The Gerontology Unit is presently focused on Clinical or Basic Science Research generally related to broad interests in nutrition and oxidant/antioxidant balance.  Specific projects focus on the following areas:

- Effect of age and glycemia on transcription factors using vascular smooth muscle cells and lung fibroblasts.

- Effect of age and diabetes mellitus on glutathione synthesis.

- Effect of age on the response of lung fibroblasts to particulate matter or inflammatory cytokines.

- Methionine and homocysteine metabolism in humans.

- Application of the Problem Knowledge Couplers (PKC) approach to follow-up and management of the elderly.

Studies in human volunteers use stable isotope tracer methodology, indirect calorimetry, and skeletal muscle biopsies to explore whole body energy and amino acid metabolism and, specifically, the relationship between aging and diabetes mellitus and their effects on oxidative stress. In addition, tracer studies are conducted to explore the interrelationships between sulfur amino acid (methionine and cysteine) metabolism and glutathione, the tripeptide which, together with ascorbic acid, forms the body's major antioxidant defense system. Work has also focused on examining mitochondrial DNA deletions and/or mutations as related to the age-associated glucose intolerance, lower energy expenditure, and decreased muscle mass, so important in human aging. Collaborative studies are conducted in conjunction with Dr. David Maughan in the Department of Molecular Physiology and Biophysics in the College of Medicine to examine cardiac muscle mechanics and its relationship to indices of oxidative injury. Plans to develop collaborative research programs in the primary care of the elderly, community-based education regarding the needs of the elderly and the outcomes of medical and social interventions on the health of the elderly are underway.