E. Ross Colgate, Ph.D., M.P.H.

Faculty Scientist

Training & Education

Dr. E. Ross Colgate received her Ph.D. in 2018 from the University of Vermont Larner College of Medicine, studying Clinical and Translational Science with a focus on infectious disease and global health research. Dr. Colgate also received a Master of Public Health degree in International Health and Development from Tulane University School of Public Health and Tropical Medicine in 2002.

Research Interests

Globally, dehydrating diarrhea remains the second leading cause of death among children age 1 month to 5 years, with a disproportionate burden in South Asia and Sub-Saharan Africa. Recent data suggest children in these setting are often infected with multiple enteric co-pathogens, both at the time of diarrhea and in “normal” stools. We have learned that long-term consequences of enteric infection, including cognitive development delays and stunting, are similar with and without overt diarrhea. 

My research interests focus primarily on ameliorating the burden of enteric pathogen infection among children in low- and middle-income countries. I have shown important associations between zinc deficiency in infants and increased risk of viral and bacterial enteric infection, forming the basis for translational investigation of the role of zinc at the host-pathogen interface and consideration of zinc supplementation as a public health measure to prevent enteric infection. I am also interested in incorporating metagenomic and microbiome analyses into complex systems models to better characterize the multi-dimensional interactions between young hosts and enteric pathogens as a means to identify potential targets for effective interventions to prevent poor health outcomes in children.

Teaching

CTS 310: Conducting Clinical and Translational Research - Instructor

Featured Publications

Colgate, E. R., R. Haque, D. M. Dickson, M. P. Carmolli, J. C. Mychaleckyj, U. Nayak, F. Qadri, M. Alam, M. C. Walsh, S. A. Diehl, K. Zaman, W. A. Petri, Jr., and B. D. Kirkpatrick.  2016.  "Delayed Dosing of Oral Rotavirus Vaccine Demonstrates Decreased Risk of Rotavirus Gastroenteritis Associated With Serum Zinc: A Randomized Controlled Trial."  Clin Infect Dis 63:634-41. PMCID: 27217217

Mychaleckyj, J. C., R. Haque, M. Carmolli, D. Zhang, E. R. Colgate, U. Nayak, M. Taniuchi, D. Dickson, W. C. Weldon, M. S. Oberste, K. Zaman, E. R. Houpt, M. Alam, B. D. Kirkpatrick, and W. A. Petri, Jr.  2016.  "Effect of Substituting IPV for tOPV on Immunity to Poliovirus in Bangladeshi Infants: An Open-Label Randomized Controlled Trial."  Vaccine 34: 358-66. PMCID: 26643930

Rogawski, E. T., J. A. Platts-Mills, E. R. Colgate, R. Haque, K. Zaman, W. A. Petri, and B. D. Kirkpatrick.  2018.  "Quantifying the Impact of Natural Immunity on Rotavirus Vaccine Efficacy Estimates: A Clinical Trial in Dhaka, Bangladesh (Provide) and a Simulation Study."  J Infect Dis 217: 861-68.

Lee, B., M. Carmolli, D. M. Dickson, E. R. Colgate, S. A. Diehl, M. I. Uddin, S. Islam, M. Hossain, T. A. Rafique, T. R. Bhuiyan, M. Alam, U. Nayak, J. C. Mychaleckyj, M. M. McNeal, W. A. Petri, Jr., F. Qadri, R. Haque, and B. D. Kirkpatrick.  2018.  "Rotavirus-Specific Iga Responses Are Impaired and Serve as a Sub-Optimal Correlate of Protection among Infants in Bangladesh."  Clin Infect Dis.

Donowitz, J. R., H. Cook, M. Alam, F. Tofail, M. Kabir, E. R. Colgate, M. P. Carmolli, B. D. Kirkpatrick, C. A. Nelson, J. Z. Ma, R. Haque, and W. A. Petri, Jr.  2018.  "Role of Maternal Health and Infant Inflammation in Nutritional and Neurodevelopmental Outcomes of Two-Year-Old Bangladeshi Children."  PLoS Negl Trop Dis 12: e0006363
Ross Colgate, PhD holding baby in Dhaka

Contact Information

Office: Given C219B

Phone: 802-656-7743

Email