Redox Biology and Pathology Research

EvPath250x180The Redox Biology and Pathology Program has expanded considerably over the past several years in terms of participating faculty, extramural grant funding, graduate and postdoctoral trainees, and use of central core facilities.

The primary focus of the research effort is the effect of environmental agents on cell signaling pathways leading to changes in cell phenotype, subsequent alterations in organ structure and function, and eventually disease.

Faculty research in Redox Biology and Pathology is supported by a wide variety of private and public agencies. Recently faculty in this group attained funding for a National Institutes of Health COBRE (Centers for Biomedical Research Excellence) grant in Translational Research in Lung Biology and Disease.

The research interests in Redox Biology and Pathology can be grouped into three broad areas:

  • Environmental Lung Disease
    • asthma
    • fibrosis
    • cancer
  • Cell Signaling in
    • Proliferation
    • Injury
    • Apoptosis
  • DNA Damage/Genetic Toxicology

Research Focus

  • delineation of the specific molecular and pathological effects of physiologically relevant doses of environmental agents on specific target cells in the lung and other organs.
    • Over time, genetic and epigenetic changes in cell phenotype elicited by environmental agents lead to tissue remodeling, alterations in organ structure and function, and disease.
  • Multi-format approaches
    • Utilizing
      • Cell culture
      • animal model systems
      • human materials
    • are used to test specific hypotheses with the aim of identifying crucial pathways that may represent therapeutic targets in man.
  • Contemporary research
    • methods in
      • molecular biology
      • cell biology
      • organ physiology
    • integrated into research programs that support and are facilitated by Larner College of Medicine core facilities
      • Flow Cytometry
      • DNA analysis
      • Cell Imaging
      • Transgenic Mice
      • Biobank

Integration and Commitment

The Redox Biology and Pathology Program is integrated with many other research endeavors in the Larner College of Medicine, the University of Vermont and  the University of Vermont Medical Center.

  • Co-sponsors a well attended seminar program with the Cell Signaling Program
    • a broad initiative sponsored by joint funding from
      • The University of Vermont Cancer Center
      • the Departments of
        • Pathology and Laboratory Medicine
        • Molecular Physiology and Biophysics
        • Molecular Pharmacology
  • Members of the Redox Biology and Pathology Program also
    • participate in other research programs in The University of Vermont Cancer Center
    • hold joint appointments in other Departments
    • act as thesis advisors for graduate students in
      • Cellular, Molecular and Biomedical Sciences (CMB) program
      • Microbiology and Molecular Genetics
      • Molecular Pharmacology
      • Molecular Physiology and Biophysics
      • Biochemistry
    • Program scientists serve on a wide variety of administrative committees within the Larner College of Medicine and University of Vermont
      • concerning research and graduate education
        • the Graduate Education Committee
        • the CMB steering committee
        • the institutional review boards addressing animal and laboratory protocols

Training Activities

Maintenance of a competitive research program requires a strong commitment to the training of graduate students, medical students, and postdoctoral fellows.

Members of the Redox Biology and Pathology program participate in multiple graduate programs

  • Cellular, Molecular and Biomedical Sciences (CMB) program
  • Microbiology and Molecular Genetics
  • Molecular Pharmacology
  • Molecular Physiology and Biophysics
  • Biochemistry

Members also lecture in basic science courses in the medical school curriculum.

In addition, the faculty of the Redox Biology and Pathology Program are mentors for undergraduates through HELiX, independent research courses and summer fellowships.

In summary, the faculty of the Redox Biology and Pathology strongly support ongoing institutional efforts to improve undergraduate, graduate and medical student education in the biomedical sciences, as well as postdoctoral training in basic and clinical research. Indeed, because of their record in mentoring students and fellows, several of the laboratories within the program are widely recognized throughout the University as fertile training grounds for trainees in the sciences.