Associate Professor of Medicine; Hematology/Oncology Unit
Principal Researcher, Laboratory for Clinical Biochemistry Research |
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Work Address
Fletcher Allen Health Care, Thrombosis and Hemostasis Program, Hematology/Oncology Clinic, 111 Colchester Avenue, Burlington, VT 05401, USA
Phone #: (802) 847-4925
Fax #: (802) 847-1258
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Mary.Cushman@uvm.edu
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Clinical Expertise
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The care of patients with venous thrombosis and its complications, with an emphasis on tailoring treatments to an individual's level of risk, and on evaluations for inherited and acquired hypercoagulable syndromes when appropriate. Evaluation and management of patients with premature or unexplained arterial vascular disease and the role of novel risk factors in their management. Evaluation and management of antiphospholipid syndrome. Optimization of the quality of acute and chronic administration of anticoagulant medications for treatment and prevention of thrombosis.
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Academic Interests
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The epidemiology of coagulation, inflammation, and fibrinolysis phenotypes and genotypes in the population, and their relationships to etiology and pathogenesis of cardiovascular diseases, including myocardial infarction, stroke, and venous thrombosis. The role of disorders of coagulation in venous and arterial thrombotic disease, and the therapy of these disorders. Ethnic group differences in vascular risk factors. Etiologic factors in post-thrombotic syndrome. www.med.uvm.edu/lcbr.
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Education
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1996: M.Sc., Epidemiology, Harvard University, School of Public Health, Boston, Massachusetts
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1989: M.D., University of Vermont College of Medicine, Burlington, Vermont
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1985: B.S. (cum laude), Biology, University of Vermont, Burlington, Vermont
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Postdoctoral Training
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1992-1995: Fellow in Hematology, Department of Medicine, University of Vermont and Fletcher Allen Health Care, Burlington, Vermont
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1993-1995: Research Fellow in Hemostasis, Department of Pathology, University of Vermont, Burlington, Vermont
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1989-1992: Resident in Internal Medicine, Traditional Track, Department of Medicine, Medical Center Hospital of Vermont, Burlington, Vermont
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Certification/Board Eligibility
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American Board of Internal Medicine, Hematology, 1996 & 2006
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American Board of Internal Medicine, 1992
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National Board of Medical Examiners, 1990
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Professional Societies
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Chair, Council on Epidemiology and Prevention, American Heart Association Member
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American College of Physicians, Fellow
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American Society of Hematology, Member
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Council on Arteriosclerosis, Thrombosis, and Vascular Biology, American Heart Association
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International Society on Thrombosis and Haemostasis, Member
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Editorial Boards
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Journal of Thrombosis and Haemostasis, Associate Editor
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Archives of Internal Medicine
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Journal of Thrombosis and Thrombolysis
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Clinical and Translational Science
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Publications
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Recent Peer-Reviewed Publications (from 171 total)
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Cushman M, Folsom AR, Wang L, Aleksic N, Rosamond WD, Tracy RP, Heckbert SH. Fibrin fragment D-dimer and the risk of future venous thrombosis. Blood 2003;101:1243-8.
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Manson JE, Hsia J, Johnson KC, Rossouw JE, Assaf AR, Lasser NL, Trevisan M, Black HR, Heckbert SR, Detrano R, Strickland OL, Wong ND, Crouse JR, Stein E, Cushman M, for the WHI Investigators. Estrogen plus progestin and risk of coronary heart disease: final results from the Women's Health Initiative randomized clinical trial. New Engl J Med.2003;349-523-34
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Ornstein DL, Cushman M, Cardiology Patient Page: Factor V Leiden. Circulation 2003;107:e94-e97.
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Cushman M, Kuller LH, Prentice R, Rodabough RJ, Psaty BM, Stafford RS, Sidney S, Rosendaal FR, for the Women’s Health Initiative Investigators. Estrogen plus progestin and risk of venous thrombosis. JAMA 2004;292:1573-80.
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Ornstein DL, Cushman M. Women’s issues in venous thromboembolism. Current Hematol Rep. 2004;3:382-8.
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Mukumal KJ, Kronmal RA, Cushman M, Tracy RP. Old and New Risk Factors in Older Adults: Cardiovascular Risk Assessment Late in Life. Am J Geriatr Cardiol 2004;13:69-80.
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Zakai NA, Katz R, Hirsch C, Shlipak MG, Chaves P, Newman A, Cushman M. Prospective study of anemia status, hemoglobin and mortality in the elderly: the Cardiovascular Health Study. Arch Intern Med 2005;165:1-7.
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Howard G, Prineas R, Moy C, Cushman M, Kellum M, Temple E, Graham A, Howard V. Racial and geographic differences in awareness, treatment and control of hypertension: the REasons for Geographic And Racial Differences in Stroke (REGARDS) Study. Stroke 2006;37:1171-8.
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Shrivastava S, Ridker PM, Glynn RJ, Goldhaber SZ, Moll S, Bounameaux H, Bauer KA, Kessler CM, Cushman M. Plasma D-dimer, factor VIII coagulant activity, low-intensity warfarin and the risk of recurrent venous thromboembolism. J Thromb Haemost 2006;4:1208-14.
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Lange L, Carlson CS, Hindorff LA, Lange E, Walston J, Durda JP, Cushman M, Bis JC, Zeng D, Lin D, Kuller LH, Nickerson DA, Psaty BM, Tracy RP, Reiner AP. Polymorphisms in the C-reactive protein gene are associated with plasma C-reactive protein levels and cardiovascular events. JAMA 2006;296:2703-11.
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Cushman M, Glynn R, Goldhaber SZ, Moll S, Bauer KA, Deitcher S, Shrivastava S, Ridker PM. Hormonal factors and risk of recurrent venous thrombosis: the Prevention of Recurrent Venous Thromboembolism Trial. J Thromb Haemost 2006;4:2199-2203.
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Steffen LM, Folsom AR, Cushman M, Jacobs DR Jr, Rosamond W. Greater fish, fruit and vegetable intakes are related to lower incidence of venous thromboembolism: the Longitudinal Investigation of Thromboembolism Etiology. Circulation 2007;115:188-95.
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Kronmal RA, McClelland RL, Detrano R, Shea S, Lima JA, Burke G, Bild DE, Cushman M. Risk factors for progression of coronary artery calcification in asymptomatic subjects: results from the Multi-ethnic Study of Atherosclerosis (MESA). Circulation 2007;115:2722-30.
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Zakai N, Jenny NS, Tracy RP, Reiner AP, Psaty BM, Schwartz S, Cushman M. Comparison of multiple inflammatory markers in the prediction of cardiovascular disease in older men and women. J Thromb Haemost 2007;5:1128-35.
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Cao JJ, Arnold AM, Manolio TA, Psaty BM, Hirsch CH, Polak JF, Kuller LH, Cushman M. Association of carotid artery intima-media thickness, plaques and C-reactive protein with future cardiovascular disease and all-cause mortality: the Cardiovascular Health Study. Circulation 2007;116:32-8.
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Kooperberg C, Cushman M, Hsia J, Robinson JG, Aragaki AK, Lynch JK, Baird AE, Johnson KC, Kuller LH, Beresford SA, Rodriguez B. Can biomarkers identify women at increased stroke risk? The Women’s Health Initiative hormone trials. PLoS Clin Trials 2007;15:e28.
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Cushman M, Epidemiology and risk factors for venous thrombosis. Semin Hematol. 2007;44:62-9.
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Zakai NA, Ohira T, White R, Folsom AR, Cushman M. Prospective study of the activated partial thromboplastin time and risk of incident venous thromboembolism: the Longitudinal Investigation of Thromboembolism Etiology. Am J Med 2008;121:231-8
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Voeks JH, McClure LA, Go RC, Prineas RJ, Cushman M, Kissela BM, Roseman JM. Regional differences in diabetes as a possible contributor to the geographic disparity in stroke mortality: The REasons for Geographic And Racial Differences in Stroke Study. Stroke 2008;39:1675-80
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Ankle-Brachial Index Collaboration. Ankle brachial index combined with Framingham risk score to predict cardiovascular events and mortality: a meta-analysis. JAMA 2008;300:197-208.
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Glasser CP, Cushman M, Prineas R, Kleindorfer D, Prince V, You Z, Howard VJ, Howard G. Does differential prophylactic aspirin use contribute to racial and geographic disparities in stroke and coronary heart disease? Prev Med 2008;47:161-6.
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Johnson JV, Lowell J, Badger GJ, Rosing J, Tchaikovski S, Cushman M. Effects of oral and transdermal contraception on vascular risk markers. Obstet Gynecol 2008;111:278-84.
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Ranjit N, Diez-Roux AV, Shea S, Cushman M, Ni H, Seeman T. Socioeconomic position, race/ethnicity and inflammation in the Multi-Ethnic Study of Atherosclerosis. In Press, Circulation.
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Wattanakit K, Cushman M, Stehman-Breen C, Heckbert SR, Folsom AR. Chronic kidney disease and risk of venous thromboembolism: the Longitudinal Investigation of Thromboembolism Etiology (LITE). In Press, J Am Soc Nephrol.
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Cushman M, Cantrell RA, McClure LA, Howard G, Prineas RJ, Moy CS, Temple EM, Howard VJ. Estimated 10-year Stroke Risk by Region and Race in the United States. Annals Neurol 2008;64:507-13.
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Reiner AP, Carty CL, Jenny NS, Nievergelt C, Cushman M, Stearns-Kurosawa DJ, Kurosawa S, Kuller LH, Lange LA. PROC, PROCR and PROS1 polymorphisms, plasma anticoagulant phenotpes, and risk of cardiovascular disease and mortality in older adults: the Cardiovascular Health Study. J Thromb Haemost 2008;6:1625-32.
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Fried LF, Katz R, Cushman M, Sarnak M, Shlipak MG, Kuller L, Newman AB. Change in cardiovascular risk factors with progression of kidney disease. Am J Nephrol 2008;29:334-41.
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McClelland W, Newsome BB, McClure LA, Cushman M, Howard G, Audhya P, Abramson JL, Warnock DG. Chronic kidney disease is often unrecognized among patients with coronary heart disease: the REGARDS cohort study. Am J Nephrol 2009;29:10-17.
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Book Chapters/Reviews
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Cushman M. Novel Risk Factors: C-reactive Protein. In Women and Heart Disease, 2nd Ed. Wenger N, Collins P, eds. Taylor & Francis 2005. pp. 123-132.
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Cushman M. Inherited Risk Factors for Venous Thromboembolism. Hematology 2005. The American Society of Hematology. pp 452-7.
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Cushman M. Hormone Replacement Therapy and Inflammation. In C-reactive Protein and Cardiovascular Disease, Ridker PM, Rifai N, eds. MediEdition 2006. pp 263-276.
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Cushman M, Alving BM. Risk Factors for Arterial Thrombosis. In, Consultative Hemostasis and Thrombosis, 2nd Ed. Kitchens CS, Alving BM, Kessler CM, eds. W.B. Saunders Company 2007.
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