Key Publications

  1. Francklyn, C. & Schimmel, P. (1989) Aminoacylation of RNA Minihelices with Alanine. Nature 337: 478-481.

  2. Francklyn, C., Shi, J. P., & Schimmel, P. (1992) Overlapping Nucleotide Determinants for Specific Aminoacylation of RNA Microhelices with Three Different Amino Acids. Science. 255: 1121-1125.8990.

  3. Dock-Bregeon, A.-C., Sankaranarayan R., Romby, P., Caillet, J., Springer, M., Rees, B., Francklyn, C. S., Ehresmann, C., Moras, D. (2000) Transfer RNA mediated editing in the Class II Threonyl-tRNA Synthetase: Mirror Image of a Class I Editing Mechanism. Cell: 103: 877-884.

  4. Ruan, B., Bovee, M.L., Sacher, M., Stathopoulos, C., Poralla, K., Francklyn, C.S., & Soll, D. (2005) A unique hydrophobic cluster near the active site contributes to differences of borrelidin inhibition among threonyl-tRNA synthetases.  J. Biol. Chem. 280: 571-577.

  5. Guth, E. & Francklyn, C.S. (2007) Kinetic Discrimination proofreading of tRNA identity by the conserved motif 2 loop of a class II aminoacyl-tRNA Synthetase. Molecular Cell 25:531-542.

  6. Minajigi A, Francklyn CS. (2008) RNA-assisted catalysis in a protein enzyme: the 2´-hydroxyl of tRNA (Thr) promotes aminoacylation by threonyl-tRNA synthetase. Proc. Natl. Acad. Sci. U. S. A. 2008 Nov 18; 105 (46): 17748-53. PMID: 18997014.

  7. Minajigi A, Francklyn CS. (2010) Aminoacyl transfer rate dictates choice of editing pathway in threonyl-tRNA synthetase. J. Biol. Chem.  Jul 30; 285(31): 23810-7.  PMID: 20504770.

  8. Puffenberger EG, Jinks RN, Sougnez C, Cibulskis K, Willert RA, Achilly NP, Cassidy RP, Fiorentini CJ, Heiken KF, Lawrence JJ, Mahoney MH, Miller CJ, Nair DT, Politi KA, Worcester KN, Setton RA, Dipiazza R, Sherman EA, Eastman JT, Francklyn C, Robey-Bond S, Rider NL, Gabriel S, Morton DH, Strauss KA (2012) Genetic mapping and exome sequencing identify variants associated with five novel diseases. PLoS One. 2012;7(1):e28936. Epub 2012 Jan 17. PMID: 22279524.

  9. Williams TF, Mirando AC, Wilkinson, B, Francklyn C, Lounsbury KM. Secreted Threonyl-tRNA Synthetase Stimulates Endothelial Cell Migration and Angiogenesis. (2013) Scientific Reports. 3: 1317 DOI: 10.1.1038/srep01317.

  10. Li L, Francklyn, C., Carter CW Jr. (2013) Aminoacylating Urzymes challenge the RNA world hypothesis. J. Biol. Chem. 288(37) 26856-63. PMID:23867455.

All Publications

Dr. Christopher Francklyn