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Unlocking the mysteries of drug actions, discovering new therapies, and developing new medicinal products.
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Alan K. Howe, Ph.D.
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Associate Professor |
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Department of Pharmacology
322 HSRF Building
149 Beaumont Avenue
Burlington, VT 05405
Phone: (802) 656-9521
Fax: (802) 656-4523 |
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Alan.Howe@uvm.edu
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Education
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Ph.D. Northwestern University, Evanston IL 09/1996 Tumor Cell Biology
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B.S. University of New Hampshire, Durham NH 06/1990 Biochemistry
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Positions Held
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Associate Professor, University of Vermont 07/01/09 - present
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Assistant Professor, University of Vermont 08/01/03 - 06/30/09
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Research Assistant Professor, University of North Carolina 08/01/01 - 07/31/03
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Postdoctoral Research Assistant, University of North Carolina 09/01/96 - 07/31/01
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Professional Societies
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American Society for Biochemistry Membership pending
and Molecular Biology
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American Society for Cell Biology Regular Member 1996-Present
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American Society for Virology Student Member 1994-1996
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Membership
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2004 Co-chair, Vermont Cancer Center Symposium
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2003-Present Member, Cell & Molec. Biology Program Education Committee
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2003-Present Member, Cell & Molecular Biology Program Faculty
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2003-Present Member, Graduate Faculty, University of Vermont
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2003-Present Full Member, Vermont Cancer Center
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2000-Present Ad hoc reviewer: Cell, Cell Motil. Cytoskeleton, J. Biol. Chem.,
J. Cell Biol., J. Cell Sci., Oncogene
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2002-2003 Planning Committee, UNC Pharmacology Postdoctoral Research
Seminar Series
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1997-1999 Lineberger Comprehensive Cancer Center Postdoctoral Affairs Committee
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Teaching Experience
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2004 Co-presenter (c/T. Morielli), MD/PhD Lecture Series
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2004 Lecturer, UVM PHCO 290 “Cell Adhesion & Cytoskeletal Dynamics”
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2004 Lecturer, UVM CMB 301/302 “Extracellular Matrix & Cell Polarity”
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2002 Course Instructor (Adhesion Receptor Signaling in Cancer &
Cardiovascular Disease)
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1999-2002 Teaching Assistant (Adhesion Receptors & Cell Growth; Super Cell
Biology), UNC Chapel Hill
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1993 Teaching Assistant (Medical Microbiology), Northwestern University
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1988-1990 Teaching Assistant (Biochemistry; Nutritional Biochemistry), U. New Hampshire
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Awards and Honors
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2003 Invited Speaker, Albany Medical College, Albany NY
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2002 Invited Speaker, American Society for Cell Biology Meeting, San
Francisco
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2002 Invited Panelist, UNC Postdoctoral Association Symposium - ‘Grant
Writing for Success’
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2002 Invited Scientific Speaker, American Cancer Society/UNC Relay For Life
Kick-off Event
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2001 Recipient, Howard Temin Career Award (NCI)
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1999-2001 Invited Speaker, Lineberger Cancer Center Postdoctoral Research
Symposium
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1999-2001 Postdoctoral fellow, American Cancer Society
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1999 UNC-CH Nominee, Burroughs Wellcome Fund Career Award in the
Biomedical Sciences
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1999 Invited Speaker, American Society for Cell Biology Meeting, Washington,
D.C.
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1999 Invited Speaker, 5th Annual International Dahlem Symposium: Cellular Signal Recognition and Transduction, Berlin, Germany
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1997 Invited Speaker, Symposium on Integrins in Motility, Invasion, and Signal
Transduction, UNC School of Dentistry
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1996 Fellow, Lineberger Comprehensive Cancer Center Postdoctoral Training
Award
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1994-1995 Graduate fellow, Ingberman Charitable Trust
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1994 Invited Speaker, Children’s Memorial Research Institute, Sydney,
Australia
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1993-1994 Graduate Trainee, Cell and Molecular Basis of Disease NRSA (to
Northwestern Univ.)
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1991-1992 Graduate Fellow, Chicago Baseball Cancer Charities, Northwestern Univ.
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1990 Graduate Fellow, Carcinogenesis Training Grant, Northwestern Univ.
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1990 Graduated cum laude, Univ. New Hampshire
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Publications
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1. Goswami, R., Turk, B., Enderle, K., Howe, A., and Rundell, K.. 1992. Effect of zinc ions on the biochemical behavior of simian virus 40 small-t antigen expressed in bacteria. J. Virol. 66:1746-1751.
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2. Watanabe*, G., Howe*, A., Lee, R.J., Albanese, C., Shu, I.W., Karnezis, A.N., Zon, L., Kyriakis, J., Rundell, K., and Pestell, R.G.. 1996. Induction of cyclin D1 by simian virus 40 small tumor antigen. Proc. Nat. Acad. Sci. USA 93:12861-12866. ( * contributed equally to this manuscript)
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3. Porras, A., Bennett, J., Howe, A., Tokos, K., Bouck, N., Henglein, B., Sathyamangalam, S., Thimmapaya, B., and Rundell, K.. 1996. A novel simian virus 40 early-region domain mediates transactivation of the cyclin A promoter by small-t antigen and is requied for transformation in small-t antigen-dependent assays. J. Virol. 70:6902-6908.
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4. Lin, T., Chen, Q., Howe, A., and Juliano, R.. 1997. Cell anchorage permits efficient mitogenic signaling between Ras and its downstream kinases. J. Biol. Chem. 272:8849-8852.
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5. Howe, A. and Juliano, R.L.. 1998. Distinct mechanisms mediate the initial and sustained phases of integrin-mediated activation of the Raf/MEK/mitogen-activated protein kinase cascade. J. Biol. Chem. 273:27268-27274.
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6. Howe, A., Gaillard, S., Bennett, J.S., and Rundell, K.. 1998. Cell cycle progression in monkey cells expressing simian virus 40 small t antigen from adenovirus vectors. J. Virol. 72:9637-9644.
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7. Howe, A., Aplin, A.E., Alahari, S. and Juliano, R.L.. 1998. Integrin signaling and cell growth control. Curr. Opin. Cell Biol. 10:220-231.
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8. Aplin, A.E., Howe, A., Alahari, S. and Juliano, R.L.. 1998. Signal transduction from cell adhesion receptors - the role of integrins, cadherins, selectins, and Ig-CAMs. Pharm. Rev. 50:197-263.
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9. Juliano, R.L., Aplin, A.E., Howe, A.K., Lin, T., and Chen, Q. 1999. Methods for study of integrin regulation of MAP kinase signaling cascades. In Signaling Through Cell Adhesion Molecules (J.-L. Guan, ed), pp117-128, CRC Press, Boca Raton.
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10. Aplin, A., Howe, A.K., and Juliano, R.L.. 1999. Cell adhesion molecules, signal transduction, and cell cycling. Curr. Opin. Cell. Biol. 11:737-744.
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11. Howe, A.K. and Juliano, R.L.. 2000. Regulation of anchorage-dependent signal transduction by protein kinase A and p21-activated kinase. Nature Cell Biol. 2:593-600.
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12. Juliano, R.L., Aplin, A.E., Howe, A.K., Short, S., Lee, J.W., and Alahari, S.. 2001. Integrin regulation of receptor tyrosine kinase and G protein-coupled receptor signaling to mitogen-activated protein kinases. Meth. Enzymol. 333:151-63.
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13. Edin, M., Howe, A.K., and Juliano, R.L.. 2001. Inhibition of PKA negatively regulates fibroblast motility. Exp. Cell Res. 270:214-222.
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14. Howe, A.K.. 2001. Cell adhesion regulates the interaction between Nck and p21-activated kinase. J. Biol. Chem. 276:14541-14544.
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15. Howe, A.K., Aplin, A.E., and Juliano, R.L.. 2002. Anchorage-dependent ERK signaling - mechanisms and consequences. Curr. Opin. Genet. Dev. 12:30-35.
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16. Howe, A. K., Hogan, B.P., and Juliano, R.L.. 2002. Regulation of vasodilator-stimulated phosphoprotein phosphorylation and interaction with Abl by protein kinase A and cell adhesion. J. Biol. Chem. 277: 38121-38126
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17. Goldfinger, L.E., Han, J., Kiosses, W.B., Howe, A.K., and Ginsberg, M.H.. 2003. Spatial restriction of a 4 integrin phosphorylation regulates lamellipodial stability and alpha4beta1-dependent cell migration. J Cell Biol. 162(4):731-41.
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18. Howe, A.K. 2004. Regulation of actin-based cell migration by cAMP and PKA (Review). Biochim Biophys Acta. 1692(2-3):159-74.
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Abstracts
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1. Howe, A. K., Lin, T., and Juliano, R.. The role of integrin-mediated cell adhesion in regulating Raf-1 activation. Keystone Symp. - Signal Transduction by Cell Adhesion Receptors, Keystone, CO, Apr., 1997
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2. Howe, A. K. and Juliano, R.L.. Regulation of Raf activity by integrin-mediated cell adhesion. Amer. Soc. Cell Biol., Washington, D.C., Dec. 1997.
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3. Howe, A. K. and Juliano, R.L.. Distinct phases in integrin-mediated Raf activation. Amer. Soc. Cell Biol., San Francisco, CA, Dec. 1998.
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4. Howe, A. K. and Juliano, R.L.. Regulation of anchorage-dependent signal transduction by PKA and PAK. Amer. Soc. Cell Biol., Washington D.C., Dec. 1999. (selected for mini-symposium presentation)
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5. Howe, A. K. and Juliano, R.L.. Regulation of anchorage-dependent signaling by the cAMP-dependent protein kinase and p21-activated protein kinase. Keystone Symp.- Joint Regulation of Signaling Pathways by Integrins and Growth Factors, Breckenridge, CO, Mar. 2000.
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6. Howe, A. K. and Juliano, R.L.. Regulation of anchorage-dependent signaling by the cAMP-dependent protein kinase and p21-activated protein kinase. Gordon Conf. – Signaling by Cell Adhesion Receptors, Newport RI, July 2000.
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7. Howe, A. K. and Juliano, R.L.. PKA mediates adhesion-dependent phosphorylation and protein-protein interactions of VASP family members. Amer. Soc. Cell Biol., Washington D.C., Dec.2001
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8. Howe, A. K. Protein kinase A activity and anchoring are required for pseudopod extension during chemotaxis. Amer. Soc. Cell Biol., San Francisco CA, Dec. 2002
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9. Howe, A. K. and Juliano, R. L.. Regulation of Vasodilator-Stimulated Phosphoprotein Phosphorylation and Interaction with Abl by Protein Kinase A and Cell Adhesion. Amer. Soc. Cell Biol., San Francisco CA, Dec. 2002 (selected for mini-symposium presentation)
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10. Howe, A. K.. Protein kinase A activity and anchoring are required for pseudopod extension during chemotaxis. Vermont Genetics Network Symposium, Burlington VT Sept. 2003
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Presentations
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09/05/2003 Annual Cell & Molecular Biology Program Retreat, Univ. of Vermont – “Protein kinase A signaling in cell migration – Down the 3-micron rabbit hole”
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10/14/2003 Albany Medical College – “Protein kinase A in cytoskeletal regulation – VASP, Abl, and 3-micron rabbit holes”
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11/06/2003 UVM Department of Pharmacology Annual Retreat – “Phosphoproteomics? I thought he worked on cell adhesion?”
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12/01/2003 UVM Department of Molecular Physiology & Biophysics – “Cytoskeletal regulation by protein kinase A – VASP, Abl, and 3-micron rabbit holes”
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12/10/2003 Lake Champlain Cancer Research Organization Board Meeting – “Two Renaissance painters, Lewis Carroll, and cancer metastasis – Everything in context”
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01/12/2004 UVM Cell Signaling & Environmental Pathology Seminar Series – “Spatial regulation of protein kinase A during cell migration”
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03/02/2004 Vermont Cancer Center Grand Rounds – “Spatial Regulation of Signal Transduction During Cell Migration”
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04/12/2004 UVM Department of Biology – “Protein Kinase A in Adhesive & Cytoskeletal Signaling”
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Link to Dr. Howe's Publications
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