

Nachmanson D, Officer A, Mori H, Gordon J, Evans MF, Steward J, Yao H, O'Keefe T, Hasteh F, Stein GS, Jepsen K, Weaver DL, Hirst GL, Sprague BL, Esserman LJ, Borowsky AD, Stein JL, Harismendy O. The breast pre-cancer atlas illustrates the molecular and micro-environmental diversity of ductal carcinoma in situ. NPJ Breast Cancer. 2022 Jan 13;8(1):6. doi: 10.1038/s41523-021-00365-y. PMID: 35027560; PMCID: PMC8758681.

Fertal SA, Zaidi SK, Stein JL, Stein GS, Heath JL. CXCR4 Mediates Enhanced Cell Migration in CALM-AF10 Leukemia. Front Oncol. 2022 Jan 5;11:708915. doi: 10.3389/fonc.2021.708915. PMID: 35070954; PMCID: PMC8767107.

Bighetti-Trevisan RL, Almeida LO, Castro-Raucci LMS, Gordon JAR, Tye CE, Stein GS, Lian JB, Stein JL, Rosa AL, Beloti MM. Titanium with nanotopography attenuates the osteoclast-induced disruption of osteoblast differentiation by regulating histone methylation. Mater Sci Eng C Mater Biol Appl. 2021 Nov 13:112548. doi: 10.1016/j.msec.2021.112548. Epub ahead of print. PMID: 35012895.

Che X, Park NR, Jin X, Jung YK, Han MS, Park CY, Chun JS, Kim SG, Jin J, Kim HJ, Lian JB, Stein JL, Stein GS, Choi JY. Hypoxia-inducible factor 2α is a novel inhibitor of chondrocyte maturation. J Cell Physiol. 2021 Oct;236(10):6963-6973. doi: 10.1002/jcp.30356. Epub 2021 Mar 21. PMID: 33748969; PMCID: PMC8662706.

Nirala NK, Li Q, Ghule PN, Chen HJ, Li R, Zhu LJ, Wang R, Rice NP, Mao J, Stein JL, Stein GS, van Wijnen AJ, Ip YT. Hinfp is a guardian of the somatic genome by repressing transposable elements. Proc Natl Acad Sci U S A. 2021 Oct 12;118(41):e2100839118. doi: 10.1073/pnas.2100839118. PMID: 34620709; PMCID: PMC8521681.

Freitas GP, Lopes HB, Souza ATP, Gomes MPO, Quiles GK, Gordon J, Tye C, Stein JL, Stein GS, Lian JB, Beloti MM, Rosa AL. Mesenchymal stem cells overexpressing BMP-9 by CRISPR-Cas9 present high in vitro osteogenic potential and enhance in vivo bone formation. Gene Ther. 2021 Dec;28(12):748-759. doi: 10.1038/s41434-021-00248-8. Epub 2021 Mar 8. PMID: 33686254; PMCID: PMC8423866.

Rose JT, Moskovitz E, Boyd JR, Gordon JA, Bouffard NA, Fritz AJ, Illendula A, Bushweller JH, Lian JB, Stein JL, Zaidi SK, Stein GS. Inhibition of the RUNX1-CBFβ transcription factor complex compromises mammary epithelial cell identity: a phenotype potentially stabilized by mitotic gene bookmarking. Oncotarget. 2020 Jun 30;11(26):2512-2530. doi: 10.18632/oncotarget.27637. PMID: 32655837; PMCID: PMC7335667.

Zhou Y, Gerrard DL, Wang J, Li T, Yang Y, Fritz AJ, Rajendran M, Fu X, Stein G, Schiff R, Lin S, Frietze S, Jin VX. Temporal dynamic reorganization of 3D chromatin architecture in hormone-induced breast cancer and endocrine resistance. Nat Commun. 2019 Apr 3;10(1):1522. doi: 10.1038/s41467-019-09320-9. Erratum in: Nat Commun. 2020 Apr 20;11(1):1967. PMID: 30944316; PMCID: PMC6447566.

Rojas A, Sepulveda H, Henriquez B, Aguilar R, Opazo T, Nardocci G, Bustos F, Lian JB, Stein JL, Stein GS, van Zundert B, van Wijnen AJ, Allende ML, Montecino M. Mll-COMPASS complexes mediate H3K4me3 enrichment and transcription of the osteoblast master gene Runx2/p57 in osteoblasts. J Cell Physiol. 2019 May;234(5):6244-6253. doi: 10.1002/jcp.27355. Epub 2018 Sep 7. PMID: 30256410; PMCID: PMC7261149.

Hong D, Fritz AJ, Finstad KH, Fitzgerald MP, Weinheimer A, Viens AL, Ramsey J, Stein JL, Lian JB, Stein GS. Suppression of Breast Cancer Stem Cells and Tumor Growth by the RUNX1 Transcription Factor. Mol Cancer Res. 2018 Dec;16(12):1952-1964. doi: 10.1158/1541-7786.MCR-18-0135. Epub 2018 Aug 6. PMID: 30082484; PMCID: PMC6289193.

Zaidi SK, Nickerson JA, Imbalzano AN, Lian JB, Stein JL, Stein GS. Mitotic Gene Bookmarking: An Epigenetic Program to Maintain Normal and Cancer Phenotypes. Mol Cancer Res. 2018 Nov;16(11):1617-1624. doi: 10.1158/1541-7786.MCR-18-0415. Epub 2018 Jul 12. PMID: 30002192; PMCID: PMC6214712.

Tracy KM, Tye CE, Ghule PN, Malaby HLH, Stumpff J, Stein JL, Stein GS, Lian JB. Mitotically-Associated lncRNA (MANCR) Affects Genomic Stability and Cell Division in Aggressive Breast Cancer. Mol Cancer Res. 2018 Apr;16(4):587-598. doi: 10.1158/1541-7786.MCR-17-0548. Epub 2018 Jan 29. PMID: 29378907; PMCID: PMC5882506.