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Jay Silveira, Ph.D.
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Work Address
Biochemistry, Given C413
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Jay.Silveira@uvm.edu
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Summary
Background:
Dr. Silveira received his Ph.D. in 2001 from the Department of Biochemistry at the University of Vermont. His graduate work with Dr. Paula Tracy involved assessing the effects of post-translational modifications on the function of factor V, a critical component of the coagulation cascade. After completing his graduate work, Dr. Silveira obtained a postdoctoral fellowship and worked with Dr. Byron Caughey’s prion research group at the National Institutes of Health’s Rocky Mountain Laboratory facility in Hamilton, Montana. Dr. Silveira’s research on prions established a relationship between prion infectivity and the size of prion protein aggregates, revealing that smaller aggregates are inherently more infectious than larger ones. In 2006, Dr. Silveira returned to Vermont and joined the faculty of the Biochemistry department where he serves as a lecturer and a member of Dr. Paula Tracy’s research group.
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Research Overview
Research Interests:
Coagulation Biology & Disease
Enzymology
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Publications
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DeMarco, M.L., Silveira, J.R., Caughey, B., Daggett, V. Structural properties of prion protein protofibrils and fibrils: An experimental assessment of atomic models. Biochemistry 45:15573-15582, 2006.
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Silveira J.R., Raymond G.J., Hughson A.G., Race R.E., Sim V.L., Hayes S.F., Caughey B. The most infectious prion protein particles. Nature 437:257-261, 2005.
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Gould W.R., Simioni P., Silveira J.R., Tormene D., Kalafatis M., Tracy P.B. Megakaryocytes endocytose and subsequently modify human factor V in vivo to form the entire pool of a unique platelet-derived cofactor. Journal of Thrombosis and Haemostasis 3(3):450-456, 2005.
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Silveira, J.R., Gould, W.R., Tracy, P.B. Unique in vivo modifications of coagulation factor V produce a physically and functionally distinct platelet-derived cofactor: Characterization of purified platelet-derived factor V/Va. Journal of Biological Chemistry 279(4):2383-2393, 2003.
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Silveira, J.R., Kalafatis, M., Tracy, P.B. Carbohydrate moieties on the procofactor factor V, but not the derived cofactor factor Va, regulate its inactivation by activated protein C. Biochemistry 41(5):1672-1680, 2002.
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All Silveira Publications
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