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The practice of medicine is an art, not a trade, a calling, not a business, a calling in which your heart will be exercised equally with your
head.
-Sir William Osler
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Chris E. Holmes, MD, PhD
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Assistant Professor |
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Work address: 208 South Park Drive, Colchester, VT 05446
Clinic Address: ACC West Pavilion, 2nd Floor, Hematology and Oncology Clinic, FAHC
Phone: (802) 847-8400
Email: ceholmes@uvm.edu |
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Research Interests
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Dr. Holmes’s research laboratory focuses on the role of platelets in tumor angiogenesis and metastasis and the inhibition of cancer progression using platelet antagonist therapy. Studies conducted in our laboratory suggest protein release from platelets can be selectively regulated to influence cancer progression. Current studies focus on the influence of key platelet activation pathways and selective activation antagonists on angiogenic protein release from platelets and the processes of angiogenesis and metastasis using cellular models. Clinical studies currently accruing are directed at 1) determining the influence of tamoxifen and aromatase inhibitors on platelet activated angiogenic protein release in women with breast cancer and 2) determining the influence of the anti-platelet drug, aspirin, on platelet mediated angiogenic and metastatic protein release in women with breast cancer.
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In addition to platelet based laboratory and clinical studies, Dr. Holmes also has an active clinical and research interest in thrombosis and hemostasis and is the PI for a recently opened single center, randomized, blinded study designed to determine the impact of lymphedema therapy on post-thrombotic syndrome.
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Clinical Expertise
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Disorders of Platelet Number and Function
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Hemostasis and Thrombosis
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Benign and Malignant Hematology
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Education
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1997: M.D., University of Virginia School of Medicine
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1993: Ph.D., University of Virginia Graduate School of Arts and Sciences, Department of Chemistry
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1988: B.S., James Madison University, Department of Chemistry, Magna Cum Laude, Honors Scholar
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Postdoctoral Training
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2001-2004: Fellow, Hematology & Oncology, University of Vermont and Fletcher Allen Health Care
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2002: Postdoctoral Research Fellow, National Institutes of Health, University of Vermont, Hemostasis and Thrombosis Program for Academic Trainees
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2000-2001: Chief Resident, Department of Internal Medicine, University of Vermont
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1998-2000: Resident, Internal Medicine, University of Vermont-Fletcher Allen Health Care
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1997-1998: Intern, Internal Medicine, University of Vermont-Fletcher Allen Health Care
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Certification/Board Eligibility
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2000 Certified, Internal Medicine, American Board of Internal Medicine
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2004 Certified, Hematology, American Board of Internal Medicine
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2004 Certified, Medical Oncology, American Board of Internal Medicine
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Academic Appointments
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2004 Assistant Professor of Medicine, University of Vermont School of Medicine
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2004 Member, Graduate Faculty, University of Vermont
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Clinical Appointments
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2004 Attending Physician, Fletcher Allen Health Care, Burlington, VT
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Professional Societies
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2001 American Society of Hematology
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2001 American Society of Clinical Oncology
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2002 Cancer and Leukemia Group B
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1997 American College of Physicians
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Publications
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Selected Publications
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Holmes CE, Levis J, Ornstein DL. Activated platelets enhance ovarian cancer cell invasion in a cellular model of metastasis, Clin Exp Metastasis 2009, epub, 10.1007/s10585-009-9264-9.
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Holmes, C.E., Huang, J.C., Cartelli, C., Rimmer, J. & Cushman, M.C. “The Frequency of Thrombocytopenia and Clinical Evaluation of Heparin-Induced Thrombocytopenia in Patients Receiving Continuous Renal Replacement Therapy”, 2007, manuscript under review by co-authors.
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Van der Bom JG, Heckbert SR, Kronmal RA, Lumley T, Holmes CE, Cushman M, Folsom AR, Rosendaal FR, Psaty BM. Platelet Count and the Risk for Thrombosis in the Elderly. J Thromb Haemost 2009; 7: 399-405.
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Madsen, N.J., Holmes, C.E., Serrano, F.A., Sobel, B.E. & Schneider, D.J. “Influence of Preparative Procedures on Assay of Platelet Function and Apparent Effects of Antiplatelet Agents”, 2007, submitted.
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Search for more publications on PubMed
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