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The practice of medicine is an art, not a trade, a calling, not a business, a calling in which your heart will be exercised equally with your head.
-Sir William Osler
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Mina Peshavaria, Ph.D.
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Research Assistant Professor |
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Work Address
Medicine-Endocrinology, UVM Colchester Research Facility Rm 110D, VT 05446, Colchester 05446, USA
Phone #: (802) 656-8301
Fax #: (802) 656-8031
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mina.peshavaria@uvm.edu
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Research Interests
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Pancreatic regeneration using animal models
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Cross talk between signaling pathways and islet transcription factors during beta cell adaptation in insulin resistant states
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Education
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Ph.D. (Biochemistry/Molecular Biology) 1991, University of Southampton.
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B.Sc. (Biochemistry) 1979, University of Kent at Canterbury, UK.
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Postdoctoral Training
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1992 - 97 Post Doctoral Associate (Molecular Physiology/Biophysics), Vanderbilt School of Medicine.
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Professional Societies
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American Diabetes Association
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Publications
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Selected Pertinent Publications:
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Moibi JA, Gupta D, Jetton TL, Peshavaria M, Desai R, Leahy JL (2007) Peroxisome Proliferator-Activated Receptor-{gamma} Regulates Expression of PDX-1 and NKX6.1 in INS-1 Cells. Diabetes 56: 88-95.
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Peshavaria M, Larmie BL, Lausier J, Satish B, Habibovic A, Roskens V, LaRock K, Everill B, Leahy JL, and Jetton TL. (2006) Regulation of pancreatic ß-cell regeneration in the normoglycemic 60 % partial pancreatectomy mouse. Diabetes 55:.3289-98.
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Perera HM, Caldwell ME, Hayes-Patterson D, Teng L, Peshavaria M, Jetton TL, Labosky PA (2006). Expression and shifting subcellular localization of the transcription factor, Foxd3, in embryonic and adult pancreas. Gene Expr Patterns 6:971-7. Epub Apr 22.
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Jetton TL, Lausier J, LaRock K, Trotman WE, Larmie B, Habibovic A, Peshavaria M, Leahy JL. Mechanisms of compensatory beta-cell growth in insulin-resistant rats: roles of Akt kinase.Diabetes. 2005 54(8): 2294-304.
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Peshavaria M, Cissell MA, Henderson E, Petersen HV, Stein R. The PDX-1 activation domain provides specific functions necessary for transcriptional stimulation in pancreatic beta-cells. Mol Endocrinol. 2000 14: 1907-17.
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Wu KL, Gannon M, Peshavaria M, Offield MF, Henderson E, Ray M, Marks A, Gamer LW, Wright CV Stein R. Hepatocyte nuclear factor 3beta is involved in pancreatic beta-cell-specific transcription of the pdx-1 gene. Mol Cell Biol. 1997 17: 6002-13
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Peshavaria M, Henderson E, Sharma A, Wright CV, Stein R. Functional characterization of the transactivation properties of the PDX-1 homeodomain protein. Mol Cell Biol. 1997 17: 3987-96.
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Olson LK, Sharma A, Peshavaria M, Wright CV, Towle HC, Rodertson RP, Stein R. Reduction of insulin gene transcription in HIT-T15 beta cells chronically exposed to a supraphysiologic glucose concentration is associated with loss of STF-1 transcription factor expression. Proc Natl Acad Sci U S A. 1995 92: 9127-31.
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Peshavaria M, Gamer L, Henderson E, Teitelman G, Wright CV, Stein R. XIHbox 8, an endoderm-specific Xenopus homeodomain protein, is closely related to a mammalian insulin gene transcription factor. Mol Endocrinol. 1994 8: 806-16.
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