Publications

 

For latest updates on the lab’s recent papers and citation information, please see the link to My NCBI (link) or the comprehensive Google Scholar Citations Page (link)

Evans CM, Phillips M, Malone KL, Tonelli M, Cornilescu G, Cornilescu C, Holton SJ, Gorjanacz M, Wang L, Carlson S, Gay JC, Nix JC, Demeler B, Markley JL, and Glass KC. (2021). Coordination of di-acetylated histone ligands by the ATAD2 bromodomain. Int J Mol Sci, Aug 24th, 2021. DOI: 10/3390/ijms22179128. PMID:34502039

Boyson SP, Gao C, Quinn K, Boyd J, Paculova H, Frietze S, and Glass KC. (2021). Functional Roles of Bromodomain Proteins in Cancer. Cancers (Basel), Jul 19:13(14):3606. DOI: 10.3390/cancers13143606. PMID: 34298819

Parikh SJ, Evans CM, Obi JO, Zhang Q, Maekawa K, Glass KC and Shah MB. (2020) Structure of cytochrome P450 2C9*2 in complex with losartan: Insights into the effect of genetic polymorphism. Mol Pharmacol., Nov;98(5):529-539. DOI: https://doi.org/10.1124/molpharm.120.000042. PMID:32938720

Lloyd JT, McLaughlin K, Lubula MY, Gay JC, Dest A, Gao C, Phillips M, Tonelli M, Cornilescu G, Marunde MR, Evans CM, Boyson SP, Carlson S, Keogh MC, Markley JL, Frietze S, and Glass KC. (2020) Structural insights into the recognition of mono- and di-acetyled histones by the ATAD2B bromodomain. J. Med. Chem. Oct. 21, 2020. DOI: https://doi.org/10.1021/acs.jmedchem.0c01178. PMID: 33084328

Obi JO, Lubula MY, Cornilescu G, Henrickson A, McGuire K, Evans CM, Phillips M, Demeler B, Markley JL and Glass KC. (2020) The BRPF1 bromodomain is a molecular reader of di-acetyllysine. Current Research in Structural Biology. 2020 May; 2:104-115. DOI: https://doi.org/10.1016/j.crstbi.2020.05.001. PMID: 33554132 

Gay JC, Eckenroth BE, Evans CE, Langini C, Carlson C, Lloyd JT, Caflisch A and Glass KC. (2019) Disulfide bridge formation influences ligand recognition by the ATAD2 bromodomain.

 Proteins: Structure, Function, and Bioinformatics, Feb;87(2):157-167. doi: 10.1002/prot.25636. Epub 2018 Dec 27. PMID: 30520161

 

Gay JC, Eckenroth BE, Evans CE, Langini C, Carlson C, Lloyd JT, Caflisch A and Glass KC. Disulfide bridge formation influences ligand recognition by the ATAD2 bromodomain. Accepted in Proteins: Structure, Function, and Bioinformatics, Sept 2018.

Lloyd JT and Glass KC. Biological function and histone recognition of family IV bromodomain-containing proteins. J Cell Physiol, 233(3):1877-1886, 2018. PMID: 28500727

Hassan HE, Keita JA, Narayan L, Brady SM, Frederick R, Carlson S, Glass KC, Natesan S, Buttolph T, Fandy TE. The combination of dimethoxycurcumin with DNA methylation inhibitor enhances gene re-expression of promoter-methylated genes and antagonizes their cytotoxic effect. Epigenetics, 1-10, 2016. PMID: 27588609

Kim S, Natesan S, Cornilescu G, Carlson S, Tonelli M, McClurg UL, Binda O, Robson CN, Markley JL, Balaz S, Glass KC. Mechanism of Histone H3K4me3 Recognition by the Plant Homeodomain of Inhibitor of Growth 3. J Biol Chem, 291(35):18326-41, 2016. PMID: 27281824

Hassan HE, Carlson S, Abdallah I, Buttolph T, Glass KC, Fandy TE. Curcumin and dimethoxycurcumin induced epigenetic changes in leukemia cells. Pharm Research, 32(3):863-75, 2015. PMID: 25186441

Lubula MY, Eckenroth BE, Carlson S, Poplawski A, Chruszcz M, and Glass KC. Structural insights into recognition of acetylated histone ligands by the BRPF1 bromodomain. FEBS Letters, 588(21):3844-54, 2014. PMID: 25281266

Lubula M, Poplawski A and Glass KC. Crystallization and preliminary X-ray diffraction analysis of the BRPF1 bromodomain in complex with its H2AK5ac and H4K12ac histone-peptide ligands. Acta Crystallogr F Struct Biol Commun, 70(Pt 10):1389-93, 2014. PMID: 25286946

Carlson S and Glass KC. The MOZ histone acetyltransferase in epigenetic signaling and disease. J Cel. Physiol, 229(11):1571-4, 2014. PMID: 24633655

Poplawski A, Hu K, Lee W, Natesan S, Peng D, Carlson S, Shi X, Balaz S, Markley JL, Glass KC. Molecular insights into the recognition of N-terminal histone modifications by the BRPF1 bromodomain. J Mol Biol, 426: 1661-1676, 2014. PMID: 24333487

Lalonde ME, Glass KC, Avakumov N, Joncas FH, Saksouk N, Paquet E, Holliday M, Tan S, Yang XJ, Kutateladze TG and Côté J. Exchange of associated factors directs a switch in HBO1 acetyltransferase histone tail specificity. Genes Dev, 27(18):2009-24, 2013. PMID: 24065767

Lee W, Hu K, Toneli M, Bahrami A, Neuhardt E, Glass KC and Markley JL. Fast automated protein NMR data collection and assignment by ADAPT-NMR on Bruker spectrometers. J Magn Reson, 236:83-8, 2013. PMID: 24091140

Yuan CC, Matthews AG, Jin Y, Chen CF, Chapman BA, Ohsumi TK, Glass KC, Kutateladze TG, Borowsky ML, Struhl K, Oettinger MA. Histone H3R2 symmetric dimethylation and histone H3K4 trimethylation are tightly correlated in eukaryotic genomes. Cell Reports. 1(2):83-90, 2012. PMID: 22720264

Avvakumov N, Lalonde ME, Saksouk N, Paquet E, Glass KC, Landry AJ, Doyon Y, Cayrou C, Robitaille GA, Richard DE, Yang XJ, Kutateladze TG and Côté J. Conserved molecular interactions within the HBO1 acetyltransferase complexes regulate cell proliferation. Mol Cell Biol. 32(3):689-703, 2012.PMID: 22144582

Hom, RA, Chang, PY, Roy, S*, Musselman, CA*, Glass, KC*, Selezneva, AI, Gozani, O, Ismagilov, RF, Cleary, MI and Kutateladze, TG. Molecular mechanism of MLL PHD3 and RNA recognition by the Cyp33 RRM domain. J Mol Biol. Jul 9;400(2):145-54, 2010. PMID: 20460131

Roy S, Musselman CA, Kachirskaia I, Hayashi R, Glass KC, Nix JC, Gozani O, Appella E, Kutateladze TG. Structural insight into p53 recognition by the 53BP1 tandem Tudor domain. J Mol Biol. 14;398(4):489-96, 2010. PMID: 20307547

Champagne KS and Kutateladze TG.  Structural insight into histone recognition by the ING PHD fingers. Current Drug Targets. 10:432-41, 2009. PMID: 19442115

Hung T*, Binda O*, Champagne KS*, Kuo AJ, Johnson K, Chang HY, Simon MD, Kutateladze TG and Gozani O.  ING4 mediates crosstalk between histone H3 K4 trimethylation and H3 acetylation to attenuate cellular transformation.Mol Cell. 33:248-256, 2009. PMID: 19187765

Saksouk N, Avvakumov N*, Champagne KS*, Hung T*, Doyon Y, Cayrou C, Paquet E, Ulla M, Landry AJ, Côté V, Yang XJ, Gozani O, Kutateladze TG and Côté J. HBO1 HAT complexes target chromatin throughout gene coding regions via multiple PHD finger interactions with histone H3 tail. Mol Cell. 33:257-265, 2009. PMID: 19187766

Champagne KS, Saksouk N, Peña PV, Johnson K, Ullah M, Yang XJ, Côté J, Kutateladze TG. The crystal structure of the ING5 PHD finger in complex with an H3K4me3 histone peptide. Proteins. 72: 1371-6, 2008. PMID: 18623064

Peña PV, Hom RA, Hung T, Lin H, Kuo AJ, Wong RP, Subach OM, Champagne KS, Zhao R, Verkhusha VV, Li G, Gozani O, Kutateladze TG. Histone H3K4me3 binding is required for the DNA repair and apoptotic activities of ING1 tumor suppressor. J Mol Biol. 380: 303-12, 2008. PMID: 18533182

Matthews AG, Kuo AJ, Ramón-Maiques S, Han S, Champagne KS, Ivanov D, Gallardo M, Carney D, Cheung P, Ciccone DN, Walter KL, Utz PJ, Shi Y, Kutateladze TG, Yang W, Gozani O, Oettinger MA. RAG2 PHD finger couples histone H3 lysine 4 trimethylation with V(D)J recombination. Nature. 450 (7172): 1106-10, 2007. PMID: 18033247

Champagne KS, Piscitelli E, Francklyn CS. Substrate recognition by the hetero-octameric ATP phosphoribosyltransferase from Lactococcus lactis. Biochemistry 45:14933-43, 2006. PMID:  17154531

Champagne KS, Sissler M, Larrabee Y, Doublié S, Francklyn CS. Activation of the hetero-octameric ATP phosphoribosyl transferase through subunit interface rearrangement by a tRNA synthetase paralog. J Biol Chem. 280: 34096-34104, 2005. PMID: 16051603

Bovee ML, Champagne KS, Demeler B, Francklyn CS. The quaternary structure of the HisZ-HisG N-1-(5'-phosphoribosyl)-ATP transferase from Lactococcus lactis. Biochemistry.  41: 11838-11846, 2002. PMID: 12269828


*These authors contributed equally to the work.