Collaborative Faculty Publications

 

Representative publications with trainees from the past 5 years

JASON BATES

 

T.F. Schuessler, S.B. Gottfried, P. Goldberg, R.E. Kearney and J.H.T. Bates.An adaptive filter to reduce cardiogenic oscillations on esophageal pressure signals. Annals of Biomedical Engineering. 26: 260-267, 1998.

 

N. Shinozuka, T. Nemoto and J.H.T. Bates. Isovolume bronchoconstriction by vagal stimulation in dogs: effects of lung inflation pressure. Respiration Physiology. 111: 79-88, 1998.

 

A. Adler, N. Shinozuka, Y. Berthiaume, R. Guardo, and J.H.T. Bates.  Electrical impedance tomography can monitor dynamic hyperinflation in dogs. Journal of Applied Physiology. 84: 726-732, 1998.

 

A. Adler, E.A. Cowley, J.H.T. Bates and D.H. Eidelman. Airway-parenchymal interdependence after airway contraction in rat lung explants.  Journal of Applied Physiology. 85: 231-237, 1998.

 

N. Shinozuka, J.-P. Lavoie, J.G. Martin and J.H.T. Bates.  Effect of time-varying load on degree of bronchoconstriction in the dog. Journal of Applied Physiology. 85: 1464-1470, 1998.

 

E. Bijaou, S.A. Tuck, J.E. Remmers, and J.H.T. Bates. Estimating respiratory mechanics in the presence of flow limitation. Journal of Applied Physiology. 86: 418-426, 1999

 

T. Hirai, K.A. McKeown, R.F.M. Gomes and J.H.T. Bates. Effects of lung volume on lung and chest wall mechanics in rats.  Journal of Applied Physiology. 86: 16-21, 1999.

 

T. Nemoto, G. Hatzakis, C.W. Thorpe, R. Olivenstein, S. Dial and J.H.T. Bates. Automatic control of pressure support ventilation using fuzzy logic. American Journal of Respiratory and Critical Care Medicine. 160: 550-556, 1999.

 

A. Adler and J.H.T. Bates. A micromechanical model of airway-parenchymal interdependence. Annals of Biomedical Engineering. 28: 309-317, 2000.

 

R.F.M. Gomes, X. Shen, R. Ramchandani, R.S. Tepper and J.H.T. Bates. Comparative respiratory system mechanics in rodents. Journal of Applied Physiology. 89: 908-916, 2000.

 

A.-M. Lauzon and J.H.T. Bates. Kinetics of respiratory system elastance following airway challenge in dogs. Journal of Applied Physiology. 89: 2023-2029, 2000.

 

R.F.M. Gomes, F. Shardonofsky, D.H. Eidelman, and J.H.T. Bates. Respiratory mechanics and lung development in the rat from early age to adulthood. Journal of Applied Physiology. 90: 1631-1638, 2001.

 

E. Bijaoui, P.F. Baconnier, and J.H.T. Bates. Respiratory mechanical impedance determined from cardiogenic oscillations. Journal of Applied Physiology. 91: 859-865, 2001.

 

T. Hirai and J.H.T. Bates. Effects of deep inspiration on bronchoconstriction in the rat. Respiration Physiology. 127: 201-215, 2001.

 

S.Wagers, L.Lundblad, H.T. Moriya, J.H.T. Bates,  and C.G. Irvin. Nonlinearity of respiratory mechanics during bronchoconstriction in mice with airway inflammation. Journal of Applied Physiology.  92: 1802-1807, 2002.

 

E.L. Bijaoui, V. Champagne P. F. Baconnie, R. J. Kimoff and J.H.T. Bates. Mechanical properties of the lung and upper airways in patients with sleep-disordered breathing. American Journal of Respiratory and Critical Care Medicine. 165: 1055-1061, 2002.

 

R.F.M. Gomes  and J. H.T. Bates. Geometric determinants of airway resistance in two isomorphic rodent species. Respiration Physiology & Neurobiology. 130: 317-325, 2002.

 

L. Lundblad, C.G. Irvin,  A. Adler, and J.H.T. Bates. A reevaluation of the validity of unrestrained plethysmography in mice. Journal of Applied Physiology. 93: 1198-1207, 2002.

 

G. Allen, L.K.A. Lundblad, P.E. Parsons, and J.H.T. Bates. The transient mechanical benefits of a deep inflation in the injured mouse lung. Journal of Applied Physiology. 93: 1709-1715, 2002.

 

H.T. Moriya, J.C.T.B. Moraes, and J.H.T. Bates. Nonlinear and frequency dependent mechanical behavior of the mouse respiratory system. Annals of Biomedical Engineering. 31: 318-326, 2003.

 

 

RALPH BUDD

 

Kennedy, N.J., and R.C. Budd. Phosphorylation of FADD/MORT1 and Fas by kinases that associate with the membrane-proximal cytoplasmic domain of Fas. J. Immunol. 160:4881-4888, 1998.

 

Vincent, M.S., Roessner, K., Sellati, T., Huston, C.D., Sigal, L.H., Behar, S.M, Radolf, J.D, and Budd, R.C. Lyme arthritis synovial  T Cells respond to Borrelia burgdorferi lipoproteins and lipidated hexapeptides. J. Immunol. 161:5762-5771, 1998.

 

Russell, J.Q., Morrissette, G.J., Weidner, M., Vyas, C., Aleman-Hoey, D., and Budd, R.C. Liver damage results from CD8+ T Cells triggered by high affinity peptide antigens. J. Exp.Med. 188:1147-1157, 1998.

 

Mixter, P.F., Russell, J.Q., Morrissete, G.J., Charland, C., Aleman-Hoey, D., and Budd, R.C. A model for the origin of TCR+ CD4-CD8- B220+ cells based on high affinity signals.  J. Immunol. 162:5747-5756, 1999.

 

Wilson, D.J., Alessandrini, A., and Budd, R.C.  MEK1 activation rescues T Cells from Fas-induced apoptosis.  Cell. Immunol. 194:67-77, 1999.

 

Kennedy, N.J., Kataoka, T., Tschopp, J., and Budd, R.C. Caspase activation is required for T cell proliferation. J. Exp. Med. 190:1891-1895, 1999.

 

Kataoka, T., Budd, R.C., Holler, N., Thome, M., Martinon, F., Irmler, M., Burns, K., Hahne, M., Kennedy, N.J., and Tschopp, J. The caspase-8 inhibitor FLIIP promotes activation of NF-kB and ERK signaling pathways. Curr. Biol. 10:640-648, 2000.

 

Kennedy, N., Russell, J.Q., Michail, N., and Budd, R.C. Liver Damage by Infiltrating CD8+ T Cells is Fas      Dependent.  J. Immunol. 167:6654-62, 2001.

 

Budd, R.C.  Death receptors couple to both cell proliferation and apoptosis.  J. Clin. Invest. 109:437442, 2002.

 

Huber, S., Shi, C., and Budd, R.C.  T cells promote a Th1 response during infection by selective Fas-dependent killing of Th2 cells.  J. Virol. 76:6487-6494, 2002.

 

Lens, S.M.A., Kataoka, T., Fortner, K.A., Ferrero, I., MacDonald, H.R., Hahne, M., Beermann, F., Attinger, A., Orbea, H.-A., Budd, R.C., and Tschopp, J.  The caspase 8 inhibitor c-FLIPL modulates T cell receptor-induced proliferation but not activation-induced cell death of lymphocytes.  Mol. Cell Biol. 22:5419-5433, 2002..

 

Roessner K, Wolfe J, Shi C, Sigal LH, Huber S, and Budd RC:  High expression of Fas-ligand by synovial fluid-derived gd T cells.  Submitted.

 

 

GERALD DAVIS

 

Singh N,  Davis GS. Occupational and Environmental Lung Disease.  Current Opinion in Pulmonary Medicine 2002;8:117-125.

 

Paul DS, Hemenway DR, Davis GS.  The role of mast cells in silicosis and pulmonary fibrosis.      Am J Respir Crit Care Med 2000;161:52A.

 

 

SALLY A. HUBER

 

Gauntt CJ, Sakkinen PA, Rose NR, and Huber SA:  Picornaviruses: Immunopathology and autoimmunity, In:Cunningham MW, Fujinami R (Ed.): Effects of Microbes on the Immune System.  Lippincott Raven Publishers, Philadelphia, PA., 1999.

 

Huber SA, Gauntt CJ, and Sakkinen PA: Enteroviruses and myocarditis: Viral pathogenesis through replication, cytokine induction, and immunopathogenicity. In:Maramorosch K, Murphy FA, Shatkin AJ (Ed.):  Advances in Viral Research.  Academic Press, San Diego, CA., Vol. 51:35-82, 1999.

 

Huber SA, Gauntt CJ:  Antigenic Mimicry Between Self and Coxsackievirus Protein Leads to Both Humoral and Cellular Autoimmunity to Heart Proteins.  In: Cunningham MW, Fujinami R (Eds.): Molecular Mimicry in Disease.  ASM Press, Chapter 5:pages 57-68,  2000.

 

Huber SA, Graveline D, Newell MK, Born W and O’Brien, RL.  Vg1+ T  cells  suppress Vg4+ T cells promote susceptibility to coxsackievirus B3-induced myocarditis in mice.  Journal of Immunology, 165:4174-4181, 2000. 

 

Huber SA, Sakkinen P, David C, Newell MK and Tracy RP.  T helper-cell phenotype regulates 

atherosclerosis in mice under conditions of mild hypercholesterolemia.  Circulation, 103:2610-2616, 2001.

 

Huber SA, Graveline D, Born WK, and O’Brien RL: Cytokine production by gd  + T cell subsets is an important factor in determining CD4+ Th Cell phenotype susceptibility of  BALB/c mice to coxsackievirus B3-Induced Myocarditis. J of Virology, 75(13):5860-5868, 2001.

 

O’Brien RL, Yin X, Huber SA, Ikuta K, and Born K:  Depletion of a gd T Cell Subset can Increase Host Resistance to a Bacterial Infection.  Journal of Immunology, 165:1109-1115, 2000.

Huber SA, Graveline D, Dahl P, Seavey M, Born W, O’Brien R, Tracy, R:  T cells expressing the gamma delta T cell receptor promote fatty streak formation in mice under mild hypercholesterolemia.  Submitted, ATVB, 2002.     

 

Roessner K, Wolfe J, Shi C, Sigal LH, Huber S, and Budd RC:  High expression of Fas-ligand by synovial fluid-derived gd T cells.  Submitted.

 

 

CHARLES IRVIN

 

Kaminsky DA, Wenzel SE, Carcano C, Gurka D, Feldsien D, Irvin CG.  Hyperpnea-induced changes in parenchymal lung mechanics in normals and asthmatics.  Am J Respir Crit Care Med 155:1260-1266, 1997.

 

Kaminsky DA, Irvin CG.  Lung Function in asthma.  In: Asthma.  Eds. Barnes PJ,  Grunstein MM, Leff A, Woolcock, AJ.  Lippincott-Raven Publishers, New York. 89:1277-1300, 1997. 

 

Irvin CG, Tu Y-P, Sheller JR, Funk CD.  5-Lipoxygenase products are necessary for ovalbumin-induced airway responsiveness in mice.  Am J Physiol.  272:1053-1058, 1997.

 

Takeda K, Hamelmann E, Joetham A, Shultz LD, Larsen GL, Irvin CG, Gelfand EW.  Development of eosinophilic airway inflammation and airway hyperresponsiveness in mast cell-deficient mice.  J Exp Med 186:449-454, 1997.

 

Homma T, Irvin, CG.  Bradykinin-induced bronchospasm in the rat in vivo:  a role for nitric oxide modulation.  Eur Resp. J. 13:313-320, 1999.

 

Wagers, SS, Irvin CG. The pharmacology of aerosolized airway challenge.  Resp.Care Clin. N.Am.  5(4): 633-648, 1999.

 

Wagers SS, Bouder TG, Kaminsky DA, Irvin CG.  The invaluable pressure-volume curve. Chest. 117(2):578-83. 2000.

 

Kaminsky DA, Bates JHT, Irvin CG.  Effects of cool, dry air stimulation on peripheral lung mechanics in asthma.  Am. J. Resp. Crit. Care Med.  162(1):179-86. 2000.

 

Takeda K, Haczku A, Lee JJ, Irvin CG, Gelfand EW.  Strain dependence of airway hyperresponsiveness reflects differences in eosinophils localization in the lung.  Am J Physiol Lung Cell Mol Physiol.  281(2):L394-402, 2001

 

Kaminsky DA, Irvin CG. New insights from lung function.  Current Opinion in Allergy and Clinical Immunology.  1:205-209, 2001

 

Wagers S, Lundblad L, Moriya HT, Bates JHT, Irvin CG.  Nonlinearity of respiratory mechanics during bronchoconstriction in mice with airway inflammation.  J Appl Physiol.  92: 1802-1807, 2002. 

 

Poynter ME, Irvin CG, Janssen-Heininger YMW.  Rapid activation of nuclear factor Kappa-B in airway epithelium in a murine model of allergic airway inflammation.  Am J Pathol.  160 (4): 1325-1334, 2002.

 

Tomioka S, Bates JHT, Irvin CG.  Airway and tissue mechanics in a murine model of asthma: Alveolar capsule vs. forced oscillations.   J Appl Physiol. 93: 263-270, 2002.

 

Wagers S, Jaffe EF, Irvin CG.  Development, Structure, and Physiology in Normal and Asthmatic   Lung.  Allergy Principle and Practice 6th edition. Eds. E Middleton, Jr., 2003

 

 

YVONNE JANSSEN-HEININGER

 

Janssen YMW, Soultanakis, R, Steece K, Heerdt E, Singh RJ, Joseph J, and Kalyanaraman B:  Depletion of nitric oxide causes cell cycle alterations, apoptosis and oxidative stress in pulmonary cells. Am. J. Physiol. 275 (Lung Cell. Mol. Physiol. 19) L1100-L1109, 1998.

 

Poynter ME, Janssen-Heininger YMW, Buder-Hoffman S, Taatjes DJ, and Mossman BT:

Measurement of oxidant-induced signal transduction proteins using cell imaging. Free Rad. Biol. Med. 27:1164-1172, 1999.

 

Kaminsky DA, Mitchell J, Carroll N, James A, Soultanakis R, and Janssen Y: Nitrotyrosine formation in the airways and lung parenchyma of patients with asthma. J Allergy Clin Immunol. 104(4 Pt 1):747-754, 1999.

 

Soultanakis RP, Melamede RJ, Bespalov IA, Wallace SS, Beckman KB, Ames BN, Taatjes DJ and

Janssen-Heininger YMW: Fluorescence detection of 8-oxoguanine in nuclear and mitochondrial DNA of cultured cells using a recombinant Fab and confocal scanning laser microscopy.  Free Radic. Biol. Med.  28:987-998, 2000.

 

Janssen-Heininger YMW, Poynter M, and Baeuerle P: Recent advances towards understanding redox mechanisms in the activation of nuclear factor kB.  Invited contribution to a Forum on Signal Transduction by Oxidant Stresses.  Free Radic. Biol. Med. 28:1317-1327, 2000.

 

Fine A, Janssen-Heininger Y, Soultanakis RP, Swisher SG and Uhal BD:  Apoptosis in lung pathophysiology.  Am. J. Physiol. Lung Cell Mol. Physiol. 279:L423-L427, 2000.

 

Persinger RL, Blay WM, Heintz NH, Hemenway DR and Janssen-Heininger YMW:  Nitrogen dioxide induces death in lung epithelial cells in a density-dependent manner.  Am. J. Respir. Cell Mol. Biol. 24:583-590, 2001. (Cover story).

 

Langen RCJ, Schols AMWJ, Kelders MCJM, Wouters EFM and Janssen-Heininger YMW:

Inflammatory cytokines inhibit myogenic differentiation through activation of nuclear factor-kappaB. FASEB J. 15:1169-1180, 2001.

 

Persinger RL,  Melamede B,  Bespalov I, Wallace S, Taatjes  DJ,  Janssen-Heininger YMW.  Imaging

techniques used for the detection of 8-oxoguanine adducts and DNA repair proteins in cells and tissues. Exp Gerontol.  36(9):1483-1494, 2001.

 

Korn S, Wouters EFM, Vos N, Janssen-Heininger, YMW: Cytokine-induced activation of nuclear factor kappa B is inhibited by hydrogen peroxide through oxidative inactivation of I κB kinase.  J. Biol. Chem. 276(38) 35693-35700, 2001.

 

Poynter M, Irvin C, and Janssen-Heininger YMW: Rapid activation of NF-kB and NF-kB regulated genes in a murine model of allergic airway disease. Am. J. Pathol. 160 (4):1325-1334, 2002.

 

Langen RC, Kelders MC, Wouters EF, Schols AM and Janssen-Heininger YM:  Tumor necrosis factor

alpha inhibits myogenic differentiation through redox dependent and independent pathways. Am. J. Physiol Cell Physiol. 283(3):C714-721, 2002.

 

Persinger RL, Poynter ME, Ckless K, Janssen-Heininger YMW. Molecular mechanisms of nitrogen dioxide induced epithelial injury in the lung. Mol. Cell. Biochem. 234-235 (1-2) 71-80, 2002.

 

Persinger RL, Poynter ME, Ckless K, Janssen-Heininger YMW. Molecular mechanisms of nitrogen dioxide induced epithelial injury in the lung. Mol. Cell. Biochem. 71-80:234-235, 2002

 

Janssen-Heininger YMW, Persinger RL, Korn SH, Pantano C, McElhinney B, Reynaert N, Langen RCJ, Ckless K, Ranjan P, Poynter M. Reactive nitrogen species and cell sinaling:  implication for death or survival of lung epithelium. Am J Respir Crit Care Med. 166:S9-S16, 2002

 

Poynter ME, Irvin CG and Janssen-Heininger YMW:  A prominent role for airway epithelial NF-kB activation in LPS induced airway inflammation.  J. Immunol. (In press).

 

 

DAVID KAMINSKY

 

Paul DS, Kaminsky DA.  A New England logger with a diffuse pneumonia. Chest 2000;117:244-247.

 

Wagers SS, Bouder TG, Kaminsky DA, Irvin CG.  The invaluable pressure-volume curve. Chest 2000;117:578-583.

 

Redden S, Hunton D, Kaminsky DA.  Diagnosis of a space-occupying lesion by PFTs.  Respir Care 2003;48:138-141.

 

Allen G, Kaminsky DA.  Asthma.  In:  Wiener-Kronish JP, Parsons P, eds. Critical Care Secrets, 3rd ed. Philadelphia:  Hanley & Belfus, Inc., 2002.


POLLY PARSONS

 

Parsons PE, Moss M, Vannice J, Moore EE, Moore FA, Repine JE.  Circulating IL-1ra and IL-10 levels are increased but do not predict the development of ARDS in at risk patients. Am J. Resp and Crit Care Med, 155:1469-73, 1997.

 

Moss M, Parsons PE.  What is the acute respiratory distress syndrome?   J. Intensive Care Medicine.  13:59-67, 1998.

 

Moss M, Steinberg KP, Guidot DM, Duhon GF, Treece P, Wolken R, Hudson LD, Parsons PE.  The effect of chronic alcohol abuse on the incidence of ARDS and the severity of multiple organ dysfunction syndrome in adults with septic shock; An interim and multivariant analysis.  Chest 116:97 S, 1999.

 

Moss M, Steinberg KP, Guidot DM, Duhon GF, Treece P, Wolken R, Hudson LD, Parsons PE.  Diabetic patients with septic shock have a decreased incidence of the acute respiratory distress syndrome.   Critical Care Medicine, 28:2187-2192,2000

 

Allen G, Parsons PE, Bates J.  The transient mechanical benefits of a deep inflation in the injured mouse lung.  JAP 2002;93:1709-1715.

 

Moss M, Parsons PE, Steinberg KP, Hudson LD, Guidot DM, Burnham EL, Eaton S, Cotsonis GA.  Chronic alcohol abuse is associated with an increased incidence of ARDS and severity of multiple organ dysfunction in patients with septic shock.  Critical Care Medicine  2003; 31:869-877.

 

 

MERCEDES RINCON

 

Yang D., Conze D.B., Whitmarsh A.J., Barrett T., Davis R.J., Rincón M. and Flavell, R.A. (1998) “Differentiation of CD4+ cells to Th1 cells requires MAP kinase JNK2”. Immunity  9, 575-585.

 

Rincón, M., Whitmarsh, A., Yang, D.D., Weiss, L., Dérijard, B., Jayaraj, P., Davis, R.J. and Flavell, R.A. (1998) “The JNK pathway regulates the in vivo deletion of immature CD4+CD8+ thymocytes. J. Exp. Med. 188, 1817-1830.

 

Diehl, N., Enslen, H., Fortner, K.A., Stetson, N., Charland, C., Flavell, R.A., Davis, R.J. and Rincón, M. (2000). “Activation of the p38 MAP kinase pathway arrests in vivo thymocyte differentiation and cell cycle progression”. J. Exp. Med. 191, 321-334

 

Weiss, L., Whitmarsh, A. Yang, D. Flavell, R.A., Davis, R.J. and Rincón, M. (2000) “Regulation of c-Jun NH2-terminal kinase  (Jnk)gene expression during T cell activation” J. Exp. Med. 191, 139-145

 

Rincón, M., Conze, D., Weiss, L., Diehl, N., Fortner, K.A., Yang, D., Flavell, R.A., Enslen, H., Whitmarsh, A.and Davis, R. (2000) “Do T cells care about the MAP kinases signaling pathways?” Imm. Cell. Biol. 78, 166-175.

 

Conze, D., Lumsden, J., Enslen, H., Davis R.J., Le Gros, G. and Rincón, M. (2000) “Activation of p38 MAP kinase in T cells facilitates the immune response to the influenza virus”. Mol. Immunol. 37, 503-513.

 

Diehl, S., Anguita, J., Hoffmeyer, A., Zapton, T., Ihle, J.N., Fikrig, E., and Rincón, M.,(2000) “Inhibition of Th1 differentiation by IL-6 is mediated by SOCS1”. Immunity. 13, 805-815.

 

Conze, D., Weiss, L., Bhushan, A., Johnson, P., and Rincón, M., (2001). “Autocrine production of IL-6 causes multidrug resistance in breast cancer cells”. Cancer Research  61, 8851-8858.

 

Conze, D., Krahl, T., Kennedy, N., Weiss, L., Lumsden, J., Hess, P. Le Gros, G., Davis, R.J. and

Rincón, M., (2002) “JNK1 and JNK2 have distinct roles in CD8+ T cell activation”. J. Exp. Med. 195, 811-823.

 

Diehl, S., Chow, C-W., Weiss, L., Palmestoshfer, A., Twardzik, T., Rounds, L., Serfling, E., Davis, R.J., Anguita, J. and Rincón, M., (2002) “Induction of NFATc2 expression by IL-6 promotes Th2 differentiation”  J. Exp. Med. 196, 39-49.

 

Diehl, S. and Rincón, M. (2002) “The two faces of IL-6 on Th1 and Th2 differentiation”. Mol. Immunol. In press

 

McLellan, B.S., Rincon, M., Bushway, P., Flavell, R.A., and Budd, R.C.  Elevated NFAT transcriptional activity in lpr mature T cells.  Submitted.

 

 

 

BURTON SOBEL

 

Absher, P. M., Schneider, D. J., Russell, J. C., and Sobel, B. E.: Increased proliferation of explanted vascular smooth muscle cells: A marker presaging atherogenesis.  Atherosclerosis 131:187-194, 1997.

 

Ehrmann, D. A., Schneider, D. J., Sobel, B. E., Cavaghan, M. K., Imperial, J., Rosenfield, R. L., and Polonsky, K. S.: Troglitazone improves defects in insulin action, insulin secretion, ovarian steroidogenesis, and fibrinolysis in women with polycystic ovary syndrome.  J. Clin. Endocrinol. Metab.82:2108-2116, 1997.

 

Schneider, D. J., Tracy, P. B., Mann, K. G., and Sobel, B. E.: Differential effects of anticoagulants on the activation of platelets ex vivo.  Circulation 96:2877-2883, 1997.

 

Schneider, D. J., Ricci, M. A., Taatjes, D. J., Baumann, P. Q., Reese, J. C., Leavitt, B. J., Absher, M., and Sobel, B. E.: Changes in arterial expression of fibrinolytic system proteins in atherogenesis.  Arterioscler. Thromb. Vasc. Biol.17:3294-3301, 1997. 

 

Calles-Escandon, J., Mirza, S., Sobel, B. E., and Schneider, D. J.: Induction of hyperinsulinemia combined with hyperglycemia and hypertriglyceridemia increases plasminogen activator inhibitor 1 in blood in normal human subjects.  Diabetes 47:290-293, 1998.

 

Sobel, B. E., Woodcock-Mitchell, J., Schneider, D. J., Holt, R. E ., Marutsuka, K., and Gold, H.: Increased plasminogen activator inhibitor type-1 in coronary artery atherectomy specimens from type 2 diabetic compared with nondiabetic patients: A potential factor predisposing to thrombosis and its persistence.  Circulation 97:2213-2221, 1998.

 

Schneider, D. J., Taatjes, D. J, Howard, D.B., and Sobel, B. E.: Increased reactivity of platelets induced by fibrinogen independent of its binding to the IIb-IIIa surface glycoprotein: A potential contributor to cardiovascular risk.  J. Am. Coll. Cardiol. 33:261-266, 1999.

                                                                                                                                               

Absher, P. M., Schneider, D. J., Baldor, L. C., Russell, J. C., and Sobel, B. E.: The retardation of vasculopathy induced by attenuation of insulin resistance in the corpulent JCR:LA-cp rat is reflected by decreased vascular smooth muscle cell proliferation in vivo.  Atherosclerosis 143:245-251, 1999.

 

Holmes, M. B., Sobel, B. E., Howard, D. B., and Schneider, D. J.: Differences between activation thresholds for platelet P-selectin and glycoprotein IIb-IIIa expression and their clinical implications.  Thromb. Res. 95:75-82, 1999.

 

Holmes, M. B., Schneider, D. J., Hayes, M. G., Sobel, B. E., and Mann, K. G.: Novel, bedside, tissue factor-dependent clotting assay permits improved assessment of combination antithrombotic and antiplatelet therapy.  Circulation 102:2051-2057, 2000.

 

Taatjes, D. J., Wadsworth, M. P., Schneider, D. J., and Sobel, B. E.: Improved quantitative characterization of atherosclerotic plaque composition with immunohistochemistry, confocal fluorescence microscopy, and computer-assisted image analysis.  Histochem. Cell Biol. 113:161-173, 2000.

 

Kabbani, S. S., Watkins, M. W., Ashikaga, T., Terrien, E. F., Holoch, P. A ., Sobel, B. E., and Schneider, D. J.: Platelet reactivity characterized prospectively: A determinant of outcome 90 days after percutaneous coronary intervention.  Circulation 104:181-186, 2001.

 

Nordt, T. K., Bode, C., and Sobel, B. E.: Stimulation in vivo of expression of intra-abdominal adipose tissue plasminogen activator inhibitor type-1 by proinsulin.  Diabetologia 44:1121-1124, 2001.

 

Nordt, T. K., Lutzi, S., Ruef, J., Peter, K., Klar, E., Kubler, W., Sobel, B. E., and Bode, C.: Attenuation by fibrates of expression of plasminogen activator inhibitor type-1 expression in cultured human arterial smooth muscle cells.  Thromb. Haemost. 86:1305-1313, 2001.

 

Taatjes, D. J., Schneider, D. J., Bovill, E. G., and Sobel, B. E.: Microscopy-based imaging of the pathogenesis of cardiovascular disease.  Microscopy and Analysis, Sept.:21-23, 2001.

 

Wadsworth, M. P., Sobel, B.E., Schneider, D. J., and Taatjes, D. J.: Delineation of the evolution of compositional changes in atheroma.  Histochem. Cell Biol. 118:59-68, 2002.

 

Chen, Y., Sobel, B. E., and Schneider, D. J.: Effect of fatty acid chain length and thioesterification on the augmentation of expression of plasminogen activator inhibitor-1.  Nutrition, Metabolism, and Cardiovascular Disease, in press.

 

Goto, D., Fujii S., Taneko, T., Furumoto, T., Sagawara, T., Zaman, T.A.K.M., Imagawa, S., Dong, J., Nakai, Y., Mishima, T., Sobel, B. E., and Kitabatake A.: Intracellular signal transduction modulating expression of plasminogen activator inhibitor-1 in adipocytes.  Biochem. Pharm., in press.

 

Cefalu, W. T., Schneider, D. J., Carlson, H. E., Migdal, P., Lim, L. G., Izon, M. P., Kapoor, A., Bell-Farrow, A., Terry, J. G., and Sobel, B. E.: Effect of combination glipizide GITS/metformin on fibrinolytic and metabolic parameters in poorly controlled, type 2 diabetic subjects.  Diabetes Care 25:2123-2128, 2002.

 

Kabbani, S.  S., Watkins, M. W., Ashikaga, T., Terrien, E. F., Sobel, B. E., and Schneider, D. J.: Platelet reactivity before percutaneous coronary intervention presages cardiac risk one year later.  Am. J. Cardiol., in press.

 

Furumoto, T., Fujii, S., Onozuka, H., Zaman, A.K.M.T., Goto, D., Sugawara, T., Mikami, T., Watanabe, S., Abe, K., Terauchi, Y., Kadowaki, T., Sobel, B. E., and Kitabatake, A.: Persistence of induction of cardiomyopathic effects by insulin resistance despite loss of insulin receptor substrate-1 signaling.  Circulation, in press.

 

Nordt, T. K., Eschenfelder, E., Peter, K., Sobel, B. E., and Bode, C.: Independence of growth factor induced plasminogen activator inhibitor type-1 (PAI-1) expression from the 4G/5G polymorphism of the PAI-1 gene.  Thromb. Haemost., in press.

 

 

DOUGLAS TAATJES

 

Mount, S.L., Schwarz, J.E., and Taatjes, D.J. (1997) Prolonged storage of fixative for electron microscopy: Effects on tissue preservation for diagnostic specimens.  Ultrastruct. Pathol.  21, 195-200.

 

Liu, S., Weaver, D.L., and Taatjes, D.J. (1997) Three-dimensional reconstruction by confocal laser scanning microscopy in routine pathologic specimens of benign and malignant lesions of          the human breast. Histochem. Cell Biol.  107, 267-278.

 

Davis, W.P., Janssen, Y.M.W., Mossman, B.T., and Taatjes, D.J. (1997) Simultaneous triple fluorescence detection of mRNA localization, nuclear DNA, and apoptosis in cultured cells using confocal laser scanning microscopy. Histochem. Cell Biol. 108, 307-311.

 

Jung, M., Davis, W.P., Taatjes, D.J., Churg, A., and Mossman, B.T. (2000) Asbestos and cigarette smoke cause increased DNA strand breaks and necrosis in bronchiolar epithelial cells in vivo. Free Radic. Biol. Med. 28, 1295-1299.

 

Manning, C.B., Cummins, A.B., Jung, M.W., Berlanger, I., Timblin, C.R., Palmer, C.,Taatjes, D.J., Hemenway, D., Vacek, P., and Mossman, B.T. (2002) A mutant epidermal growth factor receptor targeted to lung epithelium inhibits asbestos-induced proliferation and proto-oncogene expression. Cancer Res. 62, 4169-4175.

 

Cummins, A.B., Palmer, C., Mossman, B.T., and Taatjes, D.J. (2003) Persistent localization of activated extracellular signal-regulated kinases (ERK1/2) is epithelial cell-specific in an inhalation model of asbestosis. Am. J. Pathol. 162, 713-720.

 

  BeruBe, K., Quinlan, T., Mossman, B., and Taatjes, D (1998) Diverse microscopy imaging techniques for studies of asbestos-induced lung disease. Microscopy and Analysis 29, 13-15.

 

Taatjes, D.J., Palmer, C.J., Pantano, C., Buder-Hoffmann, S., Cummins, A., and Mossman, B.T. (2001) Laser-based microscopic approaches: Application to cell signaling in environmental lung disease. BioTechniques 31(4), 880-895.

 

 

CORY TEUSCHER

 

Teuscher, C., Rhein, D.M., Livingstone, K.D., Paynter, R.A., Doerge, R.W., Nicholson, S.M., and Melvold, R.W.  (1997). Evidence that Tmevd2 and eae3 May Represent Either a Common Locus or Members of a Gene Complex Controlling Susceptibility to Immunologically Mediated Demyelination in Mice.  J. Immunol.  159:4930-4934.

 

Snoek, M., Teuscher, C., and van Vugt, H.  (1998). Molecular Analysis of the Major MHC Recombinational Hot Spot Located Within the G7c Gene of the Murine Class III Region that is Involved in Disease Susceptibility.  J. Immunol.  160:266.

 

Roper, R. J., Call, S. B., Tung, K. S. K., Hickey, W. F., Doerge, R. A., and Teuscher, C.  (1998). Murine Autoimmune Orchitis, Epididymitis, and Vasitis are Immunogenetically Distinct Clinical Entities.  Am. J. Pathol.  152:1337-1345.

 

Teuscher, C., Hickey, W. F., Grafer, C. M., and Tung, K. S. K.  (1998). A Common Immunoregulatory Locus Controls Susceptibility to Actively Induced Experimental Allergic Encephalomyelitis and Experimental Allergic Orchitis in BALB/c Mice.  J. Immunol.  160:2751-2756.

 

Butterfield, R. J., Sudweeks, J. D., Blankenhorn, E. P., Korngold, R., Marini, J. C., Todd, J. A., Roper, R. A., and Teuscher, C.T.  (1998).  New Genetic Loci that Control Susceptibility and Clinical Symptoms of Experimental Allergic Encephalomyelitis.  J. Immunol.  161:1860-1867.

 

Butterfield, R. J., Blankenhorn, E. P., Roper, R. J., Zachary, J. F., Doerge, R. W., Sudweeks, J., Rose, J., and Teuscher, C.  (1998) Genetic Analysis of Disease Subtypes and Sexual Dimorphisms in Mouse EAE: Relapsing-Remitting and Monophasic Remitting/Non-Relapsing EAE are Immunogenetically Distinct.  J. Immunol. 161:1860-1867. 

 

Roper, R. J., Griffith, J. S., Lyttle, C. R., Doerge, R. W., McNabb, A. W., Broadbent, R. E., and Teuscher, C.  (1998) Interacting Quantitative Trait Loci Control Phenotypic Variation in Murine Estradiol-Regulated Responses.  Endocrinology 140:556-561.

 

Weis, J. J., McCracken, B. A., Ma, Y., Fairbairn, D., Weis, J., Roper, R. J., Zachary, J. F., Doerge, R. W. and Teuscher, C.  (1999) Identification of Quantitative Trait Loci Governing Arthritis Severity and Humoral Response in the Murine Model of Lyme Disease.  J. Immunol.  162:948-956.

 

Encinas, J.A., Wicker, L.S., Peterson, L.P., Mukasa, A., Teuscher, C., Sobel, R., Seidman, C.E., and Kuchroo, V.K.  (1999) Colocalization of QTL Influencing Both Autoimmune Diabetes and Autoimmune Encephalomyelitis to a 0.15 cM Region on Mouse Chromosome 3.  Nature Genetics 21:158-160.

 

Butterfield, R.J., Blankenhorn, E.P., Roper, R.J., Zachary, J.F., Doerge, R.W., Sudweeks, J., Rose, J., and Teuscher, C.  (1999) Genetic Analysis of Disease Subtypes and Sexual Dimorphisms in Mouse EAE: Relapsing-Remitting and Monophasic Remitting/Non-relapsing EAE are Immunogenetically Distinct.  J. Immunol. 162:3096-3102.

 

Meeker, N.D., Stafford, A., Avner, P., Lunceford, J.K., Ma, R., and Teuscher, C.  (1999)  Physical Mapping of the Autoimmune Disease Susceptibility Locus, Bphs: Co-localization with a Cluster of Genes from the TNF Receptor Superfamily on Mouse Chromosome 6.  Mamm. Genome 10:858-863.

 

Teuscher, C., Butterfield, R. J., Ma, R. Z., Zachary, J. F., Doerge, R. W., and Blankenhorn, E. P.  (1999) The Chemokines scya1 (TCA-3), scya2 (MCP-1), and scya12 (MCP-5) are Candidate Genes for eae7, an EAE-Modifying Locus Associated with the Severity of Clinical Signs.  J. Immunol.  163: 2262-2266.

 

Blankenhorn, E. P. Butterfield, R. J., Rigby, R., Cort, L., Giambrone, D, McDermott, P., McEntee, K., Solowiski, N., Meeker, N. D., Zachary, J. F., Doerge, R. W., and Teuscher, C.  1999.  Genetic Analysis of the Influence of Pertussis Toxin on EAE Susceptibility:  An Environmental Agent can Override Genetic Checkpoints.  J. Immunol. 164:3420-3425.

 

Brown, J. P., Zachary, J. F., Teuscher, C., Weis, J., and Wooten, R. M.  1999.  Dual Role of IL-10 in Murine Lyme Disease: Regulation of Arthritis Severity and Host Defense.  Infect. Immun. 67:5142-5150.

 

Butterfield, R. J., Blankenhorn, E. P., Roper, R. J., Zachary, J. F., Doerge, R. W., and Teuscher, C.  (2000) Identification of Genetic Loci Controlling the Characteristics and Severity of Brain and Spinal Cord Lesions in Experimental Allergic Encephalomyelitis.  Am. J. Pathol. 157:637-645.

 

Ma, R. A., Gao, J., Meeker, N. D., Fillmore, P. D., Tung, K. S. K., Watanabe, T., Zachary, J. F., Offner, H., Blankenhorn, E. P. and Teuscher, C.  2002.  Identification of Bphs, an Autoimmune Disease Locus, as Histamine Receptor H1.  Science 297:620-623.

 

Roper, R. R., Ma, R. A., Biggins, J. E., Butterfield, R. J., Michael, S. D., Tung, K. S. K., Doerge, R. W., and Teuscher, C.  2002.  Interacting Quantitative Trair Loci Control Loss of Peripheral Tolerance and Susceptibility to Autoimmune Ovarian Dysgenesis after Day 3 Thymectomy in Mice.  J. Immunol. 169:1640-1646. 

 

 

 

 

 

ALBERT VAN DER VLIET

 

van der Vliet A, Hoen PA, Wong PS, Bast A, Cross CE.:  Formation of S-nitrosothiols via direct nucleophilic nitrosation of thiols by peroxynitrite with elimination of hydrogen peroxide. J Biol Chem. 273:30255-30262, 1998.

 

van Der Vliet A, Nguyen MN, Shigenaga MK, Eiserich JP, Marelich GP, Cross CE.: Myeloperoxidase and protein oxidation in cystic fibrosis.  Am J Physiol Lung Cell Mol Physiol. 279:L537-L546, 2000.

 

Reddy S, Jones AD, Cross CE, Wong PS, Van Der Vliet A.: Inactivation of creatine kinase by S-glutathionylation of the active-site cysteine residue.  Biochem J. 347(Pt 3):821-827, 2000

 

Okamoto T, Akaike T, Sawa T, Miyamoto Y, van der Vliet A, Maeda H.: Activation of matrix metalloproteinases by peroxynitrite-induced protein S-glutathiolation via disulfide S-oxide formation.  J Biol Chem. 276:29596-29602, 2001.

 

Nguyen H, Finkelstein E, Reznick A, Cross C, van der Vliet A.:Cigarette smoke impairs neutrophil respiratory burst activation by aldehyde-induced thiol modifications.Toxicology.160:207-217, 2001.

 

Finkelstein EI, Nardini M, van der Vliet A.:  Inhibition of neutrophil apoptosis by acrolein: a mechanism of tobacco-related lung disease? Am J Physiol Lung Cell Mol Physiol. 281:L732-L739, 2001.

Wong PS, Eiserich JP, Lopez CL, Jones AD, Reddy S, Cross CE and van der Vliet A:  Inactivation of glutathione S-transferase by nitric oxide-derived oxidants.  Exploring a role for tyrosine nitration.  Arch Biochem Biophys 394:216-228, 2001.

 

Nardini M, Finkelstein EI, Reddy S, Valacchi G, Traber M, Cross CE, and van der Vliet A: Acrolein-induced cytotoxicity in cultured human bronchial epithelial cells. Modulation by alpha-tocopherol and ascorbic acid. Toxicology 170: 173-185, 2002.

 

Kenyon NJ, van der Vliet A, Schock BC, Okamoto T, McGrew GM, and Last JA: Susceptibility to ozone-induced acute lung injury in iNOS-deficient mice. Am J Physiol 282:L540-L545, 2002.

 

Banerjee T, van der Vliet A, and Ziboh VA: Downregulation of COX-2 and iNOS by amentoflavone and quercetin in A549 human lung epithelial cell line. Prostaglandins, Leukotrienes, and Essential Fatty Acids 66:485-492, 2002.

 

Valacchi G, van der Vliet A, Schock BC, Okamoto T, Obermuller-Jevic U, Cross CE, and Packer L: Ozone exposure activates oxidative stress responses in murine skin. Toxicology 179:163-170, 2002.

 

Okamoto T, Valacchi G, Gohil K, Akaike T, and van der Vliet A: S-Nitrosothiols inhibit cytokine-mediated induction of MMP-9 in airway epithelial cells. Am J Respir Cell Mol Biol 27:463-473, 2002.

 

Reddy S, Finkelstein EI, Wong PS, Phung A, Cross CE, and van der Vliet A: Identification of glutathione modifications by cigarette smoke. Free Rad Biol Med 33: 1490-1498, 2002.