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Unlocking the mysteries of drug actions, discovering new therapies, and developing new medicinal products.
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Mark T. Nelson, Ph.D.
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Professor and Chairman |
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Department of Pharmacology
The University of Vermont, College of Medicine
Given Building, Room B-333
89 Beaumont Avenue
Burlington, VT 05405-0068
Phone: (802)-656-2500
Fax: (802)-656-4523 |
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Education
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1980 Ph.D., Neural Sciences Washington University, St. Louis, MO
Advisor: Prof. M.P. Blaustein
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1976 B.A., Mathematics & Biology with Honors Tufts University, Medford, MA
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1973 Undergraduate studies Swarthmore College, Swarthmore, PA
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Positions Held
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6/96- Chair, Department of Pharmacology, College of Medicine, University of Vermont, Burlington, VT
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7/95-5/96 Interim Chair, Department of Pharmacology, University of Vermont
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5/93- Professor, Department of Molecular Physiology & Biophysics, University of Vermont (Secondary)
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7/92- Professor, Department of Pharmacology, College of Medicine, University of Vermont
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7/90-6/92 Associate Professor with Tenure, Department of Pharmacology, University of Vermont
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6/86-6/90 Assistant Professor, Department of Pharmacology, University of Vermont
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9/84-5/86 Assistant Professor, Department of Pharmacology, University of Miami School of Medicine, Miami, FL
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11/82-8/84 Research Assistant Professor, Department of Physiology, University of Maryland School of Medicine, Baltimore, MD. Sponsor: Professor B.K. Krueger
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6/81-10/82 Research Fellow of the Alexander von Humboldt Stiftung, Fakultät für Biologie, Universität Konstanz, West Germany. Sponsor: Professor P. Läuger
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4/80-5/81 Research Fellow of the American Heart Association, Dept. of Physiology, University of Maryland, Baltimore, MD. Sponsor: Professor M.P. Blaustein
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Awards and Honors
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2009- University Distinguished Professor, University of Vermont
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2009- Fellow, Biophysical Society
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2008-2018 MERIT Award, NIH
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2001- Fellow, American Heart Association and the Council on Basic Cardiovascular Sciences
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1998- Vermont Academy of Sciences and Engineering, member
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1996 University Scholar, University of Vermont
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1985 - 1990 Established Investigator of the American Heart Association
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1982 Louis N. Katz Research Prize for Young Investigators, Honorable Mention (AHA)
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1981-1982, 1984 Alexander von Humboldt-Stiftung Fellowship, Universität Konstanz, West Germany
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1980-1981 American Heart Association Fellowship, University of Maryland
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1978-1980 National Institutes of Health Predoctoral Fellowship, Washington University
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1974 National Science Foundation Summer Fellowship, Swarthmore College
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Publications
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Top Cited Papers (1988 - 2008), as of May 12, 2009.
For comparison, the total number of citations of individual articles published in the American Journal of Physiology, Circulation Research and similar journals, over a period of 7 years (1987-1993), averaged about 8 [range: 4 (Cardiovascular Research) to 19 (J. Biol. Chem.)] (The Physiologist 38:84, 1995).
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Number
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Citations Article
1138 1989 Science 245:177-180 Standen, N.B., Quayle, J.M., Davies, N.W., Brayden, J.E., Huang, Y., and Nelson, M.T. Hyperpolarizing vasodilators activate ATP-sensitive K+ channels in arterial smooth muscle.
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478 1990 American Journal of Physiology, Cell Physiology 259:C3-C18 Nelson, M.T., Patlak, J.B., Worley, J.F., and Standen, N.B. Calcium channels, potassium channels and the voltage-dependence of arterial smooth muscle tone.
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680 1995 Science 270:633-637 (With a Perspective from Dr. F. Fay) Nelson, M.T., Cheng, H.P., Rubart, M., Santana, L.F., Bonev, A., Knot, H., and Lederer, W.J. Relaxation of arterial smooth muscle by calcium sparks.
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562 1992 Science 256:532-535 Brayden, J.E. and Nelson, M.T. Regulation of arterial tone by activation of calcium-dependent potassium channels.
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434 1995 American Journal of Physiology, Cell Physiology 268:C799-C822 Nelson, M.T. and Quayle, J.M. Physiological roles and properties of potassium channels in arterial smooth muscle.
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369 1993 American Journal of Physiology, Cell Physiology 265:C299-C303 Robertson, B., Schubert, R., Hescheler, J., and Nelson, M.T. Cyclic-GMP-dependent protein kinase activates calcium-activated potassium channels in cerebral artery smooth muscle cells.
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363 1990 Nature 344:770-773 Nelson, M.T., Huang, Y., Brayden, J.E., Hescheler, J.K., and Standen, N.B. Arterial dilations in response to calcitonin gene-related peptide involve activation of K+ channels.
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399 1997 Physiological Reviews 77:1165-1232 Quayle, J.M., Nelson, M.T., and Standen, N.B. ATP-sensitive and inwardly rectifying potassium channels in smooth muscle.
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279 1988 Nature 336:382-385 Nelson, M.T., Standen, N.B., Brayden, J.E., and Worley, J.F. Noradrenaline contracts arteries by activating voltage-dependent calcium channels.
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176 2000 American Journal of Physiology, Cell Physiology 278(2):C235-C256 Jaggar, J.H., Porter, V.A., Lederer, W.J. and Nelson, M. Calcium sparks in smooth muscle.
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159 1991 American Journal of Physiology, Heart and Circulatory Physiology 260:H927-H934 Langton, P.D., Huang, Y., Nelson, M.T., and Standen, N.B. Block of Ca2+-activated K+ channels in mammalian arterial myocytes by tetraethylammonium ions.
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152 1994 Journal of Physiology 475:9-13 Quayle, J.M., Bonev, A., Brayden, J.E., and Nelson, M.T. Calcitonin gene-related peptide activates ATP-sensitive K+ channels in rabbit arteries via protein kinase A.
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129 1988 Nature 334:703-705 Zschauer, A., Van Breemen, C. Buhler, F. R., and Nelson, M.T., Calcium channels in thrombin activated human platelet membranes incorporated into planar phospholipids bilayers.
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252 2000 Nature, 407(6806):870-876 Brenner, R., Perez, G.J., Bonev, A.D., Eckman, D.M., Kosek, J.C., Wiler, S.W., Patterson, A.J., Nelson, M.T. and Aldrich, R.W. Vasoregulation by the beta 1 subunit of the calcium- activated potassium channel.
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211 1998 Journal of Physiology-London, 508(1): 199-209 Knot H.J. and Nelson, M.T. Regulation of arterial diameter and wall [Ca2+] in cerebral arteries of rat by membrane potential and intravascular pressure.
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154 1996 Circulation Research 79(5): 1024-1030 Wellman, G.C., Bonev, A.D., Nelson, M.T. and Brayden, J.E. Gender differences in coronary artery diameter involve estrogen, nitric oxide, and Ca2+-dependent K+ channels.
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155 1993 American Journal of Physiology, Cell Physiology 265:C1363-C1370 Quayle, J.M., McCarron, J., Brayden, J., and Nelson, M.T. Inward rectifier potassium currents in smooth muscle cells from rat resistance-sized cerebral arteries.
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111 1986 National Academy of Sciences 83(15): 5746-5750 Worley, J.F., Deitmer, J.W. and Nelson, M.T. Single nisoldipine-sensitive calcium channels in Smooth-muscle cells isolated from rabbit mesenteric-artery.
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148 1995 American Journal of Physiology, 269 (1):H348-H355 Knot, H.J. and Nelson, M.T. Regulation of membrane-potential and diameter by voltage- dependent K+ channels in rabbit myogenic cerebral-arteries.
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146 1996 Journal of Physiology-London,492(2): 419-430 Knot, H.J., Zimmerman, P.A. and Nelson, M.T. Extracellular K+-induced hyperpolarizations and dilatations of rat coronary and cerebral arteries involve inward rectifier K+ channels.
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110 1993 Trends in Cardiovascular Medicine 3:54-60 Nelson, M.T. Ca2+-activated potassium channels and ATP-sensitive potassium channels as modulators of vascular tone.
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105 1993 American Journal of Physiology, 264 (5):C1190-C1200 Bonev, A.D. and Nelson, M.T. ATP-sensitive potassium channels in smooth-muscle cells from guinea-pig urinary-bladder
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114 1997 Journal of Physiology-London, 502 (2):259-264 Nelson, M.T., Conway, M.A., Knot, H.J. and Brayden, J.E. Chloride channel blockers inhibit myogenic tone in rat cerebral arteries.
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133 1999 Journal of General Physiology, 113 (2):229-237 Perez, G.J., Bonev, A.D., Patlak, J.B. and Nelson, M.T. Functional coupling of ryanodine receptors to K-Ca channels in smooth muscle cells from rat cerebral arteries.
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110 1998 Journal of Physiology-London, 508 (1):211-221 Knot, H.J., Standen, N.B. and Nelson, M.T. Ryanodine receptors regulate arterial diameter and wall [Ca2+] in cerebral arteries of rat via Ca2+-dependent K+ channels.
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81 1989 Journal of Physiology-London 412: 65-91 Nelson, M.T. and Worley, J.F. Dihydropyridine inhibition of single calcium channels and contraction in rabbit mesenteric-artery depends on voltage.
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80 1986 Journal of General Physiology, 87 (2):201-222 Nelson, M.T. Interactions of divalent-cations with single calcium channels from rat-brain Synaptosomes.
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112 1998 Acta Physiol. Scand. 164 (4): 577-78 Jaggar, J.H., Wellman, G.C., Heppner, T.J., Porter, V.A., Perez, G.J., Gollash, M., Kleppish, T., Rubart, M., Stevenson, A.S., Lederer, W.J., Knot, H.J., Bonev, A.D., Nelson, M.T. Ca2+ channels, ryanodine receptors and Ca2+ - activated K+ channels: a functional unit for regulating arterial tone.
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103 2000 Circulation Research 87 (2): 160-166 Zaritsky, J.J., Eckman, D.M., Wellman, G.C., Nelson, M.T. Targeted disruption of Kir2.1 and Kir2.2 genes reveals the essential role of the inwardly rectifying K+ current in K+ mediated vasodilation.
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87 1988 Journal of Biological Chemistry 263 (34): 18364-18368 Kovacs, R.J., Nelson, M.T., Simmerman, H.K.B. and Jones, L.R. Phospholamban forms Ca-2+-selective channels in lipid bilayers.
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101 1995 Proceedings of the National Academy of Sciences of the United States of America 92 (26): 12441-12445 Kleppisch, T. and Nelson, M.T. Adenosine activates ATP-sensitive potassium channels in arterial myocytes via A(2) receptors and cAMP-dependent protein kinase.
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79 1984 Nature 308: 77-80 Nelson, M.T., French, R.J., and Krueger, B.K. Voltage-dependent calcium channels from brain incorporated into planar lipid bilayers.
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146 2002 Circulation Research 90 (3): 248-250 Welsh, D.G., Morielli, A.D., Nelson, M.T. Transient receptor potential channels regulate myogenic tone of resistance arteries.
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ARTICLES (total of 168 peer reviewed articles)
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Petkov, G.V., Balemba, O.B., Nelson, M.T., and Mawe, G.M., Identification of a spontaneously active, Na+-permeable channel in guinea pig gallbladder smooth muscle. American Journal of Physiology- Gastrointestinal Liver Physiol. May 2005.
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Thorneloe, K.S. and Nelson, M.T., Ion channels in smooth muscle: regulators of intracellular calcium and contractility. Can.J. Physiol. Pharmacol. 83:215-242, April 2005.
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Gonzalez-Bosc, LV, Layne, J., Nelson, M.T, Hill-Eubanks, D. Nuclear factor of activated T-cells and serum response factor cooperatively regulate the activity of an a-actin intronic enhancer. Journal of Biological Chemistry, April 2005
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Thorneloe,K., Meredith AL, Knorn, A.M, Aldrich R.W. and Nelson, M.T. Urodynamic properties and neurotransmitter dependence of urinary bladder contractility in the BK channel deletion model of overactive bladder. American Journal of Physiology-Renal Physiology April 2005.
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Herrera, G.M., Etherton, B., Nausch, B., and Nelson, M.T. Negative feedback regulation of nerve-mediated contractions, American Journal of Physiology. April 2005.
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Petkov, G.V., and Nelson, M.T., Differential regulation of Ca2+-activated K+ (BK) channels by ß-adrenoreceptors in guinea pig urinary bladder smooth muscle. American Journal of Physiology-Cell Physiology. 288 (6): C1255-63, Jan. 2005.
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Heppner, T.J., Bonev, A.D., and Nelson, M.T., Elementary Purinergic Ca2+ transients evoked by nerve stimulation in rat urinary bladder smooth muscle. Journal of Physiology, 564pt 1): 201-12, April 2005
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Mokelke, E.A., Dietz, N.J., Eckman, D.M., Nelson, M.T. and Sturek, M., Diabetic Dyslipidemia and exercise affect coronary tone and differential regulation of conduit and microvessel K+ current. American Journal of Physiology-Heart, 288(3): H1233-41, March 2005.
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Heppner, T.J., Bonev, A.D., Eckman, D.M., Gomez, M.F., Petkov, G.V. and Nelson, M.T., Novel PPARgamma agonists GI 262570, GW 7845, GW 1929, and Pioglitazone decrease calcium channel function and myogenic tone in rat mesenteric arteries. Pharmacology, 73(1):15-22, January 2005
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Filosa, J.A., Bonev, A.D. and Nelson, M.T., Calcium dynamics in cortical Astrocytes and arterioles during neurovascular coupling. Circulation Research, 95(10):e73-81, Nov. 2004.
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Meredith, A.L., Thorneloe, K.S., Werner, M.E., Nelson, M.T., and Aldrich, R.W., Overactive bladder and incontinence in the absence of the BK large conductance Ca2+-activated K+ channel. Journal of Biological Chemistry 279(35):36746-36752, 2004.
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Hume, J.R. and Nelson, M.T., In Memoriam: Burton Horowitz. Circulation Research
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Heppner, T.J., Herrera, G.M., Bonev, A.D., Hill-Eubanks, D. and Nelson, M.T., Ca2+ sparks and K(Ca) channels: novel mechanisms to relax urinary bladder smooth muscle. Adv. Exp. Med. Biol. 539(Pt A): 347-57 2004.
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Nelson, M.T., and Bonev A.D., The beta (1) subunit of the Ca (2+)-sensitive K (+) channel protects against hypertension. Journal of Clinical Investigation; 113(7):955-7, April 2004.
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Etherton, B., Heppner, T.J. Cumming, J.R. and Nelson, M.T., Opposing effects of aluminum on inward-rectifier potassium currents in bean root-tip protoplasts. J. Membrane Biol.198(1):15-22, March 2004.
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Thorneloe, K. S. and Nelson, M.T, Properties of a tonically active, sodium-permeable current in mouse urinary bladder smooth muscle. Am J Physiol Cell Physiol. 2004 Jun;286(6):C1246-57
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Gonzalez Bosc, L.V., Wilkerson, M.K., Bradley KN, Eckman DM, Hill-Eubanks, D.C., and Nelson, M.T. Intraluminal pressure is a stimulus for NFATc3 nuclear accumulation: Role of calcium, endothelium-derived nitric oxide and cGMP-dependent protein-kinase. Journal of Biological Chemistry, 279(11):10702-10709, 2004.
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Li PL, Lee H.C., Nelson, M.T., Meininger GA, and Van Breemen C. Novel Ca2+ signaling mechanisms in vascular myocytes: symposium overview. Acta Physiol Scand, 179(4):339-52, 2003.
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Gomez, M.F., Gonzalez Bosc, L.V., Stevenson, A.S., Wilkerson, M.K., Hill-Eubanks, D.C., and Nelson, M.T. Constitutively elevated nuclear export activity opposes Ca2+-dependent NFATc3 nuclear accumulation in vascular smooth muscle: Role of JNK2 and Crm-1. Journal of Biological Chemistry, 277(40):37756-37764, 2003.
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Amberg, G.C., Bonev, A.D., Rossow, C.F., Nelson, M.T., and Santana, L.F. Modulation of the molecular composition of large conductance, Ca2+ activated K+ channels in vascular smooth muscle during hypertension. Journal of Clinical Investigation, 112:717-724, 2003.
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Wellman, G.C. and Nelson, M.T. Signaling between SR and plasmalemma in smooth muscle: sparks and the activation of Ca2+-sensitive ion channels. Cell Calcium (Review), 34:211-229, 2003.
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Herrera, G.M., Pozo, M.J., Zvara, P., Petkov, G.V., Bond, C.T., Adelman, J.P., and Nelson, M.T. Urinary bladder instability induced by selective suppression of the murine small conductance calcium-activated potassium (SK3) channel. Journal of Physiology, 551:893-903, 2003.
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Taylor, M.S., Bonev, A.D., Gross, T.P., Eckman, D.M., Brayden, J.E., Bond, C.T., Adelman, J.P., and Nelson, M.T. Altered expression of small conductance Ca2+-activated K+ (SK3) channels modulates arterial tone and blood pressure. Circulation Research, 93:124-131, 2003.
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Thorneloe, K.S. and Nelson, M.T. Properties and molecular basis of the mouse urinary bladder voltage-gated K+ current. Journal of Physiology, 549:65–74, 2003.
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Hill-Eubanks, D.C., Gomez, M.F., Stevenson, A.S., and Nelson, M.T. NFAT regulation in smooth muscle. Trends in Cardiovascular Medicine, 13:56-62, 2003.
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Parr, E., Pozo, M.J., Horowitz, B., Nelson MT, and Mawe, G.M. ERG K+ channels modulate the electrical and contractile activities of gallbladder smooth muscle. American Journal of Physiology: Gastrointestinal and Liver Physiology, 284:G392-G398.
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Heppner, T.J., Bonev, A.D., Santana, L.F., and Nelson, M.T. Alkaline pH shifts Ca2+ sparks to Ca2+ waves in smooth muscle cells of pressurized cerebral arteries. American Journal of Physiology: Heart & Circulatory Physiology,. 283:H2169-H2176, 2002.
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Santana, L.F., Chase, E.G., Votaw, V.S., Nelson, M.T, and Greven, R. Functional coupling of calcineurin and protein kinase A in mouse ventricular myocytes. Journal of Physiology, 544:57-69, 2002.
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Herrera, G.M. and Nelson, M.T. Sarcoplasmic reticulum and membrane currents. Novartis Foundation Symposium; 246:189-203, 2002.
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Gomez, M.F., Stevenson, A.S., Bonev, A.D., Hill-Eubanks, D.C., and Nelson, M.T. Opposing actions of IP3 and ryanodine receptors on NFAT regulation in smooth muscle. Journal of Biological Chemistry, 277:37756-37764, 2002.
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Herrera, G.M., Heppner, T.J., and Nelson, M.T. Differential regulation of SK and BK channels by Ca2+ signals from Ca2+ channels and ryanodine receptors in guinea-pig urinary bladder myocytes. Journal of Physiology, 541:483-492, 2002.
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Nelson, M.T. and Herrera, G.M. Molecular physiology: protecting the heart. Nature, 416:273-274, 2002.
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Wellman G.C., Nathan, D.J., Saundry, C.M., Perez, G., Bonev, A.D., Penar, P.L., Tranmer, B.I., and Nelson, M.T. Ca2+ sparks and their function in human cerebral arteries. Stroke, 33:802-808, 2002. Cover figure of journal.
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Welsh, D.G., Morielli, A.D., Nelson, M.T., and Brayden, J.E. Transient receptor potential channels regulate myogenic tone of resistance arteries. Circulation Research, 90:248-250, 2002.
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Pozo, M., Perez, G., Nelson, M.T., & Mawe, G. Ca2+ sparks and BK currents in gallbladder myocytes: Role in CCK-induced response. American Journal of Physiology: Gastrointestinal and Liver Physiology, 282:G165-G174, 2002.
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Petkov, G.V., Bonev, A.D., Heppner, T.J., Brenner, R., Aldrich, R.W., and Nelson, M.T. ß1-subunit of the Ca2+-activated K+ channel regulates contractile activity of mouse urinary bladder smooth muscle. Journal of Physiology, 537:443-452, 2001.
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Wellman, G.C., Cartin, L., Eckman, D.E., Lederer, W.J., and Nelson, M.T. Membrane depolarization, elevated calcium entry and gene expression in cerebral arteries of hypertensive rats. American Journal of Physiology: Heart & Circulatory Physiology, 281: H2559–H2567, 2001.
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Perez, G.J., Bonev, A.D., and Nelson, M.T. Micromolar Ca2+ from sparks activates Ca2+-sensitive K+ channels in rat cerebral artery smooth muscle. American Journal of Physiology: Cell Physiology, 281:C1769–C1775, 2001.
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Schubert, .R and Nelson, M.T. Protein kinases: tuners of the BKCa channel in smooth muscle. Trends in Pharmacological Sciences, 22:505-512, 2001.
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Wellman, G.C., Santana, L.F., Bonev, A.D., and Nelson, M.T. Role of phospholamban in the modulation of arterial Ca2+ sparks and Ca2+-activated K+ channels by cAMP. American Journal of Physiology: Cell Physiology, 281:C1029-C1037, 2001.
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Stevenson, A.S., Gomez, M.F., Hill-Eubanks, D.C., and Nelson, M.T. NFAT4 movement in native smooth muscle: A role for differential Ca2+ signaling. Journal of Biological Chemistry 276:15018-15024, 2001.
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Herrera, G.M., Heppner, T.J., and Nelson, M.T. Voltage dependence of the coupling of Ca(2+) sparks to BK(Ca) channels in urinary bladder smooth muscle. American Journal of Physiology, Cell Physiology 280:C481-C490, 2001.
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Stevenson, A.S., Cartin, L., Wellman, T.L., Dick, M.H., Nelson, M.T., and Lounsbury, K.M. Membrane depolarization mediates phosphorylation and nuclear translocation of CREB in vascular smooth muscle cells. Experimental Cell Research 263:118-130, 2001.
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Brenner, R., Perez, G.J., Bonev, A.D., Eckman, D.M., Kosek, J.C., Wiler, S.W., Patterson, A.J., Nelson, M.T., and Aldrich, R.W. Vasoregulation by the beta1 subunit of the calcium-activated potassium (BK) channel. Nature 407:870-876, 2000. (with a News and Views)
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Jaggar, J.H. and Nelson, M.T. Differential regulation of Ca2+ sparks and Ca2+ waves by UTP in rat cerebral artery smooth muscle cells. American Journal of Physiology, Cell Physiology 279:C1528-1539, 2000.
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Welsh, D.G. and Nelson, M.T. A case for myoendothelial gap junctions (Invited Editorial). Circ.Res.87: 427-428, 2000
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Zaritsky, J.J., Eckman, D.E., Wellman, G.C., Nelson, M.T., and Schwarz, T.L. Targeted disruption of Kir2.1 and Kir2.2 genes reveals the essential role of the inwardly rectifying K+ current in K+-mediated vasodilation. Circulation Research 87:160-166, 2000. (Highlighted by an editorial in the same issue)
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Herrera, G.M., Heppner, T.J., and Nelson, M.T. Regulation of urinary bladder smooth muscle contractions by ryanodine receptors and BK and SK channels. American Journal of Physiology, Regulatory, Integrative and Comparative Physiology 279:R60-R68, 2000.
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Jaggar, J.H., Porter, V.A., Lederer, W.J., and Nelson, M.T. Calcium sparks in smooth muscle. American Journal of Physiology, Cell Physiology 278: C235-C256, 2000. Cover page of journal.
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Gokina, N.I., Knot, H.J., Nelson, M.T., and Osol, G.J. Increased Ca2+ sensitivity as a key mechanism of protein kinase C-induced constriction in pressurized cerebral arteries. American Journal of Physiology, Heart and Circulatory Physiology 277:H1178-H1188, 1999.
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Knot, H.J., Lounsbury, K.M., Brayden, J.E., and Nelson, M.T. Gender differences in coronary artery diameter reflect changes in both endothelial Ca2+ and ecNOS activity. American Journal of Physiology, Heart and Circulatory Physiology 276:H961-H969, 1999.
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Bradley, K.A., Jaggar, J.H., Bonev, A.D., Heppner, T.J., Flynn, E.R.M., Nelson, M.T., and Horowitz, B. Kir2.1 encodes the inwardly rectifying potassium current in rat arterial smooth muscle cells. Journal of Physiology 515:639-651, 1999.
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Perez, G., Bonev, A.D., Patlak, J.B., and Nelson, M.T. Functional coupling of ryanodine receptors to KCa channels in smooth muscle cells from rat cerebral arteries. Journal of General Physiology 113:229-237, 1999.
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Jaggar,J.H., Stevenson, A.S., and Nelson, M.T. Voltage-dependence of Ca2+ sparks in intact cerebral arteries. American Journal of Physiology, Cell Physiology 274:C1755-C1761, 1998.
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Porter, V.A., Bonev, A.D., Knot, H.J., Heppner, T.J., Stevenson, A.S., Kleppisch, T., Lederer, W.J., and Nelson, M.T. Frequency modulation of calcium sparks is involved in dilations of cerebral arteries to cyclic nucleotides. American Journal of Physiology, Cell Physiology 274:C1346-C1355, 1998.
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Knot, H.J., Standen, N.B., and Nelson, M.T. Ryanodine receptors regulate arterial wall [Ca2+] and diameter in cerebral arteries of rat via KCa channels. Journal of Physiology 508:211-221, 1998.
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Knot, H.J. and Nelson, M.T. Regulation of arterial diameter and calcium in cerebral arteries of rat by membrane potential and intravascular pressure. Journal of Physiology 508:199-209, 1998.
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Quayle, J.M., Nelson, M.T., and Standen, N.B. ATP-sensitive and inwardly rectifying potassium channels in smooth muscle. Physiological Reviews 77:1165-1232, 1997.
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Nelson, M.T., Cheng, H.P., Rubart, M., Santana, L.F., Bonev, A., Knot, H., and Lederer, W.J. Relaxation of arterial smooth muscle by calcium sparks. Science 270:633-637, 1995. (with a Perspective from Dr. F. Fay)
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Nelson, M.T. and Quayle, J.M. Physiological roles and properties of potassium channels in arterial smooth muscle. American Journal of Physiology, Cell Physiology 268:C799-C822, 1995.
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Nelson, M.T. and J.E. Brayden. Regulation of arterial tone by calcium-dependent K+ channels and ATP-sensitve K+ channels. Cardiovascular Drugs and Therapy 7:605-607, 1993.
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Brayden, J.E. and Nelson, M.T. Regulation of arterial tone by activation of calcium-dependent potassium channels. Science 256:532-535, 1992.
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Nelson, M.T., Patlak, J.B., Worley, J.F., and Standen, N.B. Calcium channels, potassium channels and the voltage-dependence of arterial smooth muscle tone. American Journal of Physiology, Cell Physiology 259:C3-C18, 1990.
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Nelson, M.T., Huang, Y., Brayden, J.E., Hescheler, J.K., and Standen, N.B. Arterial dilations in response to calcitonin gene-related peptide involve activation of K+ channels. Nature 344:770-773, 1990.
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Standen, N.B., Quayle, J.M., Davies, N.W., Brayden, J.E., Huang, Y., and Nelson, M.T. Hyperpolarizing vasodilators activate ATP-sensitive K+ channels in arterial smooth muscle. Science 245:177-180, 1989.
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Nelson, M.T., Standen, N.B., Brayden, J.E., and Worley, J.F. Noradrenaline contracts arteries by activating voltage-dependent calcium channels. Nature 336:382-385, 1988.
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Zschauer, A., Van Breemen, C., Buhler, F.R., and Nelson, M.T. Calcium channels in thrombin activated human platelet membranes incorporated into planar phospholipid bilayers. Nature 334:703-705, 1988.
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Nelson, M.T., French, R.J., and Krueger, B.K. Voltage-dependent calcium channels from rat brain incorporated into planar lipid bilayers. Nature 308:77-80, 1984.
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Nelson, M.T. and Blaustein, M.P. Effects of ATP and vanadate on calcium efflux from barnacle muscle fibers. Nature 289:314-316, 1981.
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Link to Dr. Nelson's Publications
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