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Pathology		 Pathology

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Lord Kelvin 1824-1907

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Richard Albertini
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Most Recent Publications (2003 - Present)
   
  1. Cummins AB, Palmer C, Mossman BT and Taatjes DJ: Persistent localization of activated extracellular signal-regulated kinases (EKR1/2) is epithelial cell specific in an inhalation model of asbestosis. Am J Pathol 162:713-720, 2003.

  2. Shukla A, Ramos-Nino M, Mossman B: Cell signaling and transcription factor activation by asbestos in lung injury and disease. Int J Biochem Cell Biol 35:1198-209, 2003.

  3. Mossman BT: Introduction to serial reviews on the role of reactive oxygen and nitrogen species (ROS/RNS) in lung injury and diseases. Free Radic. Biol. Med. 34(9):1115-1116, 2003.

  4. Shukla A, Gulumian M, Hei TK, Kamp D, Rahman Q, and Mossman BT: Multiple roles of oxidants in the pathogenesis of asbestos-induced diseases. Free Radic. Biol. Med. 34(9):1117-1129, 2003.

  5. Ramos-Nino ME, Scapoli L, Martinelli M, Land S, and Mossman BT: Microarray analysis and RNA silencing link fra-1 to cd44 and c-met expression in mesothelioma. Cancer Res. 63(13):3539-3545, 2003.

  6. Ramos-Nino ME, Heintz N, Scapoli L, Martinelli M, Land S, Nowak N, Haegens A, Manning B, Manning N, MacPherson M, Stern M and Mossman B: Gene profiling and kinase screening in asbestos-exposed epithelial cells and lungs. Am J Respir Cell Mol Biol 29(3, pt 2):S51-S58, 2003.

  7. Shukla A, Stern M, Lounsbury KM, Flanders T, and Mossman BT: Asbestos-induced apoptosis is protein kinase C delta-dependent. Am. J. Respir. Cell Mol. Biol. 29:198-205, 2003.

  8. Li, M, Mossman BT, Kolpa, E, Timblin CR, Shukla A, Taatjes DJ, and Fukagawa NK: Age-related differences in MAP kinase activity in VSMC in response to glucose or TNF-alpha. J Cell Physiology 197:418-425, 2003.

  9. Shukla A, Jung M, Stern M, Fukagawa NK, Taatjes DJ, Sawyer D, Van Houten B and Mossman BT: Asbestos induces mitochondrial DNA damage and dysfunction linked to the development of apoptosis. Am J Physiol (Lung Cell & Mol Physiol) 285:L1018-L1025, 2003.

  10. Scapoli L, Ramos-Nino ME, Martinelli M, and Mossman BT: Src-dependent ERK5 and Src/EGFR-dependent ERK1/2 activation is required for cell proliferation by asbestos. Oncogene 23(3):805-813, 2004.

  11. Jung M, Grunberg S, Timblin C, Buder-Hoffman S, Vacek P, Taatjes DJ and Mossman BT: Paclitaxel and vinorelbine cause synergistic increases in apoptosis but not in microtubular disruption in human lung adenocarcinoma cells (A-549). Histochem. Cell Biol. 121:115-121, 2004.

  12. Yuan Z, Taatjes DJ, Mossman BT, Heintz NH. The duration of nuclear extracellular signal-regulated kinase 1 and 2 signaling during cell cycle reentry distinguishes proliferation from apoptosis in response to asbestos. Cancer Res. 64(18):6530-6. 2004 Sep 15.

  13. Shukla A, Flanders T, Lounsbury KM, Mossman BT. The gamma-glutamylcysteine synthetase and glutathione regulate asbestos-induced expression of activator protein-1 family members and activity. Cancer Res. 64(21):7780-6. 2004 Nov.

  14. Mossman BT, Klein G, Zur Hausen H. Modern Criteria to determine the etiology of human carcinogens. Semin Cancer Biol. 14(6):449-52. 2004 Dec.

  15. Ramos-Nino, ME, Vianale G, Sabo-Attwood T, Mutti L, Porta C, Heintz N, Mossman BT. Human mesothelioma cells exhibit tumor cell-specific differences in phosphatidylinositol 3-kinase/AKT activity that predict the efficacy of Onconase. Mol Cancer Ther. 4(5): 835-42, 2005 May.

  16. Altomare DA, You H, Xiao GH, Ramos-Nino ME, Skele KL, De Rienzo A, Jhanwar SC, Mossman BT, Kane AB, Testa JR. Human and mouse mesotheliomas exhibit elevated AKT/PKB activity, which can be targeted pharmacologically to inhibit tumor growth. Oncogene. 24(40): 6080-9, 2005 Sep.

  17. Barlow CA, Shukla A, Mossman BT, Lounsbury KM. Oxidant mediated CREB activation: calcium regulation and role in apoptosis of lung epithelial cells. Am J Respir Cell Mol Biol. 34(1):7-14, 2006.

  18. Sabo-Attwood T, Ramos-Nino M, Bond J, Butnor KJ, Heintz N, Gruber AD, Steele C, Taatjes DJ, Vacek P, Mossman BT. Gene expression profiles reveal increased mClca3 (Gob5) expression and mucin production in a murine model of asbestos-induced fibrogenesis. Am J Pathol. 167(5): 1243-56, 2005 Nov.

  19. Shukla A and Mossman BT: Asbestosis and asbestos-related cancers: role of reactive oxygen and nitrogen species (ROS/RNS). In: V Vallyathan, V Castranova and X Shi, eds., Oxygen/Nitrogen Radicals: Lung Injury and Disease. Marcel-Dekker, Inc., New York, NY, 2004.

  20. Ramos-Ninos ME, Martinelli M, Scapoli L, and Mossman BT: Asbestos-induced mesothelioma. In: Pass, Vogelzang and Carbone, eds. Malignant Mesothelioma: Advances in Pathogenesis, Diagnosis, and Translational Therapies. Springer Science + Business Media, Inc., New York, NY, pp. 21-33, 2005.

  21. Manning CB, Taatjes DJ and Mossman BT: Analysis of asbestos-induced gene expression changes in bronchiolar epithelial cells using laser capture microdissection and quantitative reverse-transcriptase polymerase chain reaction (QRT-PCR), In: Taatjes DJ and Mossman BT, eds. Cell Imaging Techniques: Methods and Protocols. In: Methods in Molecular Biology. Humana Press, Inc. 319:231-6, 2006.

  22. Stern M, Taatjes DJ, and Mossman, BT: Multifluorescence labeling techniques and confocal laser scanning microscopy on lung tissue, In: Taatjes DJ and Mossman BT, eds. Cell Imaging Techniques: Methods and Protocols. In: Methods in Molecular Biology. Humana Press, Inc. 319:67-76, 2006.

  23. Shukla A, Vacek P, and Mossman BT: Dose response relationships in expression of biomarkers of cell proliferation in in vitro assays and inhalation experiments. Nonlinearity in Biology, Toxicology and Medicine. 2:117-128, 2004.

  24. Swain W and Mossman BT. Mesothelial carcinogenesis: effects of asbestos and inflammatory cytokines on cell signaling events and gene expression by normal mesothelial cells. In: O'Byrne K and Kindler H, eds. Malignant Pleural Mesothelioma. Oxford University Press, (In Press).

  25. Heintz NH and Mossman BT. Molecular responses to asbestos: Induction of cell proliferation and apoptosis via modulation of redox-dependent signaling pathways. In: Craighead, JE and Gibbs A, eds. Asbestos and its diseases. Oxford University Press, (In Press).

  26. Manning CB, Sabo-Attwood T, Robledo RF, Rincon M, Shukla A, Ramos-Nino M, Vacek P, Henenway D, Taatjes DJ, Mossman BT. Transgenic targeting of ERK mitogen activated protein kinases to lung epithelium inhibits proliferation and normal differentiation after injury (Submitted). 

  27. Haegens A, van der Vliet A, Butnor K, Heintz N, Hemenway D, Vacek P, Freeman BA, Hazen SL, Brennan ML, and Mossman BT. Asbestos-induced lung inflammation and epithelial cell proliferation are altered in myeloperoxidase-null mice. Cancer Res 65(21):9670-7, 2005.

  28. Ramos-Nino ME and Mossman BT. Microarray analysis and RNA silencing to determine genes functionally important in mesothelioma. In: K. Appasani, ed., RNA Interference Technology: From Basic Science to Drug Development. Cambridge University Press, Cambridge, UK, 447-69, 2004.

  29. Sabo-Attwood T, Ramos-Nino M, Mossman BT. Environmental carcinogenesis. In: Oncology: An Evidence Based Approach. Springer-Verlag, NY (In Press).

  30. Swain WA, O'Bryne KJ, Houghton CE, Ramos-Nino M, Mossman BT, Faux SP. Epiderimal growth factor receptor dependent activation of the AKT pathway in human mesothelial cells exposed to asbestos (Submitted).

  31. Li M, Liu RM, Timblin C, Meyer S, Mossman BT, Fukagawa NK: Age affects ERK1/2 and NRF2 signaling in the regulation of GCLC expression J Cell Physiology 206(2):518-25, 2005.

  32. Altomare DA, You H, Xiao GH, Ramos-Nino ME, Skele KL, De Rienzo A, Jhanwar SC, Mossman BT, Kane AB, Testa JR. Human and mouse mesotheliomas exhibit elevated AKT/PKC activity, which can be targeted pharmacologically to inhibit tumor cell growth. Oncogene 24(40):6080-9, 2005.

  33. Shukla A, Mossman  BT. Molecular mechanisms of environmental particulates in lung inflammation and fibrosis. Research Signpost 37/661 (2), Fort P.O., Trivandum-695 023, Kerala, India.

  34. Carbone M, Rdzanek MA, Rudzinski JJ, De Marco MA, Bocchetta M, Ramos Nino M, Mossman B, Pass HI. SV40 detection in human tumor specimens. Cancer Res. 65(21):10120-1, 2005.

  35. Shukla A, Barrett TF, Nakayama KI, Nakayama K,  Mossman BT, Lounsbury K. Transcriptional upregulation of MMPs 12, 13, and TIMP 1 by asbestos occurs via a PKC delta dependent pathway in murine lung. FASEB J. 20(7): 997-9, 2006.

  36. Blumen S, Ramos-Nino M, Pass H, Testa J, Carbone M, Mossman BT. Cellular and molecular parameters of mesothelioma. Journal of Cellular
    Biochemistry (In Press).

  37. Levis J, Mossman BT. Cell signaling pathways elicited by particles. In: Donaldson and Borm, eds.: The Toxicology of Particles. (In Press)

  38. Shukla A, Mossman BT. Oxidants and antioxidants: Oxidants. In: Laurent and Shapiro, eds. Encyclodpedia of Respiratory Medicine. Elsevier Limited, Oxford, UK, 2005. (In Press).

  39. Mossman BT. Assessment of the pathogenic potential of asbestiform vs. nonasbestiform particulates (cleavage fragments) in in vitro (cell or organ culture) models and bioassays. Journal of Respiratory Regulations of Toxicology and Pharmacology. (In Press).

  40. Lee PJ, Zhang X, Shan P, Ma B, Lee CG, Homer RJ, Zhu Z, Rincon M, Mossman BT, Elias J. ERK1/2 mitogen activated protein kinase selectively mediates IL-13 induced lung inflammation and remodeling in vivo. Journal of Clinical Investigation. J Clin Invest. 116(1):163-73, 2006.

  41. Mossman BT. Chemical and environmental agents. In: Cagle P, Zander DS, Jagirdar J, Barrios R, Haque A, and Popper H, eds. Molecular Pathology of Lung Disease. (In Press).

  42. O'Hara KA, Nemec AA, Alam J, Klei LR, Barchowsky A, Mossman BT. Chromium (VII) inhibits heme oxygenase-1 expression in vivo and in arsenic-exposed human airway epithelial cells. (Submitted).

  43. Mossman BT, Lounsbury KM, Reddy SP. Oxidants and signaling by mitogen-activated protein kinases (MAPK) in lung epithelium. Am J Respir Cell Mol Biol, 34(6):666-9, 2006.

  44. Adler KB, Shapiro SD, Gallup M, Wu R, Randell SH, Holtzman MJ, Evans CM, Jacoby DB, Tesfaigzi Y, Rose MC, Mossman BT, Prince A, Reddy SP, Davis CW, Matthay MA. Airway epithelium, inflammation, and mechanisms of disease: A tribute to Carol B. Basbaum. Am J Respir Cell Mol Biol. 34(5):523-6, 2006.

 
Full List of Dr. Mossman's Publications on Pubmed.

   
 
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