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Unlocking the mysteries of drug actions, discovering new therapies, and developing new medicinal products.
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Joseph E. Brayden, Ph.D.
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Department of Pharmacology
B-303 Given Building
89 Beaumont Avenue
Burlington, VT 05405
Phone: (802) 656-1985
Fax: (802) 656-4523 |
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Joe.Brayden@uvm.edu
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Education
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1973 B.S. (Biology) - Union College, Schenectady, N.Y.
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1982 Ph.D. (Physiology & Biophysics) - University of Vermont, College of Medicine
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Professional Positions
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7/96 - present Professor, Department of Pharmacology, University of Vermont
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7/92 - 6/96 Associate Professor, Department of Pharmacology, University of Vermont
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2/86 - 6/92 Assistant Professor, Department of Pharmacology, University of Vermont
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5/85 - 11/85 Research Fellow, Department of Pharmacology, St. George's Hospital Medical School, London
Supervisor: Dr. Tom Bolton
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7/83 - 5/85 NIH Postdoctoral Fellow, Department of Pharmacology, University of Vermont
Supervisor: Dr. John Bevan
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9/82 - 7/83 American Heart Association Postdoctoral Fellow, Department of Pharmacology, UCLA School of Medicine Supervisor: Dr. John Bevan
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1978 - 1982 Graduate Teaching Assistant, Department of Physiology & Biophysics, University of Vermont
Thesis Advisor: Dr. William Halpern
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1977 - 1978 Research Technologist, Department of Physiology & Biophysics, University of Vermont
Supervisor: Dr. Robert B. Low
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1974 - 1977 Research Technologist, Department of Physiology & Biophysics, University of Vermont
Supervisor: Dr. Norman R. Alpert
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Awards and Honors
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National Science Foundation Summer Fellowship, Brown University, 1968
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New York State Regents Scholarship, 1969-1973
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Clark Foundation Scholarship (full undergraduate tuition and fees), 1969-1973
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Cum Laude graduate, Union College, 1973
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PHS NRSA Postdoctoral Fellowship, 1983-1985
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PHS NIH New Investigator Award, 1986-1989
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Established Investigator of the American Heart Association, 1990-1995
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Member of the Experimental Cardiovascular Sciences study section (Division of Research Grants, NIH), 1992 to 1996.
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Publications
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Reading SA, Earley S, Waldron BJ, Welsh DG, Brayden JE. TRPC3 Mediates Pyrimidine Receptor-induced Depolarization of Cerebral Artery. Am J Physiol Heart Circ Physiol. 2004 Dec 16; [Epub ahead of print]
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Earley S, Waldron BJ, Brayden JE. Critical role for transient receptor potential channel TRPM4 in myogenic constriction of cerebral arteries. Circ Res. 2004 Oct 29;95(9):922-9.
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Babu GJ, Pyne GJ, Zhou Y, Okwuchukuasanya C, Brayden JE, Osol G, Paul RJ, Low RB, Periasamy M. (2004) Isoform switching from SM-B to SM-A myosin results in decreased contractility and altered expression of thin-filament/regulatory proteins. Am J Physiol Cell Physiol. 287(3):C723-C729.
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Taylor, M.S., Okwuchukwuasanya, C., Nickl, C.K., Tegge, W.J., Brayden, J.E., Dostmann, W.R.G. (2004). Inhibition of cGMP-dependent protein kinase by the cell-permeable peptide DT-2 reveals a novel mechanism of vasoregulation. Molecular Pharmacology 65 (5): 1111-9.
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Taylor M.S., Bonev A.D., Gross T.P., Eckman D.M., Brayden J.E., Bond C.T., Adelman J.P., Nelson M.T. (2003). Altered expression of small-conductance Ca2+-activated K+ (SK3) channels modulates arterial tone and blood pressure. Circ Res. 93:124-131.
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Osol, G, Brayden J (2002) Prologue: vascular myogenic mechanisms. Am. J. Physiol. 282:H2157-H2159.
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Slish D.F., Welsh D.G., Brayden J.E. (2002) Diacylglycerol and protein kinase C activate cation channels involved in myogenic tone. Am J Physiol 283:H2196-2201.
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Brayden, J.E. (2002) Functional roles of KATP channels in vascular smooth muscle. Clin. Exp. Pharmacol. Physiol. 29(4):312-6
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Dostmann, W.R., Tegge, W.J., Nickl, C.K., Taylor, M.S., and Brayden, J.E. (2002) Exploring the mechanisms of vascular smooth muscle tone with highly specific, membrane permeable inhibitors of cGMP-dependent protein kinase Ia. Pharmacology & Therapeutics;93(2-3):203-15.
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Teng G.Q., Nauli S.M., Brayden J.E., Pearce W.J. (2002) Maturation alters the contribution of ptassium channels to resting and 5HT-induced tone in small cerebral arteries of the sheep. Brain Res Dev Brain Res 133 (2):81-91.
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Welsh, D.G., Morielli, A.D., Nelson, M.T. and Brayden, J.E. (2002) Transient receptor potential channels regulate myogenic tone of resistance arteries. Circulation Research 90:248-250
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Dostmann, W.R.G., Nickl, C.K, Taylor M.S., Brayden J.E., Frank R. and Tegge, W.J. (2001) Highly specific and membrane permeant peptide inhibitors of cGMP-dependent protein kinase Ia. Cell. Biol. Mol. Lett., 6:458.
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Welsh, D.G. and Brayden, J.E. (2001) Mechanisms of coronary artery depolarization by uridine triphosphate. Am J Physiol 280:H2545-H2553.
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Book Chapters
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Brayden, J.E. (2001) Physiological role of K+ channels in the regulation of vascular tone. In: Potassium channels in cardiovascular biology, S.L. Archer, N.J. Rusch, Eds. (Kluwer Academic/Plenum Publishers) pp.443-455.
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Brayden, J.E., Bonev, A., Lounsbury, K., Knot, H., Wellman, G.C. and Nelson, M.T. (2000) Potential cardioprotective effects of estrogen involving ion channels, endothelium, and coronary artery reactivity. In: Biology of Menopuase, F.L. Bellino, Ed. (Springer-Verlag, New York, Inc.) pp. 181-188.
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Brayden, J.E. and Murphy, M.A. (1996) Potassium channels activated by endothelium-derived factors in mesenteric and cerebral resistance arteries. In Endothelium-derived Hyperpolarizing Factor, P.M. Vanhoutte, Ed. (Harwood Academic Publishers) pp. 137-142.
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Knot, H.J, Brayden, J.E., and Nelson, M.T. (1996) Calcium channels and potassium channels in smooth muscle. In Biochemistry of Smooth Muscle Contraction, M. Barany, Ed. (Academic Press) pp. 203-217
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Wellman, G.C., Brayden, J.E., and Nelson, M.T. (in press) Proposed mechanism for the cardioprotective effect of estrogen in women: enhanced endothelial nitric oxide release decreases coronary artery reactivity. Clinical and Experimental Pharmacology and Physiology
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Link to Dr. Brayden's Publications
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